Effect of Pressure Conditions in Uterine Decellularization Using Hydrostatic Pressure on Structural Protein Preservation.

Uterine regeneration using decellularization scaffolds provides a novel treatment for uterine factor infertility. Decellularized scaffolds require maximal removal of cellular components and minimal damage to the extracellular matrix (ECM). Among many decellularization methods, the hydrostatic pressure (HP) method stands out due to its low cytotoxicity and superior ECM preservation compared to the traditional detergent methods.

Recycling iron from pickling sludge to activate peroxydisulfate for the degradation of phenol.

In this work, iron was recovered from a kind of iron-rich pickling sludge by an acid leaching process, and the recycled iron was used as a catalyst to activate peroxydisulfate (PS) for the degradation of phenol. Different kinds of sludge catalysts were prepared by different drying methods such as ordinary drying (Ods), freeze drying (Fds) and vacuum drying (Vds). The degradation performance of the different catalysts/PS system under different conditions was explored, the vacuum drying sludge catalyst (Vds) has the best activity in a wide pH range (pH = 3-10) and a wide temperature range (0-40 °C).

HIV Distal Neuropathic Pain Is Associated with Smaller Ventral Posterior Cingulate Cortex.

Objective: . Despite modern antiretroviral therapy, HIV-associated neuropathy is one of the most prevalent, disabling and treatment-resistant complications of HIV disease. The presence and intensity of distal neuropathic pain is not fully explained by the degree of peripheral nerve damage.

HIV-associated distal neuropathic pain is associated with smaller total cerebral cortical gray matter.

Despite modern antiretroviral therapy, HIV-associated sensory neuropathy affects over 50 % of HIV patients. The clinical expression of HIV neuropathy is highly variable: many individuals report few symptoms, but about half report distal neuropathic pain (DNP), making it one of the most prevalent, disabling, and treatment-resistant complications of HIV disease. The presence and intensity of pain is not fully explained by the degree of peripheral nerve damage, making it unclear why some patients do, and others do not, report pain.

Application of a rapid and efficient quantitative analysis method for traditional Chinese medicines: the case study of quality assessment of Salvia miltiorrhiza Bunge.

A reference extractive, containing multiple active known compounds, has been considered to be an alternative to individual reference standards. However, in the Chinese Pharmacopoeia (ChP) the great majority of reference extractives have been primarily used for qualitative identification by thin-layer chromatography (TLC) and few studies on the applicability of reference extractives for quantitative analysis have been presented. Using Salvia miltiorrhiza Bunge as an example in this paper, we first present a preliminary discussion on the feasibility and applicability of reference extractives for the quantitative analysis of TCMs.

[Optimization of processing technologies for dipsaci radix habitat by comprehensive evaluation method].

Objective: To optimize the processing technologies of Dipsaci Radix by comprehensive method.

Methods: According to the Chinese Pharmacopoeia (2010 edition), UV Spectrophotometry and HPLC analysis were used to determine the contents of total saponins, saponins VI of water extract and alcohol extract of Dipsaci Radix. Comprehensive evaluation method was used to optimize the processing technologies for Dipsaci Radix habitat.

[Study on optimization method of dynamic extraction process].

Objective: To establish a new optimized extraction process based on dynamic changes in extract concentration during the extraction process.

Method: Sanqi was taken as an example to compare the concentration of marker components, total solids yield and similarity evaluation of the fingerprint images of extracts by orthogonal design optimization process and dynamic optimization process to assess the feasibility of dynamic process optimization method.

Result: The concentration of marker components and total solids yield vary less than 5%, with a 100% of similarity in fingerprints, indicating basic coincidence between extracts by the two optimized processes.