Publications by authors named "Doreen Nuwashaba"
Biomarkers including Forkhead/winged-helix transcription factor box P3 have been proposed in immunohistochemical techniques to diagnose cervical lesions, but can be objectively quantified and measured in blood using methods that can be standardised. In this study we quantified the serum FOXP3 concentrations and assessed their association with cervical lesions at the cervical cancer clinic of Mbarara Regional Hospital (MRRH) Southwestern Uganda. We performed secondary analysis on archived serum samples from a previous unmatched case control study in which we recruited 90 cervical cancer (CC) cases, 90 cervical intraepithelial neoplasia (CIN) cases before any form of treatment and 90 controls.
View Article and Find Full Text PDFAssociation between serum P16ink4A concentration and CIN and cervical cancer among women attending a cervical cancer clinic in western Uganda: A case control study.
Frank Ssedyabane Joseph Ngonzi Deusdedit Tusubira Josephine Nambi Najjuma Rogers Kajabwangu Doreen Nuwashaba
Gynecol Oncol Rep
June 2024
Article Synopsis
- - The study explored the relationship between serum P16ink4A levels and cervical lesions in women at a clinic in Uganda, involving 90 cases each of cervical intraepithelial neoplasia (CIN), cervical cancer (CC), and controls.
- - Results indicated that average serum P16ink4A concentrations were higher in CC patients compared to CIN cases and controls, with some correlations noted, although statistically insignificant for CIN.
- - The findings suggest that serum P16ink4A may help identify cervical lesions, particularly CC, indicating a potential for future diagnostic applications in detecting cervical cancer.