[Sitaglitpin phosphate treatment in patients with reactive hypoglycemia secondary to dysinsulinism. Controlled, randomized, double-blind study].

Objective: We evaluated the effect of sitagliptin in correction of symptomatic reactive hypoglycemia.

Methods: Randomized, double blind, placebo-controlled clinical trial. Thirteen patients treated with sitagliptin and 15 with placebo, with mean age of 34.

High adiponectin concentrations are associated with the metabolically healthy obese phenotype.

Context: In the ob/ob mice, keeping adiponectin concentrations in the physiological range (through overexpression of this gene in the adipose tissue) results in expansion of fat mass and protection against metabolic co-morbidities.

Objective: The aim of the study was to test in humans whether plasma adiponectin levels, similar to those found in lean subjects, are associated with the metabolically healthy obese phenotype.

Design And Setting: A cross-sectional analysis was performed of a cohort of obese and nonobese subjects aged 18-70 yr.