Defining the Optimal Treatment Strategy in Patients With Uterine Serous Carcinoma.

Aims: Uterine serous carcinoma (USC) is an aggressive subtype of endometrial cancer with high rates of relapse and death. As adjuvant therapy might be beneficial in early-stage disease, the impact of standard complete surgical staging is questioned. Therefore, we wanted to explore the optimal treatment strategy for women diagnosed with USC.

Uptake and provision of self-care interventions for sexual and reproductive health: findings from a global values and preferences survey.

Self-care interventions hold the potential to improve sexual and reproductive health (SRH) and well-being. Yet key knowledge gaps remain regarding how knowledge and uptake vary across different types of self-care interventions. There is also limited understanding of health workers' confidence in promoting SRH self-care interventions, and how this may differ based on personal uptake experiences.

Systematic Review on Socioeconomic Deprivation and Cervical Cancer: Inequalities in Survival.

Purpose: To evaluate the association between socioeconomic deprivation and survival in cervical cancer.

Methods: A systematic search of Medline (1946-2020), Embase (1980-2020), Cinahl (1981-2020) and the Cochrane Controlled Register of trials was performed. Included were women (age ≥ 18 years) diagnosed with primary cervical cancer.

The impact of socioeconomic deprivation on mortality in cervical cancer patients in Cornwall (England).

Objectives: To assess the association between risk factors, including socioeconomic deprivation, and mortality, recurrence and chemo- or radiation toxicity in cervical cancer patients.

Methods: Retrospective study of cervical cancer patients diagnosed between January 2007 and July 2018. Patient characteristics and mortality data, including recurrence, were assessed, together with socioeconomic deprivation measures evaluated using the English Indices of Multiple Deprivation.

Detection of microRNA in urine to identify patients with endometrial cancer: a feasibility study.

Objective: To find dysregulated urinary microRNAs associated with endometrial cancer as a first step in finding a non-invasive new diagnostic biomarker. The second objective is to determine the correlation of urinary microRNAs with clinicopathological characteristics.

Methods: A prospective cohort study of patients presenting with abnormal bleeding between March and November 2019 was performed at the Royal Cornwall Hospital Trust Truro.

Usefulness of microRNA detection in the diagnostics of endometrial cancer.

Introduction: MicroRNAs (miRNAs) are noncoding RNAs that regulate gene expression and contribute to the development of cancer. They have been shown to be stable in tissue samples and may be promising diagnostic biomarkers for endometrial cancer.

Material And Methods: A retrospective cohort study of women diagnosed with endometrial cancer between January 2017 and December 2017 was performed at the Royal Cornwall Hospital.

The role of sarcopenic obesity in high-grade endometrial cancer.

Objective: To investigate the relationship between obesity and sarcopenia in relation to overall survival (OS) and disease-specific survival (DSS) in high-grade endometrial cancer patients.

Methods: We conducted a retrospective study in women diagnosed with high-grade endometrial cancer (EC) between February 2006 and August 2017 in the Royal Cornwall Hospital who had abdominal computerized tomography (CT)-scan as part of routine staging work-up. Sarcopenia was assessed by measuring psoas-, paraspinal- and abdominal wall muscles on CT and defined by skeletal muscle index ≤41 cm /m .

Obesity and visceral fat: Survival impact in high-grade endometrial cancer.

Background: Obesity is an important risk factor for the development of endometrial cancer (EC). Recent data showed that body fat distribution might be more relevant than Body Mass Index (BMI). High visceral fat percentage was shown to be an independent predictor for survival in EC, but mainly included grade 1-2 EC.

Diagnostic value of microRNA panel in endometrial cancer: A systematic review.

Purpose: We conducted a systematic review to evaluate the overall diagnostic accuracy of miRNAs in detecting endometrial cancer.

Materials And Methods: A systematic search of Medline, Embase, Cinahl and the Cochrane Controlled Register of Trials was performed to identify studies reporting on the diagnostic value of miRNA in EC patients. Included were diagnostic studies looking at miRNA expression in women diagnosed with endometrial cancer.

Management of Malignant Vulval Melanoma: A Retrospective Case Series and Review of the Literature.

Objectives: The aims of the study were to evaluate clinicopathologic features, management, and outcomes in vulval melanoma and to review the literature.

Materials And Methods: Data were collected retrospectively on patients with vulval melanoma from 2001 to 2017 in 5 gynecological oncology cancer centers (Bristol, Taunton, Truro, Plymouth, and Cheltenham). SPSS software was used for univariate and multivariate statistical analysis.

Socioeconomic deprivation and survival in endometrial cancer: The effect of BMI.

Objectives: METHODS: This is a retrospective study of surgically managed endometrial cancer patients in the Royal Cornwall Hospital Truro between January 2006 and August 2017. Patient characteristics, overall survival, recurrence free survival and intra- and postoperative outcomes were evaluated across socioeconomic deprivation groups in which socioeconomic deprivation was measured with the English Indices of Multiple Deprivation (IMD).

