On the functional independence of numerical acuity and visual working memory.

Deciding where to direct our vehicle in a crowded parking area or where to line up at an airport gateway relies on our ability to appraise the numerosity of multitudes at a glimpse and react accordingly. Approximating numerosities without actually counting is an ontogenetically and phylogenetically primordial ability, given its presence in human infants shortly after birth, and in primate and non-primate animal species. Prior research in the field suggested that numerosity approximation is a ballistic automatism that has little to do with human cognition as commonly intended.

Combination of mutations in genes controlling DNA repair and high mutational load plays a prognostic role in pancreatic ductal adenocarcinoma (PDAC): a retrospective real-life study in Sardinian population.

Background: Patients with pancreatic ductal adenocarcinoma (PDCA) carrying impaired mismatch repair mechanisms seem to have an outcome advantage under treatment with conventional chemotherapy, whereas the role for the tumor mutation burden on prognosis is controversial. In this study, we evaluated the prognostic role of the mutated genes involved in genome damage repair in a real-life series of PDAC patients in a hospital-based manner from the main Institution deputed to surgically treat such a disease in North Sardinia.

Methods: A cohort of fifty-five consecutive PDAC patients with potentially resectable/border line resectable PDAC (stage IIB-III) or oligometastatic disease (stage IV) and tumor tissue availability underwent next-generation sequencing (NGS)-based analysis using a panel containing driver oncogenes and tumor suppressor genes as well as genes controlling DNA repair mechanisms.

Health-related Quality of Life Profile of Newly Diagnosed Patients With Myelodysplastic Syndromes by Age, Sex, and Risk Group: A Real-world Study by the GIMEMA.

Health-related quality of life (HRQoL) is an important goal of therapy for patients with myelodysplastic syndromes (MDS); however, little is known about HRQoL of these patients at clinical presentation. We report HRQoL profile of newly diagnosed patients with MDS across both the the International Prognostic Scoring System (IPSS) and IPSS-Revised (IPSS-R) classifications, stratified by sex and age group categories, aiming to also establish European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Core30 (EORTC QLQ-C30) reference values for these patients. Analysis was based on 927 patients with a median age of 73.

Has COVID-19 lowered physical activity practice while boosting online searches for professional exercise information?

COVID-19 is an infectious and contagious disease, caused by the SARS-CoV-2 virus. Due to the rapid spreading of the virus and its lethal consequences, the WHO declared a pandemic. One of the main strategies to treat and prevent the spreading was the stay home safe, a social isolation situation that was accompanied by the closing of fitness gyms, city parks and facilities proper to exercise.

Current Trends in Mucosal Melanomas: An Overview.

Primary mucosal melanomas (MMs) are uncommon tumors originating from melanocytes located in the mucous membranes at various anatomic sites within the body. MM significantly differs from cutaneous melanoma (CM) regarding epidemiology, genetic profile, clinical presentation, and response to therapies. Despite these differences, that have important implications for both disease diagnosis and prognosis, MMs are usually treated in the same way as CM but exhibit a lower response rate to immunotherapy leading to a poorer survival rate.

Search for Gamma-Ray Spectral Lines from Dark Matter Annihilation up to 100 TeV toward the Galactic Center with MAGIC.

Linelike features in TeV γ rays constitute a "smoking gun" for TeV-scale particle dark matter and new physics. Probing the Galactic Center region with ground-based Cherenkov telescopes enables the search for TeV spectral features in immediate association with a dense dark matter reservoir at a sensitivity out of reach for satellite γ-ray detectors, and direct detection and collider experiments. We report on 223 hours of observations of the Galactic Center region with the MAGIC stereoscopic telescope system reaching γ-ray energies up to 100 TeV.

On target selection as reflected by posterior ERP components in feature-guided visual search.

The N2pc event-related potential is a widely studied ERP component that reflects the covert deployment of visuo-spatial attention to target stimuli displayed laterally relative to fixation. Recently, an analogous ERP component, named N2pcb, has been proposed as a marker of the deployment of visuo-spatial attention to targets displayed on the vertical midline. Two studies that investigated the N2pcb component found analogous results, using however two different algorithms to compute the amplitude of N2pcb.

Shared Attention Amplifies the Neural Processing of Emotional Faces.

