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Publications by authors named "Donna M Geddes-Klein"

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Synopsis of recent research by authors named "Donna M Geddes-Klein"

  • Donna M Geddes-Klein's research primarily focuses on the mechanisms of neuronal injury and protective responses, particularly in the context of traumatic brain injury (TBI) and excitotoxicity, exploring the roles of NMDA receptor subunits in mediating signaling pathways and cellular outcomes.
  • Her findings indicate that the specific subunits of NMDA receptors (NR2A and NR2B) differentially influence MAPK signaling and mitochondrial morphology following excitotoxic insults, offering insights into potential pharmacological strategies for treating neurological conditions.
  • Geddes-Klein's work emphasizes the complexity of TBI and suggests that the mechanics of neuronal injury can significantly affect cellular responses, highlighting the importance of model selection in understanding the pathophysiology of brain injuries.

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