Publications by authors named "Dora Pascual"
Article Synopsis
- Loss of proper regulation of NF-κB is linked to chronic inflammatory disorders like rheumatoid arthritis (RA), and the gene ASCC1 plays a crucial role by inhibiting NF-κB target genes.
- A specific truncated variant of ASCC1 found in RA patients reduces its ability to inhibit NF-κB activation and related inflammatory responses.
- Patients with this truncated variant tend to require more aggressive treatments and have lower remission rates, suggesting ASCC1's variant could help in monitoring RA progression and treatment effectiveness.
Objective: To identify factors present in recent onset arthritis that may help to predict rheumatoid arthritis (RA), and to describe a cohort of recent onset RA.
Patients And Method: A 5 year prospective cohort of patients with early oligo and polyarthritis (< 1 year of evolution) from 34 rheumatology units, was studied. Sociodemographic, clinical features and RA risk factors were recorded.
The macrophage inhibitory factor (MIF) is a cytokine that has been implicated in several inflammatory and autoimmune diseases, including rheumatoid arthritis, systemic lupus, glomerulonephritis, and multiple sclerosis. In rheumatoid arthritis (RA), results ranging from lack of association of MIF polymorphisms with RA, to involvement in either severity or susceptibility to the disease have been reported in the past. We aimed at investigating the role of this gene in RA in the Spanish population.
View Article and Find Full Text PDF