A project co-created with the community to mitigate loneliness in midlife women.

This paper describes how a team of researchers, policy stakeholders and community members came together to co-create prevention-oriented and community-informed solutions to address loneliness in women-The Loneliness Project. Our aim is to encourage community partnerships and collective effort to address public health approaches to loneliness by developing a shared understanding of the issue from multiple perspectives and through the co-creation process, highlighting the key factors for co-creating a funding application for a community demonstration project.

Behavioral Assessment With the Coma Recovery Scale-Revised Is Safe and Feasible in Critically Ill Patients With Disorders of Consciousness.

Objectives: Accurate classification of disorders of consciousness (DoC) is key in developing rehabilitation plans after brain injury. The Coma Recovery Scale-Revised (CRS-R) is a sensitive measure of consciousness validated in the rehabilitation phase of care. We tested the feasibility, safety, and impact of CRS-R-guided rehabilitation in the ICU for patients with DoC after acute hemorrhagic stroke.

Toward Part-per-Million Precision in the Determination of an Ion's Collision Cross Section Using Multipass Cyclic Ion Mobility.

In cyclic ion mobility (cIMS), ions are permitted to travel multiple passes around the drift cell, increasing the distance traveled and the relative separation between ions. This study tests the hypothesis that multiple passes around the cell can also result in improved precision when measuring an ion's mobility and the collision cross section (CCS) derived therefrom. Experiments were performed with a diverse set of compounds, including 16 polycyclic aromatic hydrocarbons using gas chromatographic atmospheric pressure chemical ionization and a set of drug molecules by direct infusion electrospray ionization.

Size-Resolved Identification and Quantification of Micro/Nanoplastics in Indoor Air Using Pyrolysis Gas Chromatography-Ion Mobility Mass Spectrometry.

Humans are exposed to differing levels of micro/nanoplastics (MNPs) through inhalation, but few studies have attempted to measure <1 μm MNPs in air, in part due to a paucity of analytical methods. We developed an approach to identify and quantify MNPs in indoor air using a novel pyrolysis gas chromatographic cyclic ion mobility mass spectrometer (pyr-GCxcIMS). Four common plastic types were targeted for identification, namely, (polystyrene (PS), polyethylene (PE), polypropylene (PP), and polymethyl methacrylate (PMMA).

Toxicity and chemical composition of commercial road palliatives versus oil and gas produced waters.

Across the United States, road palliatives are applied to roads for maintenance operations that improve road safety. In the winter, solid rock salts and brine solutions are used to reduce the accumulation of snow and ice, while in the summer, dust suppressants are used to minimize fugitive dust emissions. Many of these products are chloride-based salts that have been linked to freshwater salinization, toxicity to aquatic organisms, and damage to infrastructure.

Nontargeted screening reveals fluorotelomer ethoxylates in indoor dust and industrial wastewater.

Concerns regarding the persistence, bioaccumulation behaviour, and toxicity of perfluorooctanoic acid and perfluorooctane sulfonic acid have resulted in the creation of thousands of replacement perfluoroalkyl substances (PFAS). This study reports on the discovery of fluorotelomer ethoxylates (FTEO) in indoor dust (9/15 samples), and industrial effluents (14/37 samples) using gas chromatographic cyclic ion mobility mass spectrometry (GC-cIMS). By filtering the detected unknowns by mass and collision-cross section, a series of FTEO homologues were revealed with the formula F-(CF)(CHO)H, where n = 6,8,10, and x = 4-12.

Unwrapping Wrap-around in Gas (or Liquid) Chromatographic Cyclic Ion Mobility-Mass Spectrometry.

Gas chromatography multiplexed with cyclic ion mobility mass spectrometry is a comprehensive two-dimensional separation technique that can resolve compounds that would otherwise coelute in a single-dimension separation. The cyclic geometry of the ion mobility cell enables ions to travel multiple passes, increasing their drift times to the detector and relative separation. However, the quality of the separation may be obfuscated when "wrap-around" occurs, during which speedier ions catch up with slower ion populations when allowed to travel through more than one pass.

Gas Chromatography-(Cyclic) Ion Mobility Mass Spectrometry: A Novel Platform for the Discovery of Unknown Per-/Polyfluoroalkyl Substances.

