SOX15 exerts antitumor function in glioma by inhibiting cell proliferation and invasion via downregulation of Wnt/β-catenin signaling.

Aims: Sex-determining region of Y chromosome-related high-mobility-group box 15 (SOX15) has recently emerged as a candidate tumor-inhibitor in multiple types of human tumors. To date, the involvement of SOX15 in glioma is undetermined. The purpose of this study was to investigate the expression, function and potential molecular mechanism of SOX15 in glioma.

MicroRNA‑940 promotes cell proliferation and invasion of glioma by directly targeting Kruppel‑like factor 9.

MicroRNA‑940 (miR‑940) has been extensively studied in the pathogenesis of numerous types of human cancer; however, the expression pattern, roles and molecular mechanisms underlying the regulatory actions of miR‑940 in glioma remain unknown. The present study aimed to further investigate miR‑940 by studying its expression, roles and mechanisms of action in glioma. Reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) was used to detect miR‑940 expression in glioma tissues and cell lines.

Reinforcement of biodegradable poly(3-hydroxybutyrate-co-3-hydroxyvalerate) with cellulose nanocrystal/silver nanohybrids as bifunctional nanofillers.

Green nanocomposites containing biodegradable poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) and cellulose nanocrystals/silver (CNC-Ag) nanohybrids were synthesized and their properties were investigated. It was found that homogeneously dispersed CNC-Ag could act as bifunctional reinforcements to improve the thermal, mechanical and antibacterial properties of PHBV. Compared to pristine PHBV, the tensile strength and the maximum decomposition temperature (T) of the nanocomposite with 10 wt% CNC-Ag were enhanced by 140% and 24.