Publications by authors named "Dorothea Plundrich"
Article Synopsis
- The study investigates how partial hepatectomy (pHx), a common surgical procedure for colorectal liver metastasis in Stage IV colorectal cancer (CRC), influences tumor progression at a molecular level using a mouse model.
- Mice that underwent pHx showed significant liver growth and a higher metastatic load compared to control mice, indicating that pHx may enhance the spread of CRC to the liver rather than simply removing existing tumors.
- The findings suggest that pHx triggers inflammatory responses and tissue changes in the liver, creating an environment that promotes the establishment of new metastatic tumors, highlighting the need for a better understanding of post-surgery cancer dynamics.
More than half of all patients with colorectal cancer (CRC) develop distant metastasis and, depending on the local stage of the primary tumor, up to 48% of patients present peritoneal carcinomatosis (PC). PC is often considered as a widespread metastatic disease, which is almost resistant to current systemic therapies like chemotherapeutic and immunotherapeutic regimens. Here we could show that tumor cells of PC besides being senescent also exhibit stem cell features.
View Article and Find Full Text PDFColorectal cancer remains one of the most important health challenges in our society. The development of cancer immunotherapies has fostered the need to better understand the anti-tumor immune mechanisms at play in the tumor microenvironment and the strategies by which the tumor escapes them. In this review, we provide an overview of the molecular interactions that regulate tumor inflammation.
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