Publications by authors named "Doreen Jacob"
Article Synopsis
- Liquid chromatography tandem mass spectrometry (LC-MS/MS) is the standard method for measuring immunosuppressive drugs (ISDs), but it's difficult to access in low-resource areas; this study evaluates the Roche electrochemiluminescence immunoassay (ECLIA) for cyclosporine, everolimus, and sirolimus against LC-MS/MS in an African population.* -
- The study compared ECLIA measurements to LC-MS/MS in samples from 132 patients, showing a strong correlation for all ISDs (Pearson's r > 0.94), with specific slopes and y-intercepts indicating varying degrees of accuracy for each drug.* -
- While ECLIA for cyclospor
Objective: The aim of this study was to determine the impact of the COVID-19 pandemic on test requests for the diagnosis and routine care of patients with various non-communicable diseases (NCD) across South Africa (SA).
Methods: A retrospective audit of laboratory test requests received from hospital outpatient departments and primary healthcare facilities across SA was performed. The following analytes were studied: glycated hemoglobin (HbA1c), lipids profiles, thyroid-stimulating hormone (TSH), and thyroxine (fT4), as well as triiodothyronine (fT3), serum protein electrophoresis (SPE), serum free light chains (SFLC), and prostate specific antigen (PSA); these tests were used as a proxy of NCD detection and follow-up.
Communication between functional and denervated muscles using radiofrequency.
Otolaryngol Head Neck Surg
May 2006
Objective: This article focuses on establishing communication between a functional muscle and a denervated muscle using a radiofrequency communications link. The ultimate objective of the project is to restore the eye blink in patients with facial nerve paralysis.
Study Design And Setting: Two sets of experiments were conducted using the gastrocnemius leg muscles of Sprague-Dawley rats.