Plasma EGFR mutation ctDNA dynamics in patients with advanced EGFR-mutated NSCLC treated with Icotinib: phase 2 multicenter trial result.

Plasma epidermal growth factor receptor mutation (EGFRm) circulating tumor DNA (ctDNA) dynamics exhibit promise in predicting outcomes in patients with EGFRm-advanced non-small cell lung cancer (NSCLC). However, there remains limited trial-level data on integrating ctDNA monitoring into clinical practice. We performed a prospective, multicenter trial to investigate the relationship between EGFRm ctDNA dynamic changes and clinical outcomes in NSCLC patients with EGFRm.

Differences in the Quantitative HRCT Characteristics of Patients with Asthma, COPD and Asthma-COPD Overlap and Their Relationships with Pulmonary Function.

Purpose: We compared pulmonary function indices and quantitative CT parameters of airway remodeling, air trapping, and emphysema in asthmatic patients and patients with COPD and asthma-COPD overlap (ACO) and explored their relationships with airflow limitation.

Patients And Methods: Patients with asthma (n=48), COPD (n=52), and ACO (n=30) and controls (n=54) who completed pulmonary function tests and HRCT scans were retrospectively enrolled in our study. Quantitative CT analysis software was used to assess emphysema (LAA%), airway wall dimensions (wall area (WA), luminal area (LA), and wall area percentage (WA%)), and air trapping ((relative volume change of -860 HU to -950 HU (RVC) and the expiration-to-inspiration ratio of the mean lung density (MLD)).

Study on corrosion behavior and mechanism of AISI 4135 steel in marine environments based on field exposure experiment.

The application of high-strength steels in marine engineering is gaining importance because of their high performance and ability to help save resources. However, detailed and systematic information about the corrosion behavior of high-strength steels in different marine corrosion zones is still limited. This study aimed to investigate and compare the corrosion behavior of AISI 4135 high-strength steel in marine atmospheric, splash, tidal, and immersion zones, focusing on rust layer characteristics, corrosion form and electrochemical corrosion behavior.

Organic Compounds as Corrosion Inhibitors for Carbon Steel in HCl Solution: A Comprehensive Review.

Most studies on the corrosion inhibition performance of organic molecules and (nano)materials were conducted within "carbon steel/1.0 M HCl" solution system using similar experimental and theoretical methods. As such, the numerous research findings in this system are sufficient to conduct comparative studies to select the best-suited inhibitor type that generally refers to a type of inhibitor with low concentration/high inhibition efficiency, nontoxic properties, and a simple and cost-economic synthesis process.

HRCT quantitative analysis of airway remodeling and airway trapping in the small airway asthma phenotype and its correlation with pulmonary function.

Objectives: We aimed to explore whether large airway remodeling and small airway structural changes exist in subjects with small airway asthma phenotype and to evaluate the relationships between quantitative high-resolution computed tomography (qHRCT) parameters and lung function.

Methods: We enrolled 15 subjects with small airway asthma phenotype and 18 healthy controls. The two groups were matched by age, sex and body square area (BSA) with propensity score matching (PSM).

The Value of Impulse Oscillometric Parameters and Quantitative HRCT Parameters in Differentiating Asthma-COPD Overlap from COPD.

Purpose: To evaluate the value of impulse oscillometry (IOS) and quantitative HRCT parameters for differentiating asthma-COPD overlap (ACO) in COPD patients.

Patients And Methods: We enrolled 44 controls and 66 COPD patients, divided into the pure COPD group (n=40) and the ACO group (n=26). Spearman correlation analysis was utilized to assess the relationship between the quantitative HRCT and IOS parameters.

The Value of Fractional Exhaled Nitric Oxide and Impulse Oscillometric and Spirometric Parameters for Predicting Bronchial Hyperresponsiveness in Adults with Chronic Cough.

Purpose: To evaluate the contribution of fractional exhaled nitric oxide (FeNO) and impulse oscillometry (IOS) and spirometric parameters in predicting bronchial hyperresponsiveness (BHR) in adults with chronic cough.

Patients And Methods: In total, 112 patients with chronic cough were enrolled in this prospective diagnostic study. Receiver operating characteristic (ROC) curves were generated to assess the diagnostic efficiency and optimal cut-off values of FeNO and IOS and spirometric parameters in predicting BHR.

Value of Combining of the NLR and the Fibrinogen Level for Predicting Stroke-Associated Pneumonia.

Purpose: To evaluate the value of the NLR (neutrophil-to-lymphocyte ratio) and the fibrinogen level in predicting stroke-associated pneumonia (SAP) in acute ischemic stroke (AIS) patients.

Patients And Methods: In total, we enrolled 734 medical-ward patients with AIS in this retrospective study. Patients were divided into SAP (n=52) and non-SAP (n=682) groups according to the diagnostic criteria of SAP.

BiSe Sensitized TiO Nanotube Films for Photogenerated Cathodic Protection of 304 Stainless Steel Under Visible Light.

Titanium dioxide (TiO) nanotube arrays coupled with a narrow gap semiconductor-bismuth selenide (BiSe)-exhibited remarkable enhancement in the photocathodic protection property for 304 stainless steel under visible light. BiSe/TiO nanocomposites were successfully synthesized using a simple two-step method, including an electrochemical anodization method for preparing pure TiO and a chemical bath deposition method for synthesizing BiSe nanoflowers. The morphology and structure of the composite films were studied by scanning electron microscopy, energy dispersion spectroscopy, X-ray photoelectron spectroscopy and X-ray diffraction.