Analyzing Photoactivation with Diffusion Models to Study Transport in the Endoplasmic Reticulum Network.

Photoactivation is a paradigm consisting in local molecular fluorescent activation by laser illumination in a chosen region (source) while measuring the concentration at a target region. Data-driven modeling is concerned with the following questions: how from the measurement in these two regions is it possible to infer the properties of molecular propagation? How is it possible to use such responses to infer motions occurring in networks such as the endoplasmic reticulum? In this book chapter, we shall review the data-driven analysis based on diffusion-transport models and numerical simulations to interpret the photoactivation dynamics and extract biophysical parameters. We will discuss modeling approaches to reconstruct local network properties from photoactivation transients.

Who has a problem with chemsex? Identity as a missing link in support services for men who engage in problematic use of psychoactive substances for sexual purposes.

As the social consent for seeking help in the area of psychosexual health increases, specialists observe the current socio-cultural changes and the new phenomena they give rise to be reflected in their patients. One of these relatively new phenomena is chemsex. It is a distinct form of combining highly specific psychoactive substances and sexual activity, practised almost exclusively by men.

Cardiac calcium regulation in human induced pluripotent stem cell cardiomyocytes: Implications for disease modeling and maturation.

Human induced pluripotent stem cell cardiomyocytes (hiPSC-CMs) are based on ground-breaking technology that has significantly impacted cardiovascular research. They provide a renewable source of human cardiomyocytes for a variety of applications including disease modeling and drug toxicity testing. Cardiac calcium regulation plays a critical role in the cardiomyocyte and is often dysregulated in cardiovascular disease.

Logistics of temporary testing centers for coronavirus disease.

The ongoing COVID-19 pandemic has caused the death of millions of people, and PCR testing is widely used as the gold standard method to detect the infections to restrict the outbreak. Through the interviews conducted with people from the field in South Korea, the UK, and Turkey, we have found that there are numerous testing strategies worldwide. Those testing strategies include drive-through and home delivery testing capabilities, local test sites, and mobile test centers.

Artificial intelligence and blockchain implementation in supply chains: a pathway to sustainability and data monetisation?

Digitalisation is expected to transform end-to-end supply chain operations by leveraging the technical capabilities of advanced technology applications. Notwithstanding the operations-wise merits associated with the implementation of digital technologies, individually, their combined effect has been overlooked owing to limited real-world evidence. In this regard, this research explores the joint implementation of Artificial Intelligence (AI) and Blockchain Technology (BCT) in supply chains for extending operations performance boundaries and fostering sustainable development and data monetisation.

Adaptive Single-Channel EEG Artifact Removal With Applications to Clinical Monitoring.

Electroencephalography (EEG) has become very common in clinical practice due to its relatively low cost, ease of installation, non-invasiveness, and good temporal resolution. Portable EEG devices are increasingly popular in clinical monitoring applications such as sleep scoring or anesthesia monitoring. In these situations, for reasons of speed and simplicity only few electrodes are used and contamination of the EEG signal by artifacts is inevitable.

Recommendations of the Polish Sexological Society on medical care in transgender adults - position statement of the expert panel.

Attempts at unifying the diagnostic and therapeutic procedures for transgender individuals experiencing gender dysphoria were first undertaken in Poland in the 1980s. Since then, there has been a change in the perception of transgenderism, almost paradigmatic, expressed in subsequent editions of the diagnostic systems (DSM, ICD), which is also associated with the fundamental changes in the principles of conducting trans-specific healthcare. This triggered the need to formulate recommendations for specialists practicing in Poland, which would at least partly reflect the evolution of views and guidelines on clinical care in transgender adults seeking help due to gender dysphoria.

Tailoring of thermoluminescent properties and assessment of trapping parameters of natural fluorite samples from Dogargaon fluorite mines, India.

Mineral fluorite or fluorspar (CaF ) can host significant quantities of trivalent REE (rare earth element) by substitution with divalent Ca . The fluorites associated with carbonatites are often REE-rich compared to those derived from sedimentary, hydrothermal, or Mississippi Valley-type (MVT) fluorites. The naturally occurring fluorites have several industrial applications one of which is for luminescence.

Gender dysphoria, gender incongruence and gender nonconformity in adolescence - changes and challenges in diagnosis.

Psychiatrists, psychotherapists and sexologists specialising in therapy and support of teenage patients have noticed a significant rise in reports of lack of acceptance of the gender assigned at birth, questioning it, rejecting it, and various ways of experiencing it. Although the history of work with transgender adults goes back to the 1920s, gender dysphoria in adolescents remains a complex phenomenon, and any attempts at standardisation of approaches and protocols have so far been unsuccessful. The controversies associated with the issue often result in hasty conclusions and the false - according to the authors of the present paper - assumption that the population of adolescents who experience gender dysphoria or gender incongruence is homogenous.

Quercetin Attenuates Brain Oxidative Alterations Induced by Iron Oxide Nanoparticles in Rats.

Iron oxide nanoparticle (IONP) therapy has diverse health benefits but high doses or prolonged therapy might induce oxidative cellular injuries especially in the brain. Therefore, we conducted the current study to investigate the protective role of quercetin supplementation against the oxidative alterations induced in the brains of rats due to IONPs. Forty adult male albino rats were allocated into equal five groups; the control received a normal basal diet, the IONP group was intraperitoneally injected with IONPs of 50 mg/kg body weight (B.

