Predicting Bubble Fragmentation in Superfluids.

In classical fluids, the Weber number is a dimensionless parameter that characterizes the flow of a multiphase fluid. The superfluid analogy of a classical multiphase fluid can be realized in a system of two or more immiscible Bose-Einstein condensates. These superfluid mixtures have been shown to display a wider variety of exotic dynamics than their single component counterparts.

Do neuroticism and efficacy beliefs moderate the relationship between climate change worry and mental wellbeing?

Background: Research on the nature and prevalence of phenomena like climate anxiety (or eco-anxiety) is increasing rapidly but there is little understanding of the conditions under which climate change worry becomes more or less likely to significantly impact mental wellbeing. Here, we considered two plausible moderators of the relationship between climate change worry and mental wellbeing: neuroticism and efficacy beliefs.

Methods: Analysis was conducted with survey data gathered in six European countries in autumn 2019.

A comparison of cenobamate with other newer antiseizure medications for adjunctive treatment of focal-onset seizures: A systematic review and network meta-analysis.

Purpose: To compare the efficacy, safety, and tolerability of cenobamate with other newer anti-seizure medications (ASMs) including brivaracetam, eslicarbazepine, lacosamide, perampanel, and zonisamide, approved for adjunctive treatment of drug-resistant focal-onset seizures (FOS) in adults with epilepsy.

Methods: A systematic literature review (SLR) was conducted to obtain relevant efficacy, safety, and tolerability data for ASMs for the treatment of drug-resistant FOS. All studies were thoroughly assessed for potential sources of heterogeneity and analysed via Bayesian network meta-analyses (NMAs).

A discrete choice experiment to elicit preferences for a liver screening programme in Queensland, Australia: a mixed methods study to select attributes and levels.

Background: In Australia, the overall prevalence of liver disease is increasing. Maximising uptake of community screening programmes by understanding patient preferences is integral to developing consumer-centred care models for liver disease. Discrete choice experiments (DCEs) are widely used to elicit preferences for various healthcare services.

Emotional reactions to climate change: a comparison across France, Germany, Norway, and the United Kingdom.

We present a study of emotional reactions to climate change utilizing representative samples from France, Germany, Norway, and the United Kingdom (UK). Drawing on appraisal theories of emotion, we examine relations between appraisals, emotions, and behavioral intentions in the context of climate change. We compare the four countries concerning emotional differences and commonalities and relate our findings to pertinent models of cultural values.

Expected climate change consequences and their role in explaining individual risk judgments.

This study examines what individuals expect will be the most important impacts of climate change on their respective countries, and how these expectations relate to individual risk judgments. Open-ended responses from representative samples in four European countries (each n > 1000), were sorted into six categories: expectations of climate change leading to changes in attitudes and goals, human activities, emissions and pollution, environmental changes, impacts on humans, or few or no impacts. The results showed that the most frequently mentioned climate change impacts were related to environmental changes.

Stratified glucose-lowering response to vildagliptin and pioglitazone by obesity and hypertriglyceridemia in a randomized crossover trial.

Background: Understanding which group of patients with type 2 diabetes will have the most glucose lowering response to certain medications (which target different aspects of glucose metabolism) is the first step in precision medicine.

Aims: We hypothesized that people with type 2 diabetes who generally have high insulin resistance, such as people of Māori/Pacific ethnicity, and those with obesity and/or hypertriglyceridemia (OHTG), would have greater glucose-lowering by pioglitazone (an insulin sensitizer) versus vildagliptin (an insulin secretagogue).

Methods: A randomised, open-label, two-period crossover trial was conducted in New Zealand.

Depletion of COPI in cancer cells: the role of reactive oxygen species in the induction of lipid accumulation, noncanonical lipophagy and apoptosis.

The coatomer protein complex 1 (COPI) is a multisubunit complex that coats intracellular vesicles and is involved in intracellular protein trafficking. Recently we and others found that depletion of COPI complex subunits zeta (COPZ1) and delta (ARCN1) preferentially kills tumor cells relative to normal cells. Here we delineate the specific cellular effects and sequence of events of COPI complex depletion in tumor cells.

Comparing the motivational underpinnings of sustainable consumption across contexts using a scenario-based approach.

A sample of tourists ( = 780) responded to a survey addressing purchasing intentions and consumption motives in relation to buying sustainable groceries at a local food market. These intentions and motives were contrasted for two consumption contexts: on vacation vs. at home.

What does the public think about microplastics? Insights from an empirical analysis of mental models elicited through free associations.

Microplastics are an issue of rising concern, in terms of their possible implications for both the environment and human health. A survey was distributed among a representative sample of the adult Norwegian population ( = 2720) to explore the public understanding of microplastics. Respondents were asked to report the first thing that came to mind when they read or heard the word "microplastics," based on which a coding scheme was developed that served to categorize the obtained answers into thematic clusters.

Did concern about COVID-19 drain from a 'finite pool of worry' for climate change? Results from longitudinal panel data.

According to the 'finite pool of worry' hypothesis, one may expect that introducing a novel concern (e.g., about a pandemic) may reduce concern about an existing issue (e.

Expectation of others' cooperation, efficacy beliefs, and willingness to sacrifice personal interests for the environment.

This paper departs from the view that the social dilemma literature provides a useful framework to delineate possible barriers to the adoption of environmentally friendly lifestyles. One domain in which tensions between personal and collective interests might occur are travel decisions in the context of tourism, where it has been shown that even those people who are very committed to environmental practices at home tend to reduce respective commitments on vacation. Data from a cross-sectional survey N = 771 were analyzed to investigate if the expectation that other tourists travel environmentally friendly can in part explain individual travel decisions with environmental implications.

