Antibiotic-resistant ribosome variants arise spontaneously in bacterial populations; however, their impact on the overall bacterial physiology remains unclear. We studied the naturally arising antibiotic-resistant L22* ribosome variant of and identified a Mg-dependent physiological cost. Coculture competition experiments show that Mg limitation hinders the growth of the L22* variant more than the wild type (WT), even under antibiotic pressure.
View Article and Find Full Text PDFBackground: Posttransplantation diabetes mellitus (PTDM) is a crucial problem after kidney transplantation. We aimed to determine whether metformin affects cardiovascular and graft outcomes in patients with PTDM.
Methods: This retrospective cohort study included 1,663 kidney transplant recipients without preexisting diabetes mellitus.
It is essential to understand the barrier height, ideality factor, and role of inhomogeneities at the metal/semiconductor interfaces in nanowires for the development of next generation nanoscale devices. Here, we investigate the drain current ()-gate voltage () characteristics of GaN nanowire wrap-gate transistors (WGTs) for various gate potentials in the wide temperature range of 130-310 K. An anomalous reduction in the experimental barrier height and rise in the ideality factor with reducing the temperature have been perceived.
View Article and Find Full Text PDFAnnu Int Conf IEEE Eng Med Biol Soc
July 2023
We used capacitance-voltage (-), conductance-voltage (-), and noise measurements to examine the carrier trap mechanisms at the surface/core of an AlGaN/GaN nanowire wrap-gate transistor (WGT). When the frequency is increased, the predicted surface trap density promptly drops, with values ranging from 9.1 × 10 eV∙cm at 1 kHz to 1.
View Article and Find Full Text PDFBackground: Dual-energy (DE) chest radiography (CXR) enables the selective imaging of two relevant materials, namely, soft tissue and bone structures, to better characterize various chest pathologies (i.e., lung nodule, bony lesions, etc.
View Article and Find Full Text PDFIn the present study, novel InVO/SnWO nanocomposites with different concentrations of SnWO were successfully prepared using a facile hydrothermal technique and investigated employing a wide range of analytical methods for efficient photocatalytic degradation of tetracycline (TC). X-ray diffraction analysis showed the presence of the orthorhombic phases of both InVO and SnWO in the composite catalyst. Dispersion of SnWO nanoplates over the InVO nanosheets enhanced the synergistic interactions, improving the separation of charge carriers and their transfer.
View Article and Find Full Text PDFAnn Palliat Med
October 2022
Background: Lipid profile as a prognostic factor in terminal cancer patients is controversial. This study aimed to provide useful information related to the treatment of patients with terminal cancer by examining lipid profiles and their association with survival time.
Methods: We retrospectively reviewed the medical records of 428 inpatients who died while receiving palliative care a university hospital in Daegu during September 2015-September 2020 and then analyzed differences in survival times and the relative risk associated with lipid profiles.
The development of excellent photocatalysts is of great significance for the efficient photocatalytic degradation process, however, the low carrier separation efficiency and poor light absorption ability typically limit the performance of photocatalysts. Herein, a visible light responsive heterostructure composed with indium vanadium oxide nanosheets supported bismuth tungsten oxide nanoflakes (InVO/BiWO) was synthetized through in-situ hydrothermal method. Further, the photocatalytic activity was performed for tetracycline (TC) under visible light illumination.
View Article and Find Full Text PDFBased on an analysis of the signal characteristics of gas sensors, this work presents a chemoresistive sensor readout circuit design for detecting gases with slow response time characteristics. The proposed readout circuit directly generates a reference voltage corresponding to the initial value of the gas sensor and extracts only the amount of gas concentration change in the sensor. Because the proposed readout circuit can adaptively regenerate the suitable reference voltage under various changing ambient conditions, it can alleviate the variation in output values at the same gas concentration caused by non-uniformities among gas sensors.
View Article and Find Full Text PDFContrary to multicellular organisms that display segmentation during development, communities of unicellular organisms are believed to be devoid of such sophisticated patterning. Unexpectedly, we find that the gene expression underlying the nitrogen stress response of a developing Bacillus subtilis biofilm becomes organized into a ring-like pattern. Mathematical modeling and genetic probing of the underlying circuit indicate that this patterning is generated by a clock and wavefront mechanism, similar to that driving vertebrate somitogenesis.
