The Antifungal Effects of Berberine and Its Proposed Mechanism of Action Through CYP51 Inhibition, as Predicted by Molecular Docking and Binding Analysis.

Fungal infections present a significant health risk, particularly in immunocompromised individuals. Berberine, a natural isoquinoline alkaloid, has demonstrated broad-spectrum antimicrobial activity, though its antifungal potential and underlying mechanisms against both yeast-like and filamentous fungi are not fully understood. This study investigates the antifungal efficacy of berberine against , , , and in vitro, as well as its therapeutic potential in a murine model of cryptococcal infection.

Effects of Taurine and Vitamin C on the Improvement of Antioxidant Capacity, Immunity and Hypoxia Tolerance in Gibel Carp ().

To investigate the effects of taurine and vitamin C on gibel carp (), fish (41.85 ± 0.03 g) were fed three diets with 0% taurine + 0% vitamin C (D0), 0.

Experimental realization of multiple frequency photoassociation in an optical dipole trap.

The generation of cold molecules is an important topic in the field of cold atoms and molecules and has received relevant advanced research attention in ultracold chemistry, quantum computation, and quantum metrology. With a high atomic phase space density, optical dipole traps have been widely used to prepare, trap, and study cold molecules. In this work, Rb2 molecules were photoassociated in a magneto-optical trap to obtain a precise rovibrational spectrum, which provided accurate numerical references for the realization of multiple frequency photoassociation.

Role of Cholecystokinin () in Feeding Regulation of Largemouth Bass (): Peptide Activation and Antagonist Inhibition.

This study investigated the role of cholecystokinin () in the feeding regulation of largemouth bass () via peptide activation and antagonist inhibition. The results show that the gene was expressed in various tissues, with the highest expression level occurring in the brain. Feeding, continuous feeding, and refeeding after fasting could significantly improve the mRNA levels of in the brain.

Transcriptome-Based Analysis of the Mechanism of Action of Metabolic Disorders Induced by Waterborne Copper Stress in .

To reveal the effects of waterborne copper stress on gene expression changes, molecular pathways, and physiological functions in , juvenile fish were equally divided into two experimental groups, and the copper levels were 1.61 ± 0.03 mg/L (copper-exposed group) and 0 mg/L (control group), respectively.

Background-free imaging of cold atoms in optical traps.

Optical traps, including those used in atomic physics, cold chemistry, and quantum science, are widely used in the research on cold atoms and molecules. Owing to their microscopic structure and excellent operational capability, optical traps have been proposed for cold atom experiments involving complex physical systems, which generally induce violent background scattering. In this study, using a background-free imaging scheme in cavity quantum electrodynamics systems, a cold atomic ensemble was accurately prepared below a fiber cavity and loaded into an optical trap for transfer into the cavity.

DL-Methionyl-DL-Methionine/DL-Methionine Supplementation Alleviated the Adverse Effects of Dietary Low Fishmeal Levels on Growth and Intestinal Health of .

DL-methionyl-DL-methionine (AQUAVI® Met-Met) (Met-Met) (0.10%, 0.20%, 0.

Association Between COVID-19 and Neurological Diseases: Evidence from Large-Scale Mendelian Randomization Analysis and Single-Cell RNA Sequencing Analysis.

Observational studies have suggested that SARS-CoV-2 infection increases the risk of neurological diseases, but it remains unclear whether the association is causal. The present study aims to evaluate the causal relationships between SARS-CoV-2 infections and neurological diseases and analyzes the potential routes of SARS-CoV-2 entry at the cellular level. We performed Mendelian randomization (MR) analysis with CAUSE method to investigate causal relationship of SARS-CoV-2 infections with neurological diseases.

Different Starch Sources Affect the Growth Performance and Hepatic Health Status of Largemouth Bass () in a High-Temperature Environment.

The experiment was designed to investigate the effects of different starch types on the growth performance and liver health status of largemouth bass in a high-temperature environment (33-35 °C). In this study, we designed five diets using corn starch (CS), tapioca starch (TS), sweet potato starch (SPS), potato starch (PS), and wheat starch (WS) as the starch sources (10%). We selected 225 healthy and uniformly sized largemouth bass (199.

Enzymatically Hydrolyzed Poultry By-Product Supplementation, Instead of Fishmeal, Alone Improves the Quality of Largemouth Bass () Back Muscle without Compromising Growth.

This study was designed to investigate the effects of enzymatically hydrolyzed poultry by-products (EHPB) on the growth and muscle quality of largemouth bass. Different concentrations of EHPB (0.00, 3.

