Transcerebral information coordination in directional hippocampus-prefrontal cortex network during working memory based on bimodal neural electrical signals.

Working memory (WM) is a kind of advanced cognitive function, which requires the participation and cooperation of multiple brain regions. Hippocampus and prefrontal cortex are the main responsible brain regions for WM. Exploring information coordination between hippocampus and prefrontal cortex during WM is a frontier problem in cognitive neuroscience.

Concurrent interactions between prefrontal cortex and hippocampus during a spatial working memory task.

Spatial working memory (SWM) refers to a short-term system for temporary manipulation of spatial information and requires the cooperation of multiple brain regions. Despite evidence that the hippocampus (HPC) and prefrontal cortex (PFC) are involved in SWM, how the PFC and HPC interact during SWM remains puzzling. In this study, local field potentials (LFPs) were recorded simultaneously from rat ventral HPC and medial PFC during SWM tasks firstly.

The dynamic properties of a brain network during working memory based on the algorithm of cross-frequency coupling.

Working memory (WM) refers to a memory system with limited energy for short-term maintenance and plays an important role in cognitive functions. At present, research regarding WM mostly focuses on the coordination between neural signals in the signal microelectrode channel. However, how neural signals coordinate the coding of WM at the network level is rarely studied.