Quantification of smooth pursuit dysfunction in multiple sclerosis.

Background: Smooth pursuit dysfunction is common in MS, but rarely quantified and may be missed on exam.

Methods: NeuroFitONE™ smooth pursuit performance measures were compared between MS (n = 20) and healthy control (n = 19) participants.

Results: Compared to controls, MS patients had lower proportion of smooth pursuit (0.

Oculometric Assessment of Sensorimotor Impairment Associated with TBI.

Purpose: Diffuse tissue damage from impact or blast traumatic brain injury (TBI) degrades information processing throughout the brain, often resulting in impairments in sensorimotor function. We have developed an eye-movement assessment test, consisting of a simple, appropriately randomized, radial tracking task together with a broad set of oculometric measures that can be combined to yield a sensitive overall indicator of sensorimotor functional status. We show here that this multidimensional method can be used to detect and characterize sensorimotor deficits associated with TBI.

Redundancy reduction explains the expansion of visual direction space around the cardinal axes.

Motion direction discrimination in humans is worse for oblique directions than for the cardinal directions (the oblique effect). For some unknown reason, the human visual system makes systematic errors in the estimation of particular motion directions; a direction displacement near a cardinal axis appears larger than it really is whereas the same displacement near an oblique axis appears to be smaller. Although the perceptual effects are robust and are clearly measurable in smooth pursuit eye movements, all attempts to identify the neural underpinnings for the oblique effect have failed.

Oculometric assessment of dynamic visual processing.

Eye movements are the most frequent (∼3/s), shortest-latency (∼150-250 ms), and biomechanically simplest (one joint, no inertial complexities) voluntary motor behavior in primates, providing a model system to assess sensorimotor disturbances arising from trauma, fatigue, aging, or disease states. We have developed a 15-min behavioral tracking protocol consisting of randomized Rashbass (1961) step-ramp radial target motion to assess several aspects of the behavioral response to visual motion, including pursuit initiation, steady-state tracking, direction tuning, and speed tuning. We show how oculomotor data can be converted into direction- and speed-tuning oculometric functions, with large increases in efficiency over traditional button-press psychophysics.

G-loading and vibration effects on heart and respiration rates.

Background: Operational environments expose pilots and astronauts to sustained acceleration (G loading) and whole-body vibration, alone and in combination. Separately, the physiological effects of G loading and vibration have been well studied; both have effects similar to mild exercise. The few studies of combined G loading and vibration have not reported an interaction between these factors on physiological responses.

Onset of positional vertigo during exposure to combined G loading and chest-to-spine vibration.

Background: Aerospace environments commonly expose pilots to vibration and sustained acceleration, alone and in combination.

Case Reports: Of 16 experimental research participants, 3 reported symptoms of vertigo and signs of torsional nystagmus during or shortly following exposure to sustained chest-to-spine (+3.8 Gx) acceleration (G loading) and chest-to-spine (0.

Saccadic brightness decisions do not use a difference model.

Eye movements are the most frequent (∼3 per second), shortest-latency (∼150-250 ms), and biomechanically simplest (1 joint, no inertial complexities) voluntary motor behavior in primates, providing a model sensorimotor decision-making system. Current computational "difference" models of choice behavior utilize a single decision variable encoding the difference between two alternate signals, often implemented as a log-likelihood ratio. Alternatively, the oculomotor literature describes a "race" mechanism, in which two separate decision variables encoding the two alternate signals race against one another independently.

Rethinking human visual attention: spatial cueing effects and optimality of decisions by honeybees, monkeys and humans.

Visual attention is commonly studied by using visuo-spatial cues indicating probable locations of a target and assessing the effect of the validity of the cue on perceptual performance and its neural correlates. Here, we adapt a cueing task to measure spatial cueing effects on the decisions of honeybees and compare their behavior to that of humans and monkeys in a similarly structured two-alternative forced-choice perceptual task. Unlike the typical cueing paradigm in which the stimulus strength remains unchanged within a block of trials, for the monkey and human studies we randomized the contrast of the signal to simulate more real world conditions in which the organism is uncertain about the strength of the signal.

Effects of prior information and reward on oculomotor and perceptual choices.

Expectations about the environment influence motor behavior. In simple tasks, for example, prior knowledge about which stimulus event will likely occur or which response will likely be rewarded induces a tendency to take the favored action (i.e.

Shared decision signal explains performance and timing of pursuit and saccadic eye movements.

Each voluntary eye movement provides physical evidence of a visuomotor choice about where and when to look. Primates choose visual targets with two types of voluntary eye movements, pursuit and saccades, although the exact mechanism underlying their coordination remains unknown. Are pursuit and saccades guided by the same decision signal? The present study compares pursuit and saccadic choices using techniques borrowed from psychophysics and models of response time.

Target selection and the superior colliculus: goals, choices and hypotheses.

The intermediate and deep layers of the superior colliculus (SC) compose a retinotopically organized motor map and are known to be important for the control of saccadic eye movements. However, recent studies have shown that the functions of the SC are not restricted to the motor control of saccades. The pattern of activity observed during multi-saccade movements, combined eye-head movements, and pursuit eye movements argue that activity in the SC indicates the location of the goal, but does not specify the particular movements that will be used to acquire the goal.

Shared response preparation for pursuit and saccadic eye movements.

Tracking a single target in the visual world requires coordination between pursuit and saccadic eye movements. The constraints imposed on pursuit and saccade decisions by visual processing and response preparation are difficult to compare because latency differences between the two movements provide different amounts of visual sampling time. The present study compares pursuit and saccade decisions when visual processing was directly manipulated.