Phenylalanine Plays Important Roles in Regulating the Capacity of Intestinal Immunity, Antioxidants and Apoptosis in Largemouth Bass ().

This experiment was planned to explore the role of dietary phenylalanine levels in intestinal immunity, antioxidant activity and apoptosis in largemouth bass (). Six iso-nitrogen and iso-energy diets with phenylalanine levels of 1.45% (DPHE1), 1.

Sodium chloride alleviates oxidative stress and physiological responses induced by extreme winter cold in genetically improved farmed tilapia (GIFT; Oreochromis niloticus).

A 6-week trial was designed to investigate the effects of dietary sodium chloride supplementation on physiological, metabolic, and molecular stress response parameters. The findings showed that (1) there were no significant differences between sodium chloride supplementation groups (0.05S, 0.

Dietary Supplementation of Effectively Enhanced the Intestinal Antioxidant Capacity and Immune Status of .

An fish meal diet was supplemented with 0 (CHL0, Control), 38 (CHL38), 76 (CHL76), 114 (CHL114), and 152 (CHL152) mg/kg for 60 days, and their serum and intestinal samples were analyzed. The results showed that the albumin (ALB) and total protein (TP) contents were observably enhanced in the CHL76 group compared with the Control group. The intestinal glutathione (GSH) and glutathione peroxidase (GSH-Px) contents were enhanced significantly in the CHL76 group, while the total antioxidant capacity (T-AOC) was enhanced in the CHL38 group, compared with the Control group.

The Role of Algae Extract ( and ) in Fishmeal Substitution in Gibel Carp ().

The function of algae extract (AE) in fishmeal (FM) substitution with plant proteins in the diets of Gibel carp () was investigated during a 56-day trial. Diets 1 and 2 contained 10% FM, Diets 3 and 4 contained 5% FM, and Diet 5 and 6 contained 0% FM. In contrast, Diets 2, 4, and 6 were supplemented with 0.

A Modular Approach for the Synthesis of Natural and Artificial Terpenoids.

Many terpenoids with isoprene unit(s) demonstrating critical biological activities have been isolated and characterized. In this study, we have developed a robust chem-stamp strategy for the construction of the key isoprene unit, which consists of two steps: one-carbon extension of aldehydes to the alkenyl boronates by the boron-Wittig reaction and the rhodium-catalyzed reaction of alkenyl boronates with 2,3-allenols to yield enals. This chem-stamp could readily be applied repeatedly and separately, enabling the modular concise synthesis of many natural and pharmaceutically active terpenoids, including retinal, β-carotene, vitamin A, tretinoin, fenretinide, acitretin, ALRT1550, nigerapyrone C, peretinoin, and lycopene.

Integrated bioinformatics and experimental validation reveal the role of JARID2 in ovarian cancer.

To develop novel prognostic markers for early detection and prognosis of ovarian cancer (OC). We utilized bioinformatics analysis to identify and construct a prognostic model consisting of lncRNAs centered around JARID2 and explored the potential ceRNA network in OC. Cell functional experiments were conducted to validate the reliability of the ceRNA network and investigate the functional role of JARID2 in OC.

Continuously and widely tunable frequency-stabilized laser based on an optical frequency comb.

Continuously and widely tunable lasers, actively stabilized on a frequency reference, are broadly employed in atomic, molecular, and optical (AMO) physics. The frequency-stabilized optical frequency comb (OFC) provides a novel optical frequency reference, with a broadband spectrum that meets the requirement of laser frequency stabilization. Therefore, we demonstrate a frequency-stabilized and precisely tunable laser system based on it.

Feedback and compensation scheme to suppress the thermal effects from a dipole trap beam for the optical fiber microcavity.

Cavity quantum electrodynamics (cavity QED) with neutral atoms is a promising platform for quantum information processing and optical fiber Fabry-Pérot microcavity with small mode volume is an important integrant for the large light-matter coupling strength. To transport cold atoms to the microcavity, a high-power optical dipole trap (ODT) beam perpendicular to the cavity axis is commonly used. However, the overlap between the ODT beam and the cavity mirrors causes thermal effects inducing a large cavity shift at the locking wavelength and a differential cavity shift at the probe wavelength which disturbs the cavity resonance.

Effects of Cinobufagin on the Proliferation, Migration, and Invasion of H1299 Lung Cancer Cells.

Cinobufagin (CB), with its steroidal nucleus structure, is one of the major, biologically active components of Chan Su. Recent studies have shown that CB exerts inhibitory effects against numerous cancer cells. However, the effects of CB regarding the metastasis of non-small cell lung cancer (NSCLC) and the involved mechanisms need to be further studied.