Combination of Clozapine With Long-Acting Injectable Antipsychotics in Treatment-Resistant Schizophrenia: Preliminary Evidence From Health Care Utilization Indices.

Background: Clozapine is indicated for treatment-resistant schizophrenia (TRS), but only 30%-60% of patients will respond. There have been studies of clozapine augmentation with oral second-generation antipsychotics with mixed results, but no studies considering the combination with long-acting injectable antipsychotics (LAIAs). This study is the first to attempt to establish the benefits of the combination of clozapine and LAIAs in TRS using a variety of outcome measures of symptomatology and quality of life.

An empirical investigation into the effectiveness of genetic genealogy to identify individuals in the UK.

The use of genetic genealogy techniques to identify Joseph James DeAngelo as the prime suspect in the Golden State Killer case in 2018 has opened up a new approach to investigation of cold cases. Since that breakthrough, genetic genealogy methods have been reported to be applied to around 100 cases. To date, all of these reports relate to investigations in the US, where the high uptake of "direct-to-consumer" (DTC) genetic testing by individuals conducting private ancestral research has provided the necessary publicly available data for successful forensic investigations.

Quality of life in young people: ratings and factor structure of the Quality of Life Profile-Adolescent Version.

The purpose of the study was to provide British data relating to the 54-item Quality of Life Profile Adolescent Version (QOLPAV; Raphael et al., 1996, Journal of Adolescent Health, 19, 366-375) and to explore the underlying factor structure of the questionnaire. The relationship between demographic variables (such as social economic status, gender and ethnicity) and quality of life (QOL) were investigated.