Publications by authors named "Dorian Teissandier"
Background: The incidence of cardiovascular diseases is increasing in persons with hemophilia A (HA). Therefore, anticoagulant therapy based on direct oral anticoagulants (DOACs) may be needed, despite the bleeding risk. In case of surgery or bleeding, such patients may be concomitantly treated with emicizumab (routine prophylaxis), factor (F)VIII products, and DOAC.
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- Diagnosing pulmonary embolism (PE) in the emergency department can be tricky because it involves different steps and tests.
- Doctors check for symptoms like chest pain or shortness of breath and use specific rules to decide if a patient might have PE.
- If they think someone is likely to have PE, they do imaging tests, while lower-risk patients might just need a D-dimer blood test to help figure things out.
Article Synopsis
- The study aimed to evaluate how well the Pulmonary Embolism Rule-out Criteria (PERC) and the age-modified PERC-35 tool perform in emergency departments for patients aged 35 and younger suspected of having a pulmonary embolism (PE).
- Data from 1,235 patients indicated that while both PERC and PERC-35 could rule out PE in nearly half the cases, there were still a few missed diagnoses.
- Results showed that both tools had similar safety and efficacy, but the research couldn't definitively confirm their reliability due to large confidence intervals.
Article Synopsis
- - Tracheal intubation is typically advised for coma patients, but its effectiveness in those with acute poisoning remains unclear; a study aimed to evaluate whether withholding intubation would affect outcomes for these patients.
- - The multicenter randomized trial took place across 20 emergency departments and 1 ICU in France and involved 225 comatose patients with severe poisoning, comparing a conservative approach to standard intubation practices.
- - Results indicated that patients in the conservative treatment group had better clinical outcomes, lower intubation rates, fewer adverse events, and a reduced incidence of pneumonia compared to those receiving routine intubation.
Article Synopsis
- Older patients (≥75 years) waiting overnight in emergency departments (ED) for hospital admission may face higher in-hospital mortality risks and adverse health events compared to those admitted before midnight.
- A study involving 1598 older patients in France found that those who spent the night in the ED had a mortality rate of 15.7% compared to 11.1% for those admitted earlier.
- Patients in the ED group also experienced more adverse events and had a longer median hospital stay (9 days compared to 8 days for the ward group).
Background: Bleeding during oral anticoagulant therapy is currently codified by expert guidelines. Monitoring of coagulation during bleeding events is challenging. Our study sought to assess thrombin generation assay (TGA) in direct oral anticoagulant-treated patients without bleeding (WB), bleeding without reversal therapy (BR-), and bleeding with reversal therapy (BR+).
View Article and Find Full Text PDFIdarucizumab has been included in guidelines for the management of bleeding or surgical procedure in dabigatran-treated patients without need for biological monitoring. The aim of the study was to assess the prognostic value of dabigatran plasma level before reversal to test the hemostatic efficacy of idarucizumab. The secondary objectives were (i) to analyze plasma dabigatran level according to the risk of rebound and (ii) to evaluate the incidence of post-reversal non-favorable clinical outcomes (including thromboembolism, bleeding, antithrombotic, and death) and antithrombotic resumption.
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- The study investigated how epicatechin, a flavonoid known for cardiovascular benefits, affects the structure and permeability of fibrin clots, which are important in thromboembolic diseases.
- Researchers analyzed plasma samples from 12 healthy individuals by measuring turbidity, fibrin fiber sizes, and permeability after adding varying concentrations of epicatechin.
- The results indicated that epicatechin made fibrin clots less dense and more permeable, with statistically significant changes in fiber size and distance between protofibrils at certain concentrations.
Introduction: Hemorrhage occurs in 7-10% of patients treated with vitamin K antagonist (VKA), with major bleeding in 1-3%. Impact of nutritional status on the bleeding risk of patients on anticoagulants is still poorly documented. Our study aimed to analyze the link between the nutritional status of patients on VKA and the occurrence of hemorrhagic events.
View Article and Find Full Text PDFMicroparticles play a role in cardiovascular disease pathology. The flavanol-like epicatechin is increasingly considered due to its cardioprotective effects. The aim of this study was to investigate the impact of epicatechin on microparticle generation, phenotype and procoagulant properties.
View Article and Find Full Text PDFThe different stages of hemostasis (i.e., primary hemostasis, coagulation and fibrinolysis) are involved in the early atherothrombosis steps.
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