Genomic variation in captive deer mouse (Peromyscus maniculatus) populations.

Background: Deer mice (genus Peromyscus) are the most common rodents in North America. Despite the availability of reference genomes for some species, a comprehensive database of polymorphisms, especially in those maintained as living stocks and distributed to academic investigators, is missing. In the present study we surveyed two populations of P.

Investigation of the Anti-Methicillin-Resistant Activity of (+)-Tanikolide- and (+)-Malyngolide-Based Analogues Prepared by Asymmetric Synthesis.

Herein, we report antibacterial and antifungal evaluation of a series of previously prepared (+)-tanikolide analogues. One analogue, (4,6)-4-methyltanikolide, displayed promising anti-methicillin-resistant activity with a MIC of 12.5 µg/mL.

Outcome expectancies moderate the association between worry about climate change and personal energy-saving behaviors.

This paper explores whether efficacy beliefs can alter the relationship between worry about climate change and personal energy-saving behaviors, controlling for climate change beliefs and socio-demographics. For this purpose, we used data from 23 countries that participated in the European Social Survey Round 8 (N = 44 387). Worry about climate change, personal efficacy, personal outcome expectancy, and collective outcome expectancy were each associated with personal energy-saving behaviors concerning either energy curtailment or energy efficiency.

Understanding teacher design practices for digital inquiry-based science learning: the case of Go-Lab.

Designing and implementing online or digital learning material is a demanding task for teachers. This is even more the case when this material is used for more engaged forms of learning, such as inquiry learning. In this article, we give an informed account of Go-Lab, an ecosystem that supports teachers in creating Inquiry Learning Spaces (ILSs).

Numerical method for the projected Gross-Pitaevskii equation in an infinite rotating two-dimensional Bose gas.

We present a method for evolving the projected Gross-Pitaevskii equation in an infinite rotating Bose-Einstein condensate, the ground state of which is a vortex lattice. We use quasiperiodic boundary conditions to investigate the behavior of the bulk superfluid in this system, in the absence of boundaries and edge effects. We also give the Landau gauge expression for the phase of a BEC subjected to these boundary conditions.

Political Orientation Moderates the Relationship Between Climate Change Beliefs and Worry About Climate Change.

Public perceptions are well established as a key factor in support for climate change mitigation policies, and they tend to vary both within and between countries. Based on data from the European Social Survey Round 8 ( = 44,387), we examined the role of climate change beliefs and political orientation in explaining worry about climate change across 23 countries. We show that belief in anthropogenic climate change, followed by expectations of negative impacts from climate change, are the strongest predictors of worry about climate change.

The key role of terminators on the expression and post-transcriptional gene silencing of transgenes.

Transgenes have become essential to modern biology, being an important tool in functional genomic studies and also in the development of biotechnological products. One of the major challenges in the generation of transgenic lines concerns the expression of transgenes, which, compared to endogenes, are particularly susceptible to silencing mediated by small RNAs (sRNAs). Several reasons have been put forward to explain why transgenes often trigger the production of sRNAs, such as the high level of expression induced by commonly used strong constitutive promoters, the lack of introns, and features resembling viral and other exogenous sequences.

Plin-amiR, a pre-microRNA-based technology for controlling herbivorous insect pests.

The cotton bollworm, Helicoverpa armigera, is a major insect pest for a wide range of agricultural crops. It causes significant yield loss through feeding damage and by increasing the crop's vulnerability to bacterial and fungal infections. Although expression of Bacillus thuringiensis (Bt) toxins in transgenic crops has been very successful in protecting against insect pests, including H.

Complexity and Simplification in Understanding Travel Preferences Among Tourists.

Travel preferences are complex phenomena, and thus cumbersome to deal with in full width in diagnostic and strategic planning processes. The aim of the present investigation was to explore to what extent individual preferences can be simplified into structures, and if tourists can be grouped into preference clusters that are viable and practically applicable for tourism planning. Building on prior studies that have validated survey instruments designed to measure different tourist role orientations, we used a factor analytical approach to develop a simplified structure of individual preferences, and a standard clustering technique for grouping tourists into preference clusters.

What Makes Tourist Experiences Interesting.

Traditional tourist role theory implies that tourists are novelty seekers familiarity seekers, while the interaction-hypothesis-of-inherent-interest predicts that is maximal when novel familiar elements simultaneously are present in the experience. This paper tests these conflicting theoretical perspectives in three large surveys. In Study 1 ( = 1,029), both novelty and familiarity seeking tourists were asked about how interesting it would be for them to meet tourists from their home country (familiar) or from a foreign country (unfamiliar), either at home (familiar) or abroad (unfamiliar).

Using Elementary Schools for Pediatric Practicum: An Alternative Approach.

Securing clinical sites that facilitate achievement of nursing skills to competently care for children is often challenging for nursing faculty. An additional challenge is helping nursing students learn the importance of conceptually driven practice and its application in the delivery of high quality care. This manuscript describes an alternative pedagogical approach that utilizes elementary schools for pediatric practicum, which is framed by the Whole School, Whole Community, Whole Child Model.

Central role of IPR2-mediated Ca oscillation in self-renewal of liver cancer stem cells elucidated by high-signal ER sensor.

Ca oscillation is a system-level property of the cellular Ca-handling machinery and encodes diverse physiological and pathological signals. The present study tests the hypothesis that Ca oscillations play a vital role in maintaining the stemness of liver cancer stem cells (CSCs), which are postulated to be responsible for cancer initiation and progression. We found that niche factor-stimulated Ca oscillation is a signature feature of CSC-enriched Hep-12 cells and purified α2δ1 CSC fractions from hepatocellular carcinoma cell lines.