Publications by authors named "Dorothea Polydorou"
Cutaneous melanoma metastases: Clinical and dermoscopic findings.
J Eur Acad Dermatol Venereol
May 2023
Article Synopsis
- The study focused on the clinical and dermoscopic characteristics of cutaneous melanoma metastases (CMM) in 42 melanoma patients, noting that accurate diagnosis remains difficult due to variability in these features.
- Results showed that both male and female patients exhibited different dermoscopic patterns of CMM, with the homogenous and amelanotic types being the most prevalent, and specific patterns associated with the depth of the primary melanoma.
- The findings suggest that deeper melanomas are more likely to show vascular structures in their metastases, and in some cases, CMM may be the first sign of underlying melanoma.
Article Synopsis
- - Recent studies suggest a potential link between low serum 25-hydroxyvitamin D levels and a higher incidence of cutaneous malignant melanoma (CMM), indicating worse outcomes for patients with such deficiencies.
- - The research analyzed 99 melanoma patients and 97 healthy controls, measuring their serum vitamin D levels and comparing various risk factors and characteristics related to CMM.
- - Although melanoma patients had lower vitamin D levels than healthy controls, the difference did not achieve statistical significance, and no significant associations with cancer severity or characteristics were found.
Article Synopsis
- About 5-10% of melanoma cases are hereditary, with CDKN2A and CDK4 being key genes linked to familial melanoma.
- This study focused on analyzing these gene variants in Greek families with a history of melanoma, involving 52 families in total.
- Findings showed that 46.2% of families had CDKN2A variants, which correlated with a younger age at melanoma diagnosis, but no significant links were found between CDKN2A mutations and MC1R gene variations.
An unusual early onset of lentigo maligna in the fourth decade of life.
Indian J Dermatol Venereol Leprol
April 2019
Article Synopsis
- * Fifteen SNPs were found significantly associated with melanoma risk, with a weighted genetic risk score (GRSGWS) showing an odds ratio of 1.36 for every standard deviation increase, indicating higher risk for individuals in the top 20%.
- * Incorporating the GRSGWS with existing phenotypic risk factors slightly improved melanoma risk prediction, raising the C-statistic from 0.764 to 0.775.
Objectives: Limited data exist about the risk factors of melanoma in the Greek population. We investigated the association of melanoma with phenotypic and solar indices in this darker skin population residing in an environment of high ambient ultraviolet radiation.
Methods: Our study included 200 sporadic melanoma cases and 200 age-, sex-matched control subjects.
Background: Several investigators have described a seasonal variation in the diagnosis of cutaneous melanoma. Limited data exist on the seasonality of melanoma diagnosis in Southern European countries.
Patients And Methods: The seasonal pattern of diagnosis was analyzed in 404 Greek patients diagnosed with cutaneous melanoma (CM) between 1996 and 2004.
Individuals with melanocortin 1 receptor (MC1R) gene variants have been shown to carry an increased risk for the development of melanoma. In this study, we investigated the relationship of MC1R gene variants and the risk of melanoma in 123 melanoma patients and 155 control subjects from Greece. The entire MC1R gene was sequenced for polymorphisms and the results were correlated with host factors and pigmentary characteristics.
View Article and Find Full Text PDFObjective: To evaluate various immunologic markers in the peripheral blood of patients with early and advanced classic Kaposi's sarcoma (CKS).
Design: Cross-sectional study.
Setting: A major referral center for skin and venereal diseases.