Publications by authors named "Donna H Tran"
Sci Transl Med
March 2019
Article Synopsis
- Epstein-Barr virus (EBV) is linked to 1-2% of human cancers, such as various lymphomas and gastric carcinoma, due to its persistent latent infection promoting tumor growth.
- EBNA1, a viral protein present in all EBV-related tumors, is crucial for viral functions and presents a target for developing treatments.
- Researchers have identified specific inhibitors that block EBNA1's DNA binding activity, showing effectiveness in lab models by suppressing tumor growth and altering important signaling pathways in nasopharyngeal carcinoma.
