Antimalarial Susceptibility of and Isolates to Selected Antimalarial Agents, Column Chromatographic Subfractions of Leaves Extract and FTIR and GCMS of SF8.

Malaria still remains a life-threatening parasitic disease with universal targets set for control and elimination. This study aimed to evaluate the antimalarial susceptibility of isolates and to selected antimalarial agents and column chromatographic subfractions of leaves extract and FTIR and GCMS of SF8. Trager and Jensen as well as World Health Organisation (WHO) standardised micro-test system methods were used to determine susceptibility on the patients' blood samples; Column chromatographic procedure was carried out to obtain 11 pooled fractions; FTIR and GCMS were used to determine functional groups and phytochemicals respectively.

Antidiabetic, Antioxidant and Anti-Inflammatory Activities of Residual Aqueous Fraction of in Induced Type 2 Diabetic Rats.

Oxidative stress and inflammation have been proven to be implicated in the pathogenesis of type 2 diabetes. Recent studies showed that had antioxidant activity. This study investigated the antidiabetic, antioxidant, and anti-inflammatory potential of the residual aqueous fraction of in type 2 diabetic-induced male rats.

Isolation and Structural Elucidation of Novel Antidiabetic Compounds from Leaves of Linn and (Pers) Decne.

The antihyperglycemic effect of the polyherbal combination of the leaves of Linn (MB) and (pers) Decne (LH) have been reported in our previous study in addition to its documented dietary usages. However, the bioactive principles are yet to be fully elucidated. In the present study, bioactive antidiabetic compounds from the leaf extracts of Linn and (pers) Decne were isolated and characterized.

Bioguided fractionation of hypoglycaemic component in methanol extract of an study.

Nine components (C1-C9) were isolated from chloroform fraction of fractionated methanol extracts of leaves (FMEVA) by column chromatography. All the components C1 to C9 were purified and screened for hypoglycaemic activities in type-2 diabetic rats. The most potent hypoglycaemic component was elucidated on the basis of extensive spectroscopic (1D-, 2D-NMR, GC-MS, FTIR) data analysis.

Leaves Extract Ameliorates Alterations Associated with 7, 12-Dimethyl Benz[a]Anthracene-Induced Mammary Damage in Female Wistar Rats.

leaves are used traditionally in West Africa for the treatment of swellings and cancer. We investigated if leaves extract could ameliorate 7, 12-dimethylbenz[a]anthracene (DMBA)-induced mammary damage. Female Wistar rats aged 52 ± 2 day were administered 80 mg/kg DMBA.

Phytochemical analysis, antioxidant and anti-inflammatory potential of FERETIA APODANTHERA root bark extracts.

Background: Inflammation has been implicated in many disorders, including cancer and available therapies elicit adverse effects. Plants of the family Rubiaceae have shown potency against inflammation. The anti-inflammatory and anti-oxidant potential of Feretia apodanthera was investigated in this study to evaluate its effectiveness.

Anti-Diabetic Potential of Ocimum gratissimum Leaf Fractions in Fortified Diet-Fed Streptozotocin Treated Rat Model of Type-2 Diabetes.

: (OG) is used in the traditional management of diabetes in Nigeria. This study investigated the anti-diabetic potential of OG leaf fractions (OGLF) in a rat model of Type-2 diabetes (T2D). : Methanol crude extract of OG leaf was fractionated with solvents of increasing order of polarity (-hexane, chloroform, ethyl-acetate, -butanol and water).

Appropriate Insulin Level in Selecting Fortified Diet-Fed, Streptozotocin-Treated Rat Model of Type 2 Diabetes for Anti-Diabetic Studies.

Background: Pathophysiological investigation of disease in a suitable animal model is a classical approach towards development of a credible therapeutic strategy. This study examined appropriate insulin level in selecting animal model for type 2 diabetes (T2D) studies.

Method: Albino Wistar rats (150-200g) were divided into two groups fed with commercially available normal-diet-feed (NDF) and water or fortified diet feed (FDF) (10g NDF per gram of margarine) with 20% fructose solution as drinking water.

Oxidative Stress and Carcinogenesis: Potential of Phytochemicals in Breast Cancer Therapy.

Breast cancer remains a burden in both developed and developing countries, with higher mortality in developing countries. Attempts to eradicate cancer have not been successful despite the progress made in the development of more novel chemotherapeutic drugs. Reactive-oxygen-species-mediated oxidative stress is known to play a role in breast cancer pathogenesis via genetic and epigenetic modifications, resulting in uncontrolled cell proliferation.

Evaluation of extraction protocols for anti-diabetic phytochemical substances from medicinal plants.

Aim: To examine the efficacy of three extraction techniques: Soxhlet-extraction (SE), cold-maceration (CM) and microwave-assisted-extraction (MAE) using 80% methanol as solvent.

Methods: The study was performed on each of 50 g of (VA) and (OG) leaves respectively. The percentage yield, duration of extraction, volume of solvent used, qualitative and quantitative phytoconstituents present was compared.

Sickled Erythrocytes Reversal and Membrane Stabilizing Compounds in Telfairia occidentalis.

Background and Purpose. Traditional management of sickle cell disease (SCD) is ubiquitous in Africa. In south-eastern Nigeria, Telfairia occidentalis (T.