[Changes in Pulmonary Hemodynamics Resulted From Long-Term Mechanical Heart Support].

Aim      To study the dynamics of right ventricular function and pulmonary hemodynamics in patients with pulmonary hypertension during mechanical circulatory support of the heart.Material and methods  A retrospective analysis was performed for 25 implantations of left ventricular assist device performed in the Meshalkin National Medical Research Center from 2006 through 2021. Mechanical assist devices were implanted in 21 men and 4 women (median age, 37.

NTnC-like genetically encoded calcium indicator with a positive and enhanced response and fast kinetics.

The NTnC genetically encoded calcium indicator has an advantageous design because of its smaller size, GFP-like N- and C-terminal ends and two-fold reduced number of calcium binding sites compared with widely used indicators from the GCaMP family. However, NTnC has an inverted and modest calcium response and a low temporal resolution. By replacing the mNeonGreen fluorescent part in NTnC with EYFP, we engineered an NTnC-like indicator, referred to as YTnC, that had a positive and substantially improved calcium response and faster kinetics.

[Lung Ventilation Efficiency and Quality of Life After Orthotopic Heart Transplantation].

Unlabelled: Aim of the study was assessment of efficiency of lung ventilation and its relationship with quality of life in patients undergoing orthotopic heart transplantation (OHT).

Materials And Methods: The study involved 40 patients with terminal chronic heart failure (CHF) included in the waiting list for heart transplantation. Before surgery and after OHT all patients underwent cardiopulmonary exercise testing, evaluation of clinical status and quality of life (QL) according to the 36-Item Short Form Survey (SF-36).

Genetically encoded calcium indicator with NTnC-like design and enhanced fluorescence contrast and kinetics.

Background: The recently developed genetically encoded calcium indicator (GECI), called NTnC, has a novel design with reduced size due to utilization of the troponin C (TnC) as a Ca-binding moiety inserted into the mNeonGreen fluorescent protein. NTnC binds two times less Ca ions while maintaining a higher fluorescence brightness at the basal level of Ca in neurons as compared with the calmodulin-based GECIs, such as GCaMPs. In spite of NTnC's high brightness, pH-stability, and high sensitivity to single action potentials, it has a limited fluorescence contrast (F/F) and slow Ca dissociation kinetics.

A new design for a green calcium indicator with a smaller size and a reduced number of calcium-binding sites.

Genetically encoded calcium indicators (GECIs) are mainly represented by two- or one-fluorophore-based sensors. One type of two-fluorophore-based sensor, carrying Opsanus troponin C (TnC) as the Ca-binding moiety, has two binding sites for calcium ions, providing a linear response to calcium ions. One-fluorophore-based sensors have four Ca-binding sites but are better suited for in vivo experiments.

Left ventricular assist device implantation combined with surgical ventricular reconstruction.

Nine months after sustaining a transmural anteroseptal myocardial infarction, a 45-year-old man presented with ischemic heart disease, severe mitral valve insufficiency, New York Heart Association functional class IV congestive heart failure, and a left ventricular aneurysm. Coronary angiography revealed 3-vessel disease. Echocardiography showed severe left ventricular impairment, pronounced thrombosis in the left ventricular apex, and low myocardial reserve.

[First-stage surgical correction of dissecting aortic aneurysm according to the Borst's technique using of a new-type stent graft].

Exemplified by clinical experience, shown herein is feasibility of practical application of the Borst's technique for endovascular aortic aneurysm repair using a new-type multiple-branch stent graft provided with a cuff. This method considerably facilitates the establishment of a distal anastomosis of the graft with the aorta.

[A case of surgical treatment of post-traumatic false arteriovenous aneurysm of the right kidney vessels].

This paper describes an experience gained with successful surgical correction of post-traumatic false aneurysm of the right kidney vessels in a 36-year-old patient operated on previously for knife wound and intrahepatic abscess. All-round examination (duplex scanning of the renal arteries, multispiral computed tomography, abdominal aortography, and ultrasonography of the kidneys) revealed a false aneurysm of the medium segment of the right kidney artery measuring 31x21x33 mm. The aneurysm was located downwards, to the rear and inwards from the artery, with marginal posteroinferior calcification drained to the venous collector (the right kidney vein) expanded to 36-40 mm.

[Psychotherapy impact on effectiveness of in-hospital physical rehabilitation in patients with acute coronary syndrome].

Of 103 patients with acute coronary syndrome (mean age 51.6 +/- 0.9 years) 47 patients participated in 5 group psychotherapeutic sessions added to conversional rehabilitation program.

[Pilot experience with skeletal muscles electrostimulation in rehabilitation of patients with complicated myocardial infarction].

Aim: To test electric stimulation of the skeletal muscles in rehabilitation of patients with complicated myocardial infarction.

Materials And Methods: 27 patients with macrofocal myocardial infarction (age 67 +/- 2.4 years) with persisting left ventricular insufficiency in the beginning of the subacute period.