Sharing an experience, without communicating, affects people's subjective perception of the experience, often by intensifying it. We investigated the neural mechanisms underlying shared attention by implementing an EEG study where participants attended to and rated the intensity of emotional faces, simultaneously or independently. Participants performed the task in three experimental conditions: (a) alone; (b) simultaneously next to each other in pairs, without receiving feedback of the other's responses (shared without feedback); and (c) simultaneously while receiving the feedback (shared with feedback).

A neural network predicting the amplitude of the N2pc in individual EEG datasets.

The N2pc is a small amplitude transient interhemispheric voltage asymmetry used in cognitive neuroscience to investigate subject's allocation of selective visuo-spatial attention. N2pc is typically estimated by averaging the sweeps of the electroencephalographic (EEG) signal but, in absence of explicit normative indications, the number of sweeps is often based on arbitrariness or personal experience. With the final aim of reducing duration and cost of experimental protocols, here we developed a new approach to reliably predict N2pc amplitude from a minimal EEG dataset.

Physical activity and medication in Brazilians suffering with non-communicable diseases in quarantine by COVID-19.

This study aimed to compare the practice of physical activity in groups of people with chronic diseases with and without medication, before and during the pandemic. 298 Brazilian individuals with chronic non-communicable diseases such as cardiovascular, metabolic / endocrine, respiratory, orthopedic, gastrointestinal diseases, anxiety and depression were separated into two groups: with and without medication. A questionnaire with 14 questions was applied, tracing the behavioral profile in relation to physical exercises before and during isolation, interpreted through descriptive analysis, and the groups were compared through Mann-Whitman's statistics.

A Time-Frequency Analysis for the Online Detection of the N2pc Event-Related Potential (ERP) Component in Individual EEG Datasets.

The N2pc event-related potential component measures direction and time course of selective visual attention and represents an important biomarker in cognitive neuroscience. While its subtractive origin strongly influences the amplitude, thus hindering its detection, other external factors, such as subject's inefficiency to allocate attention to the cued target, or the heterogeneity of the visual context, may strongly affect the elicitation of the component itself. It would therefore be extremely important to create a tool that, using as few sweeps as possible, could reliably establish whether an N2pc is present in an individual subject.

Bounds on Lorentz Invariance Violation from MAGIC Observation of GRB 190114C.

On January 14, 2019, the Major Atmospheric Gamma Imaging Cherenkov telescopes detected GRB 190114C above 0.2 TeV, recording the most energetic photons ever observed from a gamma-ray burst. We use this unique observation to probe an energy dependence of the speed of light in vacuo for photons as predicted by several quantum gravity models.

Computer data simulator to assess the accuracy of estimates of visual N2/N2pc event-related potential components.

Objective: Event-related potentials (ERPs) evoked by visual stimulations comprise several components, with different amplitudes and latencies. Among them, the N2 and N2pc components have been demonstrated to be a measure of subjects' allocation of visual attention to possible targets and to be involved in the suppression of irrelevant items. Unfortunately, the N2 and N2pc components have smaller amplitudes compared with those of the background electroencephalogram (EEG), and their measurement requires employing techniques such as conventional averaging, which in turn necessitates several sweeps to provide acceptable estimates.

A bilateral N2pc (N2pcb) component is elicited by search targets displayed on the vertical midline.

The study of visually elicited event-related potentials (ERPs) detected at posterior recording sites during visual search has enormously advanced our knowledge about how and when visuo-spatial attention locks onto one or more laterally presented target objects. The N2pc component to lateral targets has been pivotal to further our understanding of the mechanisms and time course of target selection in visual search. However, the N2pc cannot track visuo-spatial attention deployment to targets displayed along the vertical midline.

Emotion-related impulsivity moderates the cognitive interference effect of smartphone availability on working memory.

Although recent studies suggest that the mere presence of a smartphone might negatively impact on working memory capacity, fluid intelligence, and attentional processes, less is known about the individual differences that are liable to moderate this cognitive interference effect. This study tested whether individual differences in emotion-related impulsivity traits (positive urgency and negative urgency) moderate the effect of smartphone availability on cognitive performance. We designed an experiment in which 132 college students (age 18-25 years) completed a laboratory task that assessed visual working memory capacity in three different conditions: two conditions differing in terms of smartphone availability (smartphone turned off and visible, smartphone in silent mode and visible) and a condition in which the smartphone was not available and was replaced by a calculator (control condition).

