Publications by authors named "Donna Groschen"
Article Synopsis
- Osteosarcoma is a serious type of bone cancer that mainly affects kids and young adults, and it can be hard to treat with standard methods.
- Researchers tested a new treatment called VSV-IFNβ-NIS on dogs with the same cancer to see if it could help improve survival rates.
- The treatment seemed safe and showed promise, as about 35% of the treated dogs lived longer, and they also had signs of strong immune responses against the cancer.
Article Synopsis
- Osteosarcoma is a serious bone cancer that mostly affects kids, teens, and young adults, and even with treatment, some patients get worse.
- A new treatment using a special virus called VSV-IFNβ-NIS was tested on dogs with this type of cancer before they had surgery, and it showed promising results.
- The treatment was safe, helped some dogs live longer, and boosted their immune systems to fight cancer better.
To determine the symptomatic and disease-modifying capabilities of sEH and COX inhibitors during joint inflammation. Using a blinded, randomized, crossover experimental design, 6 adult healthy horses were injected with lipopolysaccharide (LPS; 3 μg) from in a radiocarpal joint and concurrently received the non-selective cyclooxygenase (COX) inhibitor phenylbutazone (2 mg/kg), the sEH inhibitor -TUCB (1 mg/kg) or both (2 mg/kg phenylbutazone and 0.1, 0.
View Article and Find Full Text PDFObjective: To evaluate the biochemical and biomechanical properties of native and decellularized superficial digital flexor tendons (SDFTs) and deep digital flexor tendons (DDFTs) harvested from the pelvic limbs of orthopedically normal dogs.
Sample: 22 commercially supplied tendon specimens (10 SDFT and 12 DDFT) harvested from the pelvic limbs of 13 canine cadavers.
Procedures: DNA, glycosaminoglycan, collagen, and protein content were measured to biochemically compare native and decellularized SDFT and DDFT specimens.
The aim of this study was to evaluate the effect of three footing surfaces on the flexion/extension, and range of motion (ROM) of the carpus, tarsus and fetlocks in the horse. The percentage of stride spent in the stance phase of sound horses at the walk was also measured. Nine sound horses were walked on hard ground (HD), soft ground (SF) and a land treadmill (LT), and five complete gait cycles were recorded by a digital video camera.
View Article and Find Full Text PDFObjective: To determine the maximum amount of flexion and extension of the carpal, tarsal, metacarpophalangeal, and metatarsophalangeal joints and the percentage duration of the stance and swing phases of the stride for horses walking on an underwater treadmill in various water depths.
Animals: 9 healthy adult horses.
Procedures: Zinc oxide markers were placed on the forelimbs and hind limbs of the horses.