Publications by authors named "Dor Simkin"
Article Synopsis
- Gliomas consist of malignant cells that exhibit various cellular states, which are organized in distinct ways within the tumor.
- Research reveals three key modes of organization: localized environments with predominant cellular states, specific pairings of these states residing close to one another, and a global architecture consisting of five layers driven by hypoxia.
- The study emphasizes that hypoxia influences the spatial arrangement of these cellular states, while regions far from hypoxic areas show less organization, offering a novel framework for understanding glioma structure.
Article Synopsis
- * Researchers integrated data from 77 studies, evaluating 1,163 tumor samples across 24 types, and identified 41 consensus meta-programs representing distinct gene expression patterns related to ITH.
- * The findings suggest that many of these meta-programs in cancer cells mirror those in non-malignant cells, indicating that some variations in ITH exist even before cancer develops, and the comprehensive dataset is now available for further research on the Curated Cancer Cell Atlas website.
Metastases are often the direct cause of death from pancreatic ductal adenocarcinoma (PDAC). The role of genomic alterations (GA) in mediating tropism and metastasis formation by PDAC cells is currently unknown. We aimed to identify GAs predisposing colonization of PDAC cells to the liver and decipher mechanisms enabling this process.
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