Results: In total, we identified 831 women, of which 690 were included.

Integrated Care for Frail Elderly: A Qualitative Study of a Promising Approach in The Netherlands.

Introduction: Increasingly, frail elderly need to live at home for longer, relying on support from informal caregivers and community-based health- and social care professionals. To align care and avoid fragmentation, integrated care programmes are arising. A promising example of such a programme is the Care Chain Frail Elderly (CCFE) in the Netherlands, which supports elderly with case and care complexity living at home with the best possible health and quality of life.

Systematic review on socioeconomic deprivation and survival in endometrial cancer.

Purpose: The primary objectives in this review were to (1) assess the association between socioeconomic deprivation and survival in endometrial cancer patients (2) investigate if there is an association between socioeconomic deprivation and peri-operative morbidity in endometrial cancer patients.

Methods: We performed a systematic review using Medline (1946-2018), Embase (1980-2018), Cinahl (1981-2018) and the Cochrane Controlled Register of Trials to identify studies that reported on the association between socioeconomic deprivation and survival or peri-operative outcomes in endometrial cancer patients. Included were adult women (age ≥ 18 years) diagnosed with primary endometrial cancer.

Laparoscopy versus laparotomy for the management of early stage endometrial cancer.

Background: This is an update of a previous Cochrane Review published in 2012, Issue 9.Surgery for endometrial cancer (hysterectomy with removal of both fallopian tubes and ovaries) is performed through laparotomy. It has been suggested that the laparoscopic approach is associated with a reduction in operative morbidity.

Evaluating the social fitness Programme for older people with cognitive problems and their caregivers: lessons learned from a failed trial.

Background: This process evaluation article describes the lessons learned from a failed trial which aimed to assess effectiveness of the tailor-made, multidisciplinary Social Fitness Programme to improve social participation of community-dwelling older people with cognitive problems (clients) and their caregivers (couples).

Methods: A process evaluation was performed to get insight in 1) the implementation of the intervention, 2) the context of intervention delivery from professionals' point of view, and 3) the potential impact of intervention delivery from participants' perspectives. Data was gathered using mixed-methods: questionnaires, focus group discussions, interviews, medical records.

Body mass index and sexual function in women with gynaecological cancer.

Objectives: To investigate the association between body mass index (BMI) and sexual functioning in gynaecologic cancer patients. To determine the association between socio-economic deprivation and sexual functioning.

Methods: This is a prospective cohort study on women undergoing surgery for suspected or proven gynaecological cancer between September 2014 and February 2016 in the Royal Cornwall Hospital Trust.

Social participation of people with cognitive problems and their caregivers: a feasibility evaluation of the Social Fitness Programme.

Objective: We developed a tailor-made intervention aimed at improving social participation of people with cognitive problems and their caregivers. This programme consists of an integration of healthcare and welfare interventions: occupational therapy, physiotherapy and guidance by a welfare professional. This article describes the feasibility evaluation of this Social Fitness Programme.

Reducing sample size by combining superiority and non-inferiority for two primary endpoints in the Social Fitness study.

Objectives: In randomized controlled trials, two endpoints may be necessary to capture the multidimensional concept of the intervention and the objectives of the study adequately. We show how to calculate sample size when defining success of a trial by combinations of superiority and/or non-inferiority aims for the endpoints.

Study Design And Setting: The randomized controlled trial design of the Social Fitness study uses two primary endpoints, which can be combined into five different scenarios for defining success of the trial.

Determinants of students' willingness to accept a measles-mumps-rubella booster vaccination during a mumps outbreak: a cross-sectional study.

Background: Despite high vaccination coverage, a mumps outbreak that affected mainly vaccinated university students and their contacts took place in the Netherlands in the period 2009-2012. We presented university students with a hypothetical case in which we offered them a measles, mumps, and rubella (MMR) booster vaccination to control the mumps outbreak. The aim of this study was to get insight into the determinants of university students' willingness to accept this vaccination.

Composite reliability of a workplace-based assessment toolbox for postgraduate medical education.

In recent years, postgraduate assessment programmes around the world have embraced workplace-based assessment (WBA) and its related tools. Despite their widespread use, results of studies on the validity and reliability of these tools have been variable. Although in many countries decisions about residents' continuation of training and certification as a specialist are based on the composite results of different WBAs collected in a portfolio, to our knowledge, the reliability of such a WBA toolbox has never been investigated.

An experimental electronic medical-record system with multiple views on medical narratives.

In this article we describe a prototype electronic medical-record system that has been developed specifically to facilitate searching through medical narratives, as part of a preparatory study to the development of a medical workstation. This system contains a searching structure in which several views on the medical data are combined. We describe the structure of the database and the user-interface.

A closer look at cueing effects in multiple-choice questions.

This study investigates the cueing effect occurring in multiple choice questions. Two parallel tests with matching contents were administered. By means of a computer program, examinees of different training levels and professional expertise were presented the same set of 35 cases (derived from patient problems in general practice) twice.