An Artificial Intelligence-Assisted Flexible and Wearable Mechanoluminescent Strain Sensor System.

The complex wiring, bulky data collection devices, and difficulty in fast and on-site data interpretation significantly limit the practical application of flexible strain sensors as wearable devices. To tackle these challenges, this work develops an artificial intelligence-assisted, wireless, flexible, and wearable mechanoluminescent strain sensor system (AIFWMLS) by integration of deep learning neural network-based color data processing system (CDPS) with a sandwich-structured flexible mechanoluminescent sensor (SFLC) film. The SFLC film shows remarkable and robust mechanoluminescent performance with a simple structure for easy fabrication.

Gut-Liver Axis: Modulating the Gut Microbiota and Its Metabolic Products as a Potential Therapeutic Strategy for the Treatment of Hepatic Ischemia-Reperfusion Injury.

Hepatic ischemia-reperfusion injury (HIRI) is a major complication reported in various clinical scenarios such as liver transplantation (LTx), hepatectomy, and acute hepatic insult. This condition affects the restoration of hepatic functionalities post-LTx. Contemporary scientific inquiries have highlighted the involvement of intestinal microbiota and their metabolic by-products in the initiation and progression of HIRI.

Triboelectric Nanogenerator for Self-Powered Gas Sensing.

With the continuous acceleration of industrialization, gas sensors are evolving to become portable, wearable and environmentally friendly. However, traditional gas sensors rely on external power supply, which severely limits their applications in various industries. As an innovative and environmentally adaptable power generation technology, triboelectric nanogenerators (TENGs) can be integrated with gas sensors to leverage the benefits of both technologies for efficient and environmentally friendly self-powered gas sensing.

Analysis and profiling of the purple acid phosphatase gene family in wheat (Triticum aestivum L.).

Purple acid phosphatases (PAPs) play a vital role in plant phosphorus nutrition, serving as a crucial family of metallo-phosphoesterase enzymes. This research aimed to identify the PAP genes from the A/B/D genomes of Triticum aestivum to elucidate evolutionary mechanisms of the gene family in plants and provide genomic information for subsequent research on phosphorous-use efficiency in wheat crops. In total, 105 PAP genes (TaPAPs) were identified from the A/B/D genomes by using the Arabidopsis thaliana and Oryza sativa PAP protein sequences as queries for BLASTP against the wheat protein database.

BR regulates wheat root salt tolerance by maintaining ROS homeostasis.

Trace amounts of epibrassinolide (EpiBL) could partially rescue wheat root length inhibition in salt-stressed situation by scavenging ROS, and ectopic expression of TaDWF4 or TaBAK1 enhances root salt tolerance in Arabidopsis by balancing ROS level. Salt stress often leads to ion toxicity and oxidative stress, causing cell structure damage and root development inhibition in plants. While prior research indicated the involvement of exogenous brassinosteroid (BR) in plant responses to salt stress, the precise cytological role and the function of BR in wheat root development under salt stress remain elusive.

A Room Temperature Trimethylamine Gas Sensor Based on Electrospinned Molybdenum Oxide Nanofibers/TiCT MXene Heterojunction.

The combination of two-dimensional material MXene and one-dimensional metal oxide semiconductor can improve the carrier transmission rate, which can effectively improve sensing performance. We prepared a trimethylamine gas sensor based on MoO nanofibers and layered TiCT MXene. Using electrospinning and chemical etching methods, one-dimensional MoO nanofibers and two-dimensional TiCT MXene nanosheets were prepared, respectively, and the composites were characterized via XPS, SEM, and TEM.

Expression of lncRNAs in glioma: A lighthouse for patients with glioma.

Glioma is the most common malignant tumour in the central nervous system, accounting for approximately 30 % of the primary tumours of this system. The World Health Organization grades for glioma include: Grade I (pilocytic astrocytoma), Grade II (astrocytoma, oligodastoma, etc.), Grade III (anaplastic astrocytoma, anaplastic oligodastoma, etc.

