Taper versus discontinuation of tocilizumab in patients with giant cell arteritis: Real-world experience from a tertiary center.

Introduction: Following the approval of tocilizumab (TCZ) for giant cell arteritis (GCA), recent studies have shown a high relapse frequency after abrupt discontinuation of TCZ. However, a thorough exploration of TCZ tapering compared to abrupt discontinuation has never been undertaken. Likewise, adverse events have only been scarcely investigated in routine care.

An international survey of current management practices for polymyalgia rheumatica by general practitioners and rheumatologists.

Objectives: To explore current management practices for PMR by general practitioners (GPs) and rheumatologists including implications for clinical trial recruitment.

Methods: An English language questionnaire was constructed by a working group of rheumatologists and GPs from six countries. The questionnaire focused on: 1: Respondent characteristics; 2: Referral practices; 3: Treatment with glucocorticoids; 4: Diagnostics; 5: Comorbidities; and 6: Barriers to research.

Normative Reference of the Single Leg, Medial Countermovement Jump in Adolescent Youth Ice Hockey Players.

Functional performance tests provide quantitative information on specialized sport movements and are important for documenting training and fatigue. The single leg, medial countermovement jump provides objective measures of frontal plane force, velocity and power, and is relevant for ice hockey players given the similar lateral movement to ice skating. This study measured normative single leg, medial countermovement jump parameters (i.

Reliability of the Single-Leg, Medial Countermovement Jump in Youth Ice Hockey Players.

Appropriate performance tests are critical for documenting training, fatigue and injury-related changes. Functional performance testing can provide quantitative information on specialized sport movements. The single-leg, medial countermovement jump is an objective measure of frontal plane force, velocity and power, and is particularly applicable for ice hockey players given that ice skating involves applying lateral forces.

Overactive bladder in patients with myasthenia gravis-A cross-sectional population-based study.

Background: In myasthenia gravis (MG), first-line treatment for MG is acetylcholinesterase inhibitors which alleviates symptoms, but concomitantly may cause autonomic adverse effects.

Aims Of The Study: In this study, we evaluated if symptoms of overactive bladder (OAB) are more frequent among MG patients than healthy controls.

Methods: Eighty-three MG patients and 50 healthy sex- and age-matched controls were included and answered the questionnaire "International Consultation on Incontinence Questionnaire Overactive Bladder Module" (ICIQ-OAB), including questions about polyuria, nocturia, urgency, and stress incontinence.

[Neuroendocrine paranasal tumour with symptoms from tooth in upper jaw].

In Denmark, the annual incidence of paranasal malignancies is approximately 60, often presenting with symptoms from growth into neighbouring structures. This case report is of a primary neuroendocrine paranasal tumour with distant metastases in an 81-year-old woman. Following a tooth extraction, the patient developed left side proptosis.

What Is Injury in Ice Hockey: An Integrative Literature Review on Injury Rates, Injury Definition, and Athlete Exposure in Men's Elite Ice Hockey.

Injuries in men's elite ice hockey have been studied over the past 40 years, however, there is a lack of consensus on definitions of both injury and athlete exposure. These inconsistencies compromise the reliability and comparability of the research. While many individual studies report injury rates in ice hockey, we are not aware of any literature reviews that have evaluated the definitions of injury and athlete exposure in men's elite ice hockey.

[High Serum Concentrations of Uric Acid: Clinical and Prognostic Significance in Chronic Heart Failure].

The article is devoted to the value of asymptomatic hyperuricemia in patients with chronic heart failure (CHF). The review summarizes results of a number of epidemiological reports that have increasingly linked elevated serum uric acid with an increased risk of incident CHF and adverse outcomes in CHF patients. Pharmacological and non-pharmacological approaches to influencing disturbances of uric acid metabolism are discussed.

[Hyperuricemia and cardiovascular continuum].

Many recent reports suggest the relationship between hyperuricemia, risk and prognosis of arterial hypertension and coronary heart disease. The works on the clinical and prognostic significance in chronic heart failure are few even if this pathology deteriorates prognosis of some cardiovascular diseases. Hyperuricemia is considered to be a component of cardiovascular continuum, risk factor of chronic heart failure and marker of its unfavourable outcome.

[Experimental morphological basis of the application of microsurgical intestinal suture under the conditions of inflammatory pathology of gastro-intestinal tract organs].

Experimental study of morphological peculiarities of intestinal wall and common bile duct wall healing using microsurgical sutures under the condition of peritonitis and cholangitis, was performed in 112 dogs. It was shown that the microsurgical suturing of intestinal wall and common bile duct wall affected by the inflammatory process, created the favorable conditions for wound healing. During the recovery period, the thickness of all the layers of the intestinal wall decreased, the disturbances of the normal fibrous structure and the vascular reaction of the submucosa were reduced.

[Clinical implication of the body mass and waist/thigh indices in hypertensive patients: correlations with blood uric acid levels].

Body mass index (BMI) and waist/thigh circumference (WTC) were estimated in 104 patients with mild and moderate arterial hypertension (AH) lasting for 8.4 +/- 3.2 years (63 men, 41 women, mean age 50.

[Relationship between mass of the left ventricular myocardium and uric acid metabolic imbalance in patients with arterial hypertension].

Aim: To analyse relationships between left ventricular myocardium mass (LVMM) and imbalance of uric acid metabolism in patients with arterial hypertension (AH).

Material And Methods: Body mass index, waist/hip circumference index, levels of uric acid in the blood and urine, urinary excretion of albumin, LVMM were estimated in 106 patients with mild and moderate AH (70 males and 36 females, mean age 51 +/- 8.5 years).

[Urate affection of kidneys and metabolic disturbances in hypertensive patients].

Aim: To detect urate renal affection and correlations between purine metabolism, hyperinsulinemia, obesity, dyslipidemia in patients with arterial hypertension (AH).

Materials And Methods: 78 patients with mild, moderate and severe hypertension have undergone 24-h monitoring of arterial pressure and microalbuminuria test.

Results: Hyperuricemia was diagnosed in 21 of 78, hyperuricosuria in 27 patients.

[Physiologic reactions to electric stimulation of the labyrinth].

Physiological responses to electric stimulation of the skin projections of labyrinths on the outer ear were investigated. The experiments were carried out on 56 test subjects using electric current in the range of 20 microA to 1.5 mA with the frequency 0.

[Automated system for research on intragastric pH measurement].

An automated system for the study of the intragastric PH-metry on the basis of the Electronika KI-20 microcomputer has been considered. The paper gives a brief description of the apparatus, program and the operator's work with the system.