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Publications by authors named "Donnchadh S Dunican"

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Synopsis of recent research by authors named "Donnchadh S Dunican"

  • Donnchadh S Dunican's research focuses on the relationship between histone modifications and DNA methylation in the context of cancer, specifically exploring bivalent promoters in embryonic stem cells and their relevance to hypermethylation in cancer.
  • One key finding suggests that bivalent promoters, marked by both repressive H3K27me3 and activating H3K4me3 modifications, demonstrate a complex sensitivity to changes in DNA methylation levels, impacting their roles in oncogenesis.
  • The study highlights that only a subset of bivalent genes are prone to hypermethylation in cancer, indicating that different bivalent promoters may exhibit varying responses to alterations in the H3K4me3 and H3K27me3 ratio.

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