Publications by authors named "Donna M Hutchison"
Purpose: To determine whether more severe baseline damage impedes measurement of minimum rim width (MRW) and peripapillary retinal nerve fiber layer thickness (RNFLT) change in glaucoma patients because of a floor effect.
Design: Prospective, longitudinal cohort study in a hospital-based setting.
Participants: The study included patients with open-angle glaucoma and healthy control subjects.
Importance: Estimating the rate of glaucomatous visual field change provides practical assessment of disease progression and has implications for management decisions.
Objective: To assess the rates of visual field change in patients receiving treatment for glaucoma compared with healthy individuals over an extensive follow-up period and to quantify the impact of important covariates for these rates.
Design, Setting, And Participants: This prospective longitudinal cohort study was conducted in a hospital-based setting from January 1991 to February 2020.
Purpose: To determine the impact of glaucoma severity on rates of change of minimum rim width (MRW), peripapillary retinal nerve fiber layer (RNFL), and macular ganglion cell layer (GCL) thickness.
Design: Prospective, cohort study.
Methods: Glaucoma patients and healthy subjects had optical coherence tomography scans at 6-month intervals.
Purpose: To determine whether the 10-2 test of the Humphrey Field Analyzer detected a higher proportion of abnormal visual fields compared with the 24-2 test in the central 10° of patients with early glaucomatous visual field damage.
Design: Prospective observational study.
Participants: Patients with open-angle glaucoma and healthy control participants.
Background/aims: Quantitative analysis of optical coherence tomography angiography (OCT-A) images requires a reproducible approach that accounts for sectoral loss. The objective of this study was to determine whether an index that accounts for both global (perfusion density, PD) and asymmetric loss of perfusion, rather than PD alone, more reliably measures loss of perfusion in patients with glaucoma.
Methods: We analysed macular OCT-A scans of 95 glaucoma patients and 59 control subjects.
Purpose: To determine whether the glaucoma diagnostic accuracy of age- and Bruch membrane opening area (BMOA)-adjusted normative classifications of minimum rim width (MRW) and retinal nerve fiber layer thickness (RNFLT) is dependent on BMOA, in a European descent population.
Design: Retrospective, cross-sectional study.
Methods: We included 182 glaucoma patients and 166 healthy controls for the primary study, and 105 glaucoma patients in a second sample used for a replication study.
Background/aims: Optical coherence tomography (OCT) imaging of the optic nerve head minimum rim width (MRW) has recently been shown to sometimes contain components besides extended retinal nerve fibre layer (RNFL). This study was conducted to determine whether excluding these components, termed protruded retinal layers (PRLs), from MRW increases diagnostic accuracy for detecting glaucoma.
Methods: In this cross-sectional study, we included 123 patients with glaucoma and 123 normal age-similar controls with OCT imaging of the optic nerve head (24 radial scans) and RNFL (circle scan).
Background/aims: To determine the effect of glaucoma on outer retinal layer thickness in eyes with horizontal hemifield visual field (VF) defects.
Methods: We conducted a cross-sectional study in glaucomatous eyes with repeatable (in three or examinations) horizontal hemifield VF (programme 24-2) defect defined as: all five nasal VF locations immediately either above or below the horizontal midline abnormal in the pattern deviation plot with p<0.5%; no mirror-image adjacent 5 VF locations abnormal in the pattern deviation plot and no non-edge VF locations in the non-affected hemifield abnormal in the pattern deviation plot with p<1%.
Purpose: To compare the visibility of deep optic nerve head (ONH) structures and the visible area of the anterior surface of the lamina cribrosa (ASLC) with spectral-domain optical coherence tomography (SD-OCT) and swept-source OCT (SS-OCT).
Materials And Methods: In total, 33 glaucoma patients were imaged with SD-OCT (Spectralis, 24 radial B-scans centered on the ONH) and SS-OCT (Atlantis, 12 radial and a horizontal and vertical raster scan pattern containing 5 lines each, centered on the ONH). One of the SS-OCT horizontal and vertical scans that was best matching with the horizontal and vertical scan lines with those of SD-OCT was selected.
Purpose: To determine whether: (1) change in lamina cribrosa depth occurs more frequently than change in neuroretinal parameters in glaucoma, and (2) Bruch's membrane or anterior sclera should be used as a reference plane when measuring laminar depth.
Design: Prospective observational study.
Participants: One hundred fifty-five glaucoma patients and 35 healthy controls.
Purpose: To determine whether structural abnormalities of the lamina cribrosa explain the presence of optic disc hemorrhages, we determined the spatial concordance between disc hemorrhages and laminar disinsertions from the sclera.
Design: Prospective noninterventional study.
Participants: From open-angle glaucoma patients followed up prospectively, we identified 52 eyes of 46 open-angle glaucoma patients with optic disc hemorrhage (ODH+ group) in at least 1 optic disc photograph during follow-up.
Purpose: To compare the diagnostic accuracy of conventional sector-based analysis with a method devised to detect the smallest localized neuroretinal rim and retinal nerve fiber layer thickness (RNFLT) damage.
