Publications by authors named "Donna Chantler"
Article Synopsis
- Premature cardiovascular disease and graft loss are significant issues for kidney transplant recipients (KTRs), with vascular stiffness and calcification being common markers linked to vitamin K deficiency.
- A clinical trial tested if vitamin K supplementation could reduce these markers in KTRs, randomly assigning participants to either vitamin K or a placebo over one year.
- Results showed no significant difference in vascular stiffness or calcification between the groups, suggesting that improving vascular health in KTRs may need more comprehensive strategies.
Background: Vascular calcification, a risk factor for cardiovascular disease, is common among patients with CKD and is an independent contributor to increased vascular stiffness and vascular risk in this patient group. Vitamin K is a cofactor for proteins involved in prevention of vascular calcification. Whether or not vitamin K supplementation could improve arterial stiffness in patients with CKD is unknown.
View Article and Find Full Text PDFA 16-year-old female with mild hirsutism was noted to have a small, smooth, non-tender goitre. A resting peripheral tremor, but no other symptoms or signs of thyroid dysfunction were present. Her only medication was the contraceptive pill.
View Article and Find Full Text PDFA 65-year-old woman presented to the endocrine clinic with increasing facial hirsutism over the past 6 months. She was noted to have excess hair on forearms, back and abdomen, along with some frontal balding. There were no abnormalities of the external genitalia, blood pressure was satisfactory and weight was stable.
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