Per- and polyfluoroalkyl substances (PFASs) have been widely used since the 1940s in industry and everyday household products. They also persist in the environment and bioaccumulate in humans and wildlife. Despite these concerns, the identities of most PFASs in environmental and biological samples are unknown.

Nontargeted Screening Using Gas Chromatography-Atmospheric Pressure Ionization Mass Spectrometry: Recent Trends and Emerging Potential.

Gas chromatography-high-resolution mass spectrometry (GC-HRMS) is a powerful nontargeted screening technique that promises to accelerate the identification of environmental pollutants. Currently, most GC-HRMS instruments are equipped with electron ionization (EI), but atmospheric pressure ionization (API) ion sources have attracted renewed interest because: (i) collisional cooling at atmospheric pressure minimizes fragmentation, resulting in an increased yield of molecular ions for elemental composition determination and improved detection limits; (ii) a wide range of sophisticated tandem (ion mobility) mass spectrometers can be easily adapted for operation with GC-API; and (iii) the conditions of an atmospheric pressure ion source can promote structure diagnostic ion-molecule reactions that are otherwise difficult to perform using conventional GC-MS instrumentation. This literature review addresses the merits of GC-API for nontargeted screening while summarizing recent applications using various GC-API techniques.

Targeted and non-targeted analysis of young-of-year smallmouth bass using comprehensive two-dimensional gas chromatography coupled with time-of-flight mass spectrometry.

Smallmouth bass in the Susquehanna River Basin, Chesapeake Bay Watershed, USA, have been exhibiting clinical signs of disease and reproductive endocrine disruption (e.g., intersex, male plasma vitellogenin) for over fifteen years.

Determination of contaminants of emerging concern and their transformation products in treated-wastewater irrigated soil and corn.

In many parts of the world, clean water has become increasingly scarce. Irrigation of agricultural land with treated wastewater is commonly used in response to water shortages but there is concern about the environmental fate and transport of contaminants present in the irrigation wastewater. This study aimed to examine the presence of wastewater sourced contaminants in soil and field grown corn (Zea mays) crops spray irrigated with treated wastewater.

A comparison of liquid-liquid extraction and stir bar sorptive extraction for multiclass organic contaminants in wastewater by comprehensive two-dimensional gas chromatography time of flight mass spectrometry.

Liquid-liquid extraction (LLE) and stir bar sorptive extraction (SBSE) are extraction methods used for the analysis of contaminants in aqueous samples. In this study, both LLE and SBSE were compared for the extraction of priority pollutants and contaminants of emerging concern (CECs) in wastewater influent and effluent samples, for analysis with comprehensive two-dimensional gas chromatography with time of flight mass spectrometry (GC × GC-TOFMS). The methods were compared for their extraction efficiency of a broad range of compounds, matrix effects, accurate and reliable quantification of targets, and sensitivity.

Forensic tracers of exposure to produced water in freshwater mussels: a preliminary assessment of Ba, Sr, and cyclic hydrocarbons.

Hydraulic fracturing is often criticized due in part to the potential degradation of ground and surface water quality by high-salinity produced water generated during well stimulation and production. This preliminary study evaluated the response of the freshwater mussel, Elliptio complanata, after exposure to produced water. A limited number of adult mussels were grown over an 8-week period in tanks dosed with produced water collected from a hydraulically fractured well.

A suspect screening analysis for contaminants of emerging concern in municipal wastewater and surface water using liquid-liquid extraction and stir bar sorptive extraction.

The presence of contaminants of emerging concern (CECs) in wastewater effluent and surface waters is an important field of research for analytical scientists. This study takes a suspect screening approach to wastewater and surface water analysis using comprehensive two-dimensional gas chromatography with time-of-flight mass spectrometry (GC × GC-TOFMS). Two extraction procedures, traditional liquid-liquid extraction (LLE) and stir bar sorptive extraction (SBSE), were utilized and evaluated for their application to wastewater and surface water samples.

Comprehensive two-dimensional gas chromatography thermodynamic modeling and selectivity evaluation for the separation of polychlorinated dibenzo-p-dioxins and dibenzofurans in fish tissue matrix.

Comprehensive two-dimensional gas chromatography (GC×GC) is a powerful tool for complex separations. The selectivity and sensitivity benefits from thermally modulated GC×GC were applied to the analysis of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs). Thermodynamic indices of 50 PCDD/Fs, including the 17 toxic 2378-substituted congeners, were collected and used to model one-dimensional and two-dimensional separations with the Rtx-Dioxin2 and Rxi-17SilMS capillary GC columns.

