Unified Multifactorial Model of Parental Factors in Community-Based Pediatric Chronic Pain.

Objective: The combination of parental chronic pain and internalizing characteristics are relevant to chronic pain experiences in their children. A promising unified multifactorial intergenerational model of chronic pain was published in 2019; however, this model was only generalizable to children with severe chronic pain and some factors had limitations. This study aimed to determine validity of an adapted multifactorial model, including parent and child chronic pain status, pain characteristics, pain-related functioning, and internalizing symptoms, in a community setting.

The Val66Met Polymorphism Modulates Resilience of Neurological Functioning to Brain Ageing and Dementia: A Narrative Review.

Brain-derived neurotropic factor (BDNF) is an abundant and multi-function neurotrophin in the brain. It is released following neuronal activity and is believed to be particularly important in strengthening neural networks. A common variation in the gene, a valine to methionine substitution at codon 66 (Val66Met), has been linked to differential expression of BDNF associated with experience-dependent plasticity.

RedUSe: reducing antipsychotic and benzodiazepine prescribing in residential aged care facilities.

Objective: To assess the impact of a multi-strategic, interdisciplinary intervention on antipsychotic and benzodiazepine prescribing in residential aged care facilities (RACFs). Design, setting: Prospective, longitudinal intervention in Australian RACFs, April 2014 - March 2016.

Participants: 150 RACFs (with 12 157 residents) comprised the main participant group; two further groups were consultant pharmacists (staff education) and community pharmacies (prescribing data).

Sleep and agitation in nursing home residents with and without dementia.

Background: The prevalence of dementia in Australian nursing homes is high. A large proportion of residents express themselves through agitated behaviors, with substantial interpersonal and day-to-day variance. One factor that may increase agitation is poor sleep.

Do older individuals have difficulty processing motion or excluding noise? Implications for safe driving.

This study aimed to determine if difficulties extracting signal from noise explained poorer coherent motion thresholds in older individuals, particularly women. In four experimental conditions the contrast of the signal and noise dots used in a random dot kinematogram was manipulated. Coherence thresholds were highest when the signal dots were of a lower contrast than the noise dots and lowest when the signal dots were of a higher contrast than the noise dots.