A Comprehensive Pan-cancer Analysis of the Biological Immunomodulatory Function and Clinical Value of .

is an immunological checkpoint gene, plays a critical function inInhibition or activation of cancer immunity. The / axis is its pathway of action. Therefore, our goal was to examine the predictive role of in the clinical prognosis of 33 cancer types and its functions in cancer progression, as well as explore the link between pan-cancer gene expression and immune infiltration.

PDMS Film-Based Flexible Pressure Sensor Array with Surface Protruding Structure for Human Motion Detection and Wrist Posture Recognition.

Flexible pressure sensors have been widely concerned because of their great application potential in the fields of electronic skin, human-computer interaction, health detection, and so on. In this paper, a flexible pressure sensor is designed, with polydimethylsiloxane (PDMS) films with protruding structure as elastic substrate and poly(3,4-ethylenedioxythiophene)/poly(styrenesulfonate) (PEDOT:PSS)/cellulose nanocrystals (CNC) as conductive-sensitive material. The flexible pressure sensor has a wide linear detection range (0-100 kPa), outstanding sensitivity (2.

MXene/PPy@PDMS sponge-based flexible pressure sensor for human posture recognition with the assistance of a convolutional neural network in deep learning.

The combination of flexible sensors and deep learning has attracted much attention as an efficient method for the recognition of human postures. In this paper, an in situ polymerized MXene/polypyrrole (PPy) composite is dip-coated on a polydimethylsiloxane (PDMS) sponge to fabricate an MXene/PPy@PDMS (MPP) piezoresistive sensor. The sponge sensor achieves ultrahigh sensitivity (6.

Multifunctional, Self-Adhesive MXene-Based Hydrogel Flexible Strain Sensors for Hand-Written Digit Recognition with Assistance of Deep Learning.

The conductive hydrogel as a flexible sensor not only has certain mechanical flexibility but also can be used in the field of human health detection and human-computer interaction. Herein, by introduction of tannic acid (TA) with MXene into the polyacrylamide (PAM)/carboxymethyl chitosan (CMC) double-network hydrogel, a hydrogel with high stretchability, self-adhesion, and high sensitivity was prepared. CMC and PAM form a semi-interpenetrating double-network of high toughness and durability through electrostatic interactions and multiple hydrogen bonding networks.

ACVRL1 drives resistance to multitarget tyrosine kinase inhibitors in colorectal cancer by promoting USP15-mediated GPX2 stabilization.

Background: Multitarget tyrosine kinase inhibitors (mTKIs) such as Regorafenib and Sorafenib have already been approved for the treatment of many solid tumours. However, the efficacy of mTKIs in colorectal cancer (CRC) is limited; the underlined mechanism remains largely elusive. Our study was aimed to find out the resistance mechanism of mTKIs in CRC.

RPL34-Divergent Transcript, a Novel Long NonCoding Ribonucleic Acid, Promotes Migration by Activating Epithelial-Mesenchymal Transition in Glioma.

Objective: Glioma is one of the leading causes of death in patients with intracranial tumours. RPL34 divergent transcript (RPL34-DT) is a long non-coding ribonucleic acid that is significantly upregulated in glioma tissues. However, the role of RPL34-DT in glioma behavior remains to be elucidated.

Efficient Fabrication of TPU/MXene/Tungsten Disulfide Fibers with Ultra-Fast Response for Human Respiratory Pattern Recognition and Disease Diagnosis via Deep Learning.

Flexible wearable pressure sensors have received increasing attention as the potential application of flexible wearable devices in human health monitoring and artificial intelligence. However, the complex and expensive process of the conductive filler has limited its practical production and application on a large scale to a certain extent. This study presents a kind of piezoresistive sensor by sinking nonwoven fabrics (NWFs) into tungsten disulfide (WS) and TiCT MXene solutions.

Constructing a novel signature and predicting the immune landscape of colon cancer using N6-methylandenosine-related lncRNAs.

Colon cancer (CC) is a prevalent malignant tumor that affects people all around the world. In this study, N6-methylandenosine-related long non-coding RNAs (m6A-related lncRNAs) in 473 colon cancers and 41 adjacent tissues of CC patients from The Cancer Genome Atlas (TCGA) were investigated. The Pearson correlation analysis was conducted to examine the m6A-related lncRNAs, and the univariate Cox regression analysis was performed to screen 38 prognostic m6A-related lncRNAs.

