Publications by authors named "Doro Vogt"
Article Synopsis
- Chromosomes play a crucial role in carrying genetic material, and kinetochores help ensure their accurate transfer during cell division by connecting them to the mitotic spindle.
- Kinetochores are complex structures made up of various protein subunits, with the inner kinetochore formed by a group of centromeric proteins (CCAN), and the outer kinetochore created by the KMN network, which binds microtubules.
- The study reveals how a specific CCAN subcomplex (CHIKMLN) increases the binding selectivity for CENP-A nucleosomes, forming a strong link between CENP-A and microtubules, and sheds light on the organization and function of kinetocho
The spindle assembly checkpoint (SAC) monitors microtubule attachment to kinetochores to ensure accurate sister chromatid segregation during mitosis. The SAC members Bub1 and BubR1 are paralogs that underwent significant functional specializations during evolution. We report an in-depth characterization of the kinase domains of Bub1 and BubR1.
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