Hand function is already reduced before RA development and reflects subclinical tenosynovitis.

Background: Clinically suspect arthralgia (CSA) is characterised by arthralgia of small joints and considered a risk stage for development of rheumatoid arthritis (RA). However, it remains unknown if the function of the hands is already affected and what mechanisms underlie impaired hand-function in CSA.

Methods: We studied various measures of hand function in two CSA populations.