Opportunities, challenges and trade-offs with decreasing avoidable food waste in the UK.

Around 6 million tonnes of edible food are being wasted (post-farm gate) in the UK each year. This fraction of edible wasted food is known as avoidable food waste. In a circular economy food is a valuable resource that must be captured at all stages of the food supply chain and, where possible, redistributed for consumption.

Investigation of thermoluminescence response and trapping parameters of natural barite samples from Dongargaon mine, India.

Dosimetry is a technique that quantitatively measures the ionizing radiation absorbed by matter. The present study was conducted on the barites from a mine at Dongargaon in Central India. Morphological and structural analysis of proposed sample was carried out using X-ray diffraction and standard error of the mean.

Labeling Nutrition-Sensitive Food Chains: A Consumer Preference Analysis of Milk Products.

While nutrition-sensitive value-chain approaches are strongly advocated, studies on consumer preferences for such interventions are lacking. This study aims to fill this gap by examining a nutrition-sensitive chain labeling scheme, using the Ugandan dairy sector as a case. A survey was conducted among 250 consumers, primarily eliciting perceptions of the importance of a nutrition-sensitive chain label compared to nutrition claims/facts.

Active flow network generates molecular transport by packets: case of the endoplasmic reticulum.

Biological networks are characterized by their connectivity and topology but also by their ability to transport materials. In the case of random transportation, the efficacy is measured by the time it takes to travel between two nodes of the network. We study here the consequences of a unidirectional transport mechanism occurring in the endoplasmic reticulum (ER) network, a structure present in the cell cytoplasm.

How to transition to reduced-meat diets that benefit people and the planet.

Overwhelming evidence shows that overconsumption of meat is bad for human and environmental health and that moving towards a more plant-based diet is more sustainable. For instance, replacing beef with beans in the US could free up 42% of US cropland and reduce greenhouse gas emissions by 334 mmt, accomplishing 75% of the 2020 carbon reduction target. We summarise the evidence on how overconsumption of meat affects social, environmental and economic sustainability.

DSM-5 paraphilic disorders criteria in the light of autoerotic asphyxiophilia and non-sexual form of oxygen restriction.

The fifth edition of the Diagnostic and Statistical Manual of Mental Disorders published in 2013 has proved to be particularly interesting in the field of sexuality. It introduced a number of significant changes in the definition of sexual norms, among them a widely discussed distinction between paraphilias and paraphilic disorders. The key criterion separating the abnormal sexual interests from the disordered ones is clinically significant distress resulting directly from sexual behavior and/or the risk of suffering or harm to another person as a result of one's sexual behavior.

The character of sexual function of women who have sex with women.

This paper will discuss the character of sexual relationships between women, considering their social and cultural context. The problem is still little known also to experts dealing with mental and sexual health. This may have serious consequences for the process of correct diagnosis of sexuality-related issues reported by those women.

Polyphenols from Wine Lees as a Novel Functional Bioactive Compound in the Protection Against Oxidative Stress and Hyperlipidaemia.

The study examines the potential of wine industry by-product, the lees, as a rich mixture of natural polyphenols, and its physiological potential to reduce postprandial metabolic and oxidative stress caused by a cholesterol-rich diet in model. Chemical analysis of wine lees showed that their total solid content was 94.2%.

Applying Value Stream Mapping to reduce food losses and wastes in supply chains: A systematic review.

The interest to reduce food losses and wastes has grown considerably in order to guarantee adequate food for the fast growing population. A systematic review was used to show the potential of Value Stream Mapping (VSM) not only to identify and reduce food losses and wastes, but also as a way to establish links with nutrient retention in supply chains. The review compiled literature from 24 studies that applied VSM in the agri-food industry.

Beckwith-Wiedemann syndrome and bilateral adrenal pheochromocytoma: sonography and MRI findings.

Beckwith-Wiedemann syndrome is characterized by a group of clinical abnormalities, the most frequent of which are omphalocele, macroglossia, gigantism, neonatal hypoglycemia and umbilical hernia. The association of this syndrome with malignant tumors is well documented. We report a child with this syndrome associated with bilateral adrenal pheochromocytoma.

Color Doppler sonography of normal and torsed testicular appendages in children.

Objective: The purpose of our study was to determine the size and appearance of normal and torsed testicular appendages on color Doppler sonography.

Subjects And Methods: Thirty-three patients with acute scrotal pain underwent gray-scale and color Doppler sonography and subsequent surgery. Twenty-two patients had torsion of the appendix testis, six had epididymitis, three had torsion of the testis, and two had torsion of the appendix epididymidis.

Omental infarction in children: color Doppler sonography correlated with surgery and pathology findings.

Objective: The objective of our report is to describe color Doppler sonography findings of omental infarction and correlate them with surgical and pathology findings. Ten children underwent preoperative gray-scale and color Doppler sonographic examinations; omental infarction was confirmed at surgery.

Conclusion: Color Doppler sonography findings were reviewed and correlated with surgical and pathology findings.

The burden of diabetes and impaired glucose tolerance in India using the WHO 1999 criteria: prevalence of diabetes in India study (PODIS).

This random multistage cross-sectional population survey was undertaken to determine the prevalence of diabetes mellitus (DM) and impaired glucose tolerance (IGT) in subjects aged 25 years and above in India. The study was carried out in 77 centers (40 urban and 37 rural). 18363 (9008 males and 9355 females) subjects were studied.