This paper explores the genotype-phenotype relationship. It outlines conditions under which the dependence of a quantitative trait on the genome might be predictable, based on measurement of a limited subset of genotypes. It uses the theory of real-valued Boolean functions in a systematic way to translate trait data into the Fourier domain.
View Article and Find Full Text PDFThe purpose of this study was to report our institutional experience with patients with COVID-19 who developed acute limb ischemia during hospitalization and to determine the characteristics and clinical outcomes. Between March 2020 and January 2021, we treated 3 patients who were COVID-19-positive and developed acute limb ischemia after they received thromboprophylaxis. We performed an embolectomy by exposing the popliteal artery below the knee to treat an occlusion of the popliteal and tibial arteries.
View Article and Find Full Text PDFThe nerve fiber layer of the human retina is made up of the retinal segments of ganglion cell axons. Its geometry can be described mathematically as a fibration of a 2D domain: a partition of a certain region into smooth curves. Here, we present a simple family of curves that closely models the observed geometry of the nerve fiber layer.
View Article and Find Full Text PDFA 1.5-year-old girl presented with a peripheral iris mass. When the girl was 3 years old, the lesion was excised after it had manifested significant growth.
View Article and Find Full Text PDFCup-disc ratios in the fellow eyes of 26 patients with unilateral, nonarteritic, anterior ischemic optic neuropathy were compared with the ratios in fellow eyes of 29 patients with unilateral idiopathic or demyelinative optic neuritis. The ratios in both groups were also compared with the ratios of a large group of normal subjects evaluated in a population survey. Observers measured the cup-disc ratio by viewing color stereophotographs.
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