Methods: One eye of 151 glaucoma patients and 83 healthy controls (median age and MD, 71.7 and 66.
Purpose: To describe longitudinal rates of change of neuroretinal parameters in patients with glaucoma and healthy controls, and to evaluate the influence of covariates.
Design: Prospective longitudinal study.
Participants: Treated patients with glaucoma (n = 192) and healthy controls (n = 37).
Purpose: To evaluate the structure-function relationship between disc margin-based rim area (DM-RA) obtained with confocal scanning laser tomography (CSLT), Bruch's membrane opening-based horizontal rim width (BMO-HRW), minimum rim width (BMO-MRW), peripapillary retinal nerve fiber layer thickness (RNFLT) obtained with spectral-domain optical coherence tomography (SD-OCT), and visual field sensitivity.
Methods: We examined 151 glaucoma patients with CSLT, SD-OCT, and standard automated perimetry on the same day. Optic nerve head (ONH) and RNFL with SD-OCT were acquired relative to a fixed coordinate system (acquired image frame [AIF]) and to the eye-specific fovea-BMO center (FoBMO) axis.
Automated segmentation of optic nerve head structures with optical coherence tomography.
Invest Ophthalmol Vis Sci
February 2014
Purpose: To quantify and characterize the difference between automated and manual segmentation of optic nerve head structures with spectral-domain optical coherence tomography (SD-OCT).
Methods: Optic nerve head radial scans in 107 glaucoma patients and 48 healthy controls were conducted with SD-OCT. Independent segmentations of the internal limiting membrane (ILM) and Bruch's membrane opening (BMO) were performed manually with custom software and with an automated algorithm in each radial scan.
Importance: A new analysis method called permutation of pointwise linear regression measures the significance of deterioration over time at each visual field location, combines the significance values into an overall statistic, and then determines the likelihood of change in the visual field. Because the outcome is a single P value, individualized to that specific visual field and independent of the scale of the original measurement, the method is well suited for comparing techniques with different stimuli and scales.
Objective: To test the hypothesis that frequency-doubling matrix perimetry (FDT2) is more sensitive than standard automated perimetry (SAP) in identifying visual field progression in glaucoma.
Article Synopsis
- The study critiques the traditional method of assessing the neuroretinal rim using the clinical optic disc margin (DM), highlighting that DM lacks anatomical reliability due to hidden extensions of Bruch's membrane and neglect of rim tissue orientation.
- The researchers introduced the BMO-MRW metric, which represents the true anatomical border of the rim and accounts for the varying orientation of the rim tissue.
- Results showed that BMO-MRW had superior diagnostic capability for open-angle glaucoma compared to conventional parameters, making it a promising tool for better identification of the disease.
Objective: To examine peripapillary choroidal thickness in healthy controls and in patients with glaucoma who have focal, diffuse, and sclerotic optic disc damage.
Methods: Healthy controls (n=92) and patients with glaucoma who have focal (n=34), diffuse (n=35), and sclerotic (n=34) optic disc damage were imaged with spectral-domain optical coherence tomography (12° circular scan protocol centered on optic nerve head). Peripapillary choroidal thickness was measured as the distance between the automatically segmented retinal pigment epithelium/Bruch's membrane and the manually outlined interface between the posterior choroid and the anterior border of the sclera in eyes in which the anterior scleral border was visible over more than 85% of the scan circumference.
Purpose. To compare the properties of the visual field index (VFI) to those of mean deviation (MD) in patients with glaucoma. Methods.
View Article and Find Full Text PDFObjective: To determine the response of the anterior lamina cribrosa and prelaminar tissue to acute elevation of intraocular pressure (IOP) in glaucoma patients and healthy subjects.
Design: Prospective case-control series.
Participants And Controls: Patients with open-angle glaucoma (n = 12; mean age ± standard deviation [SD], 66.
Purpose: To compare confocal scanning laser tomography (CSLT) to optic disc photography for detecting progressive glaucomatous disc changes.
Methods: Four expert observers first examined a training set of 40 pairs of monoscopic disc photographs to help set a criterion for change. They then classified 44 pairs of monoscopic photographs of patients followed prospectively as having either definitely no change, probably no change, probably change, or definitely change (score, 0, 1, 2, or 3, respectively).
Purpose: To compare test results from second-generation Frequency-Doubling Technology perimetry (FDT2, Humphrey Matrix; Carl-Zeiss Meditec, Dublin, CA) and standard automated perimetry (SAP) in patients with glaucoma. Specifically, to examine the relationship between visual field sensitivity and test-retest variability and to compare total and pattern deviation probability maps between both techniques.
Methods: Fifteen patients with glaucoma who had early to moderately advanced visual field loss with SAP (mean MD, -4.
Purpose: To compare frequency-doubling technology (FDT) perimetry with standard automated perimetry (SAP) for detecting glaucomatous visual field progression in a longitudinal prospective study.
Methods: One eye of patients with open-angle glaucoma was tested every 6 months with both FDT and SAP. A minimum of 6 examinations with each perimetric technique was required for inclusion.