The Rtx-Dioxin2 and Rxi-17SilMS as Alternative Gas Chromatographic Confirmation Columns for Dioxin Analysis.

Polychlorinated dibenzo-p-dioxins and furans are environmentally persistent and highly toxic compounds. 136 chlorinated dioxins and furan congeners contain at least four chlorine atoms and pose a complex separation challenge in environmental and biological matrixes. The complexity arises from the dioxin and furan molecules with substitutions at positions 2, 3, 7, and 8, which are toxicologically relevant but are not easily separated from the other non-/less toxic congeners.

Modified QuEChERS extraction for the analysis of young-of-year smallmouth bass using GC × GC-TOFMS.

Signs of disease, such as external lesions, have been prevalent in smallmouth bass throughout the Susquehanna River Basin, USA. Previous targeted chemical studies in this system have identified known persistent organic pollutants, but a common explanatory link across multiple affected sites remains undetermined. A fast and robust extraction method that can be applied to young-of-year fish is needed to effectively screen for target and non-target compounds that may be impacting organism health.

Thermodynamic modeling of comprehensive two dimensional gas chromatography isovolatility curves for second dimension retention indices based analyte identification.

A method to thermodynamically model the alkane isovolatility curves of a comprehensive two dimensional gas chromatography (GC × GC) separation is presented. This method omits all instrument modifications, additional chromatogram collection, or method alterations which typical isovolatility curve generation requires. Provided that the thermodynamic indices of reference alkanes are available, chromatographers only need to specify the GC × GC method parameters of their separation to output the isovolatility curves.

Retention time prediction of hydrocarbons in cryogenically modulated comprehensive two-dimensional gas chromatography: A method development and translation application.

Thermodynamic modeling of GC × GC separations provides a tool for rapid method evaluation and optimization. Separations of 95 hydrocarbons on two cryogenically modulated GC × GC systems (atmospheric outlet and vacuum outlet) are modeled, displaying average second dimension retention time modeling absolute errors of 0.17 s and 0.

Characterization of 9 gas chromatography columns by Kovats and Lee retention indices for dioxin analysis.

Polychlorinated dibenzo-p-dioxins and furans offer a complex separation challenge due to their chemical similarity and 5020 possible congeners, including the Br/Cl congeners. Not only are these compounds difficult to separate, but they are also difficult to identify. Expensive reference materials are needed for conventional "dioxin analysis", usually requiring C labeled and native compounds.

Detection and removal of biologically active organic micropollutants from hospital wastewater.

The presence of contaminants of emerging concern (CECs), such as antibiotics, antimicrobial disinfectants, nonprescription drugs, personal care products, pharmaceuticals, and steroids, in water resources can impact aquatic and human health. A large portion of the CECs entering regional wastewater treatment plants originate from hospitals. The purposes of this study were to conduct exploratory analytical work to characterize two hospital wastewaters and to evaluate treatment of CECs at hospitals before dilution with domestic wastewater.

Characterization and quantification of methyl-benzotriazoles and chloromethyl-benzotriazoles produced from disinfection processes in wastewater treatment.

Wastewater treatment plants (WWTPs) are one of the major sources of contaminants of emerging concern (CECs) in the environment. Benzotriazole corrosion inhibitors are a class of CECs that are resistant to biodegradation and have been reported in waters varying from WWTP effluent to groundwater and drinking water. This study examined wastewater influent and effluent grab samples over three years using Comprehensive Two-Dimensional Gas Chromatography (GC × GC) to discover six target benzotriazoles, four of which have never been properly characterized in water prior to this work.

Rapid Screening of Complex Matrices: Utilizing Kendrick Mass Defect To Enhance Knowledge-Based Group Type Evaluation of Multidimensional Gas Chromatography-High-Resolution Time-of-Flight Mass Spectrometry Data.

Organic compound characterization of highly complex matrices involves scientific challenges, such as the diversity of "true" unknowns, the concentration ranges of various compound classes, and limited available amounts of sample. Therefore, discovery-based multidimensional gas chromatography coupled to high-resolution time-of-flight mass spectrometry (GC×GC-HRToFMS) is increasingly applied. Nevertheless, most studies focus on target analysis and tend to disregard important details of the sample composition.