Publications by authors named "Doongro Mal"
Article Synopsis
- * Common ocular signs of TS include achromic patches and small retinal tumors (less than 5 mm), and the condition is diagnosed through a combination of clinical features and genetic tests.
- * A case of a 15-year-old girl with seizures and blurred vision was diagnosed with TS after imaging revealed brain and lung abnormalities, emphasizing the need for early diagnosis and management to prevent complications.
The chimeric antigen receptor (CAR) design, first invented by Zelig Eshhar, paved the way for the use of genetically modified T-cells in targeted therapy against cancer cells. Since then, it has gone through many generations, especially with the integration of co-stimulation in the second and third-generation CARs. However, it also mounts a hyperactive immune response named as cytokine release syndrome with the release of several cytokines eventually resulting in multiple end-organ toxicities.
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