View Article and Find Full Text PDFThe immunomodulatory effects of HDB1258 were evaluated in mice with colitis induced by (KO). HDB1258 was cultured in the lava seawater (LS) to improve its probiotic properties. It increased adhesive ability to mucin with mRNA expression levels of chaperone proteins (such as GroEL/ES, DnaKJ, and HtrA).
View Article and Find Full Text PDFJ Appl Clin Med Phys
October 2021
In this study, breast phantoms were fabricated by emulating glandular and adipose tissues separately using a three-dimensional (3D) printer. In addition, direct and quantitative glandular dose evaluations were performed. A quantitative method was developed to evaluate the glandular and adipose tissues separately when performing glandular dose evaluations.
View Article and Find Full Text PDFJ Hazard Mater
February 2022
A simple hydrothermal approach was demonstrated for synthesizing a coupled NiFeO-ZnWO nanocomposite, wherein one-dimensional ZnWO nanorods were inserted into two-dimensional NiFeO nanoplates. Herein, we evaluated the photocatalytic removal of Cr(VI), and degradation of tetracycline (TC) and methylene blue (MB) by the nanocomposite, as well as its ability to split water. The ZnWO nanorods enriched the synergistic interactions, upgraded the solar light fascination proficiency, and demonstrated outstanding detachment and migration of the photogenerated charges, as confirmed by a transient photocurrent study and electrochemical impedance spectroscopy measurements.
View Article and Find Full Text PDFOver the past few years, industrial pollution has had a negative impact on aquatic life by releasing significant amounts of hazardous chemicals into the ecosystem. Therefore, it is imperative to develop photocatalytic materials with good photocatalytic activity and easy separation. Photocatalytic degradation has been employed for the removal of such contaminants using binary hybrid nanocomposites as photocatalysts.
View Article and Find Full Text PDFPurpose: Megavoltage computed tomography (MVCT) offers an opportunity for adaptive helical tomotherapy. However, high noise and reduced contrast in the MVCT images due to a decrease in the imaging dose to patients limits its usability. Therefore, we propose an algorithm to improve the image quality of MVCT.
View Article and Find Full Text PDFThe engineering of C photosynthetic activity into the C plant rice has the potential to nearly double rice yields. To engineer a two-cell photosynthetic system in rice, the rice bundle sheath (BS) must be rewired to enhance photosynthetic capacity. Here, we show that BS chloroplast biogenesis is enhanced when the transcriptional activator, Oryza sativa Cytokinin GATA transcription factor 1 (OsCGA1), is driven by a vascular specific promoter.
View Article and Find Full Text PDFIEEE Trans Neural Syst Rehabil Eng
August 2021
We synthesized phenylboronic acid pinacol ester (PBPE)-conjugated hyaluronic acid (HA) via thiobis(ethylamine) (TbEA) linkage (abbreviated as HAsPBPE conjugates) to fabricate the radiosensitive delivery of caffeic acid phenetyl ester (CAPE) and for application in radioprotection. PBPE was primarily conjugated with TbEA and then PBPE-TbEA conjugates were conjugated again with hyaluronic acid using carbodiimide chemistry. CAPE-incorporated nanoparticles of HAsPBPE were fabricated by the nanoprecipitation method and then the organic solvent was removed by dialysis.
View Article and Find Full Text PDFBackground: Gut microbiota closely communicate in the immune system to maintain a balanced immune homeostasis in the gastrointestinal tract of the host. Oral administration of probiotics modulates gut microbiota composition. In the present study, we isolated Lactobacillus rhamnosus HDB1258, which induced tumor necrosis factor (TNF)-α and interleukin (IL)-10 expression in macrophages, from the feces of breastfeeding infants and examined how HDB1258 could regulate the homeostatic immune response in mice with or without lipopolysaccharide (LPS)-induced systemic inflammation.
View Article and Find Full Text PDFBacteria exhibit cell-to-cell variability in their resilience to stress, for example, following antibiotic exposure. Higher resilience is typically ascribed to "dormant" non-growing cellular states. Here, by measuring membrane potential dynamics of Bacillus subtilis cells, we show that actively growing bacteria can cope with ribosome-targeting antibiotics through an alternative mechanism based on ion flux modulation.
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