Publisher Correction: Neural measures of the role of affective prosody in empathy for pain.

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.

Attentional Guidance from Multiple Working Memory Representations: Evidence from Eye Movements.

Recent studies have shown that the representation of an item in visual working memory (VWM) can bias the deployment of attention to stimuli in the visual scene possessing the same features. When multiple item representations are simultaneously held in VWM, whether these representations, especially those held in a non-prioritized or accessory status, are able to bias attention, is still controversial. In the present study we adopted an eye tracking technique to shed light on this issue.

N2pc reflects two modes for coding the number of visual targets.

Humans share with a variety of animal species the spontaneous ability to detect the numerical correspondence between limited quantities of visual objects and discrete auditory events. Here, we explored how such mental representation is generated in the visual modality by monitoring a parieto-occipital ERP component, N2pc, whose amplitude covaries with the number of visual targets in explicit enumeration. Participants listened to an auditory sequence of one to three tones followed by a visual search display containing one to three targets.

Multicomponent Exercise Improves Hemodynamic Parameters and Mobility, but Not Maximal Walking Speed, Transfer Capacity, and Executive Function of Older Type II Diabetic Patients.

The present study aimed to investigate the effects of a 6-month multicomponent exercise program (MCEP) on functional, cognitive, and hemodynamic parameters of older Type 2 diabetes mellitus (T2DM) patients. Moreover, additional analyses were performed to evaluate if T2DM patients present impaired adaptability in response to physical exercise when compared to nondiabetic volunteers. A total of 72 T2DM patients and 72 age-matched healthy volunteers (CG) were recruited and submitted to functional, cognitive, and hemodynamic evaluations before and after six months of a MCEP.

Neural measures of the role of affective prosody in empathy for pain.

Emotional communication often needs the integration of affective prosodic and semantic components from speech and the speaker's facial expression. Affective prosody may have a special role by virtue of its dual-nature; pre-verbal on one side and accompanying semantic content on the other. This consideration led us to hypothesize that it could act transversely, encompassing a wide temporal window involving the processing of facial expressions and semantic content expressed by the speaker.

Molecular Characterization of β-Thalassemia Mutations in Central Vietnam.

The molecular basis of β-thalassemia (β-thal) mutations in North and in South Vietnam have been described during the past 15 years, whereas limited data were available concerning the central area of the country. In this study, we describe the molecular characterization and frequency of β-globin gene mutations in the Thua Thien Hue Province of Central Vietnam as the result of a first survey conducted in 22 transfusion-dependent patients, and four unrelated heterozygotes. Nine different known mutations were identified (seven of the β and two of the β type) in a total of 48 chromosomes.

Backward masking interrupts spatial attention, slows downstream processing, and limits conscious perception.

The attentional blink (AB) is a difficulty in correctly processing a target when it follows one or more other targets after a short delay. When no backward mask is presented after the last critical target, there is no or little behavioral AB deficit. The mask plays an important role in limiting conscious access to target information.

Music therapy improves the mood of patients undergoing hematopoietic stem cells transplantation (controlled randomized study).

Purpose: The allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a therapeutic medical treatment for various neoplastic hematologic, congenital, genetic, or acquired disorders. In this procedure which combines high-dose chemotherapy and/or radiotherapy and has a high degree of cytotoxicity, the patient experiences solitary confinement, which causes psychological distress, pain, anxiety, mood disorders and can lead him/her to depression. Music therapy was applied with the purpose of decreasing this social confinement.

Psychological well-being and social support in chronic myeloid leukemia patients receiving lifelong targeted therapies.

Purpose: The main objective of this study was to investigate whether social support is independently associated with psychological well-being in chronic myeloid leukemia (CML) patients. Secondary objectives were to compare the psychological well-being profile of CML patients with that of their peers in general population and to examine possible age- and sex-related differences.

Patients And Methods: Analysis was performed on 417 patients in treatment with lifelong molecularly targeted therapies.

Enhanced frontal activation underlies sparing from the attentional blink: Evidence from human electrophysiology.

Using the ERP method, we examined the processing operations elicited by stimuli that appear within the same temporal attention window. Forty subjects searched for letter targets among digit distractors displayed in rapid serial visual presentation (RSVP). ERPs were examined under conditions where a single target was embedded among distractors and compared to those recorded when two consecutive targets were embedded among distractors.