In France, cognitive science (e.g., eye-tracking) and neuroscience (e.
View Article and Find Full Text PDFOur aim was to investigate the extent of white matter tissue damage in patients with early Alzheimer disease (AD) using diffusion tensor magnetic resonance imaging (DTI). Although AD pathology mainly affects cortical grey matter, previous magnetic resonance imaging (MRI) studies showed that changes also exist in the white matter (WM). However, the nature of AD-associated WM damage is still unclear.
View Article and Find Full Text PDFPrevious research suggests that the neuropsychological deficits in Alzheimer's disease (AD) are different from that of vascular dementia (VaD), especially with respect to memory, language and executive functions, but negative findings were reported. Our objective was to clarify the cognitive syndrome in AD and VaD in the early stage of these disorders. We investigated 45 patients with early AD, 23 patients with subcortical VaD and 35 normal controls.
View Article and Find Full Text PDFMany current accounts of the origin of intrusions and other confabulatory-like phenomena emphasize the role of a retrieval or postretrieval deficit in these disorders. In the experiments reported herein we examine whether the presence of an interfering task at encoding elicits more intrusions in normal subjects than the presence of an interfering task at retrieval. In Experiment 1, performance in story recall without interference was compared to the performance with an interfering task at retrieval.
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