Publications by authors named "Donraporn Daranarong"
Ethyl cellulose (EC), a degradable cellulose derivative, served as a primary component in membranes fabricated by electrospinning for in vitro drug delivery applications. An effective strategy to enhance drug release was incorporating high-surface-area nanomaterials into polymeric drug carriers, which facilitated drug attachment to both the polymer matrix and additive surfaces, promoting release. MXene (TiCT) demonstrated promising potential in improving tensile mechanical properties, antibacterial activity, and curcumin (Cur) release performance of EC membrane.
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- * The composite films made with BC, MoS, and HCNTs show significant improvements in strength and elasticity—up to 148% and 333% increases—thanks to the combined effects of the additives.
- * Testing reveals these composite films are biocompatible, supporting cell viability over 70%, and they are effective at absorbing and releasing antibiotics to fight bacterial growth, indicating their potential as antibiotic carriers.
With the increasing water consumption, water evaporators have been investigated for clean water production. Herein, the fabrication of electrospun composite membrane evaporators based on ethyl cellulose (EC), with the incorporation of light-absorption enhancers 2D MoS and helical carbon nanotubes, for steam generation and solar desalination is described. Under natural sunlight, the maximum water evaporation rate was 2.
View Article and Find Full Text PDFThe wound-healing process can be disrupted at any stage due to various internal and external factors. The inflammatory stage of the process plays a vital role in determining the outcome of the wound. Prolonged inflammation due to bacterial infection can lead to tissue damage, slow healing, and complications.
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- Plastic waste contributes significantly to climate change; biodegradable films made from polymers like carboxymethyl cellulose (CMC) are being developed as a solution.
- A new method has been introduced to enhance the strength and barrier properties of CMC/poly(vinyl alcohol) (PVA) films for packaging nonfood dried items by incorporating buckypapers with various carbon nanotubes.
- The resulting polymer composite films show increased tensile strength, Young's modulus, and toughness, as well as improved barrier performance against water vapor, while also demonstrating higher thermal stability.
Rapid release and diminished stability are two of the limitations associated with the growth factors that are essentially used in dental applications. These growth factors are employed to enhance the quality and quantity of tissue or bone matter during regeneration. Therefore, drug delivery devices and systems have been developed to address these limitations.
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- Nerve guide conduits (NGCs) for repairing peripheral nerve injuries are currently not efficient enough to replace autografts, leading to the development of advanced 3D electrospun scaffolds made from PLCL and PLGA.
- These scaffolds have been enhanced with polypyrrole (PPy), improving their biocompatibility, hydrophilicity, and conductivity, making them suitable for supporting nerve regeneration.
- Overall, the study indicates that the new 3D/E/PPy scaffolds exhibit better cell compatibility and lower tissue damage, showcasing potential for future use in peripheral nerve repair.
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- A medical-grade poly(l-lactide--ε-caprolactone) (PLC) copolymer was created for surgical sutures, using a new tin(II) -butoxide initiator and a specific ratio of monomers to enhance absorbability.
- The fibers were manufactured through a process that included melt extrusion and heat treatment to improve their mechanical strength, achieving tensile strength similar to commercial products.
- The fibers were coated with levofloxacin for healing, showing effective controlled drug release over 30 days, strong antimicrobial properties against bacteria like MRSA, and were found to be nontoxic in cytotoxicity tests.
Stem cells based tissue engineering requires biocompatible materials, which allow the cells to adhere, expand, and differentiate in a large scale. An ideal biomaterial for clinical application should be free from mammalian products which cause immune reactivities and pathogen infections. We invented a novel biodegradable poly(L-lactic-co-ε-caprolactone)-sericin (PLCL-SC) copolymer membrane which was fabricated by electrospinning.
View Article and Find Full Text PDFElectrospinning can produce nanofibrous scaffolds that mimic the architecture of the extracellular matrix and support cell attachment for tissue engineering applications. In this study, fibrous membranes of polyhydroxybutyrate (PHB) with various loadings of poly(L-lactide-co-ε-caprolactone) (PLCL) were successfully prepared by electrospinning. In comparison to PLCL scaffolds, PLCL blends with PHB exhibited more irregular fibre diameter distributions and higher average fibre diameters but there were no significant differences in pore size.
View Article and Find Full Text PDFIn this study, for the first time, a biodegradable poly(L-lactide-co-ε-caprolactone), PLC 67:33 copolymer was developed for use as temporary scaffolds in reconstructive nerve surgery. The effect of the surface topology and pore architecture were studied on the biocompatibility for supporting the growth of human umbilical cord Wharton's jelly-derived mesenchymal stem cells (hWJ-MSCs) and human neuroblastoma cells (hNBCs) as cell models. Porous PLC membranes were prepared by electrospinning and phase immersion precipitation with particulate leaching and nonporous PLC membranes were prepared by solvent casting.
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