Publications by authors named "Doozie Russell"
Article Synopsis
- The study aimed to evaluate whether increasing urate levels through inosine treatment can slow down the progression of early Parkinson's disease, using data that suggests urate elevation might be beneficial.* -
- Conducted as a phase 3 trial, 298 participants with early-stage Parkinson's disease were randomly assigned to receive either inosine to elevate serum urate levels or a placebo, over a period of up to 2 years.* -
- Results from the study indicated no significant differences in clinical progression rates between the inosine and placebo groups, leading to an early closure of the trial based on an interim analysis.*
Current diagnosis and monitoring of sports-related concussion rely on clinical signs and symptoms, and balance, vestibular, and neuropsychological examinations. Conventional brain imaging often does not reveal abnormalities. We sought to assess if the longitudinal change of functional and structural connectivity of the default-mode network (DMN) can serve as a potential biomarker.
View Article and Find Full Text PDFArticle Synopsis
- This study examined the potential of using inosine, a urate precursor, to safely elevate serum urate levels in early Parkinson’s disease (PD) as a way to potentially slow down the progression of disability associated with the disease.
- Conducted from 2009 to 2011, the SURE-PD trial involved 75 participants who were either given inosine or a placebo in a controlled environment, with a focus on monitoring safety, tolerability, and urate elevation over a median follow-up of 18 months.
- Results showed that serious adverse events were either similar or lower in the inosine groups compared to placebo, with high tolerability reported; however, 3 participants experienced