Waterproof Flexible Pressure Sensors Based on Electrostatic Self-Assembled MXene/NH-CNTs for Motion Monitoring and Electronic Skin.

Flexible wearable sensors to monitor human movement and for electronic skins must exhibit high sensitivity, a wide detection range, and waterproof characteristics. This work reports a flexible, highly sensitive, and waterproof sponge pressure sensor (SMCM). The sensor is made by assembling SiO (S), MXene (M), and NH-CNTs (C) on the backbone of melamine sponge (M).

Triboelectric Nanogenerators Based on Super-Stretchable Conductive Hydrogels with the Assistance of Deep-Learning for Handwriting Recognition.

Nowadays, wearable electronic devices are developing rapidly with the internet of things and human-computer interactions. However, there are problems such as low power, short power supply time, and difficulty in charging, leading to a limited range of practical applications. In this paper, a composite hydrogel composed of polyacrylamide, hydroxypropyl methylcellulose, and MXene (TiCT) nanosheets was developed, which formed a stable double-chain structure by hydrogen bonding.

Self-Adhesive, Anti-Freezing MXene-Based Hydrogel Strain Sensor for Motion Monitoring and Handwriting Recognition with Deep Learning.

Flexible strain sensors based on self-adhesive, high-tensile, super-sensitive conductive hydrogels have promising application in human-computer interaction and motion monitoring. Traditional strain sensors have difficulty in balancing mechanical strength, detection function, and sensitivity, which brings challenges to their practical applications. In this work, the double network hydrogel composed of polyacrylamide (PAM) and sodium alginate (SA) was prepared, and MXene and sucrose were used as conductive materials and network reinforcing materials, respectively.

Application of small extracellular vesicles in the diagnosis and prognosis of nasopharyngeal carcinoma.

Nasopharyngeal carcinoma (NPC) is a malignant tumor originating from the epithelium of the nasopharynx. The disease is insidious, and most patients are diagnosed at the advanced stage, resulting in poor prognosis. Early diagnosis is important to reduce NPC mortality.

Nifuroxazide inhibits the growth of glioblastoma and promotes the infiltration of CD8 T cells to enhance antitumour immunity.

Introduction: Glioblastoma is a primary intracranial tumour with extremely high disability and fatality rates among adults. Existing diagnosis and treatment methods have not significantly improved the overall poor prognosis of patients. Nifuroxazide, an oral antibiotic, has been reported to act as a tumour suppressor in a variety of tumours and to participate in the process of antitumour immunity.

Ultrastretchable, Self-Healing Conductive Hydrogel-Based Triboelectric Nanogenerators for Human-Computer Interaction.

The rapid development of wearable electronic devices and virtual reality technology has revived interest in flexible sensing and control devices. Here, we report an ionic hydrogel (PTSM) prepared from polypropylene amine (PAM), tannic acid (TA), sodium alginate (SA), and MXene. Based on the multiple weak H-bonds, this hydrogel exhibits excellent stretchability (strain >4600%), adhesion, and self-healing.

In Situ Polymerized MXene/Polypyrrole/Hydroxyethyl Cellulose-Based Flexible Strain Sensor Enabled by Machine Learning for Handwriting Recognition.

Flexible strain sensors have significant progress in the fields of human-computer interaction, medical monitoring, and handwriting recognition, but they also face many challenges such as the capture of weak signals, comprehensive acquisition of the information, and accurate recognition. Flexible strain sensors can sense externally applied deformations, accurately measure human motion and physiological signals, and record signal characteristics of handwritten text. Herein, we prepare a sandwich-structured flexible strain sensor based on an MXene/polypyrrole/hydroxyethyl cellulose (MXene/PPy/HEC) conductive material and a PDMS flexible substrate.

Rapid simultaneous SERS detection of dual myocardial biomarkers on single-track finger-pump microfluidic chip.

Acute myocardial infarction (AMI) is a serious disease with high mortality that afflicts many people around the world. The main cause of death from AMI was the inaccurate early diagnosis, which resulted from the medical treatment might be a delay. Therefore, it is crucial to achieve the rapid detection of AMI.