Systematic training of table tennis players' physical performance based on artificial intelligence technology and data fusion of sensing devices.

This research emphasises the value of physical training for table tennis players, particularly as ball speed and spin rate decline and emphasises how important intensity quality is to the game. Chinese table tennis players' dual identities place greater demands on the general growth of their learning and training as a crucial component of talent development preparation. Athletes' general quality, competitive level, and ability to avoid sports injuries are all improved by scientific and focused physical training.

Patient-Derived Organoids Can Guide Personalized-Therapies for Patients with Advanced Breast Cancer.

Most breast cancers at an advanced stage exhibit an aggressive nature, and there is a lack of effective anticancer options. Herein, the development of patient-derived organoids (PDOs) is described as a real-time platform to explore the feasibility of tailored treatment for refractory breast cancers. PDOs are successfully generated from breast cancer tissues, including heavily treated specimens.

Functional lncRNA-miRNA-mRNA Networks in Response to Baicalein Treatment in Hepatocellular Carcinoma.

Introduction: Baicalein has been shown to have antitumor activities in several cancer types. However, its acting mechanisms remain to be further investigated. This work is aimed at exploring the functional long noncoding RNA (lncRNA)/microRNA (miRNA)/messenger RNA (mRNA) triplets in response to baicalein in hepatocellular carcinoma (HCC) cell to understand the mechanisms of baicalein in HCC.

An artificial cell system for biocompatible gene delivery in cancer therapy.

The gene therapy of cancer is generally recognized as a promising approach for the reversal of neoplastic progress of cancer cells. However, the lack of biocompatibility as well as highly available carriers is the bottleneck in gene therapy. In recent years, with the advances of understanding in cell signaling and cell based functions, the development of cell mimic carriers is showing great potential in evaluating the anticancer efficacy of drugs.

Correction: Paclitaxel prodrug based mixed micelles for tumor-targeted chemotherapy.

[This corrects the article DOI: 10.1039/C7RA07796C.].

Comprehensive analysis of pseudogene HSPB1P1 and its potential roles in hepatocellular carcinoma.

The incidence and mortality rate of hepatocellular carcinoma (HCC) nowadays is still at high levels. The regulatory roles of pseudogene in cancers have been gradually recognized in recent years. However, comprehensive investigation of abnormally expressed pseudogene and related mechanisms in HCC remains lacking.

Analysis of miRNA-mRNA regulatory network revealed key genes induced by aflatoxin B1 exposure in primary human hepatocytes.

Background: Aflatoxin B1 (AFB1) exposure is a crucial factor to initiate hepatocellular carcinoma (HCC). However, comprehensive microRNA (miRNA)-message RNA (mRNA) regulatory network regarding AFB1-associated HCC is still lacking. This work was aimed to identify miRNA-mRNA network in primary human hepatocytes after AFB1 exposure.

Identification of aberrantly expressed lncRNA and the associated TF-mRNA network in hepatocellular carcinoma.

Emerging evidence has indicated that long noncoding RNA (lncRNA) plays crucial roles in regulating hepatocellular carcinoma (HCC) progression. However, a comprehensive lncRNA-transcription factor (TF)-message RNA (mRNA) in HCC remains absent. The aim of this study was to identify aberrantly expressed lncRNAs and the associated TF-mRNA network in HCC.

Identification of lncRNA-miRNA-mRNA regulatory network associated with epithelial ovarian cancer cisplatin-resistant.

To construct a long noncoding RNA (lncRNA)-microRNA (miRNA)-messenger RNA (mRNA) regulatory network related to epithelial ovarian cancer (EOC) cisplatin-resistant, differentially expressed genes (DEGs), differentially expressed lncRNAs (DELs), and differentially expressed miRNAs (DEMs) between MDAH and TOV-112D cells lines were identified. Gene Ontology (GO) analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis were conducted to analyze the biological functions of DEGs. Downstream mRNAs or upstream lncRNAs for miRNAs were analyzed at miRTarBase 7.

Highly efficient upconversion luminescence of Er heavily doped nanocrystals through 1530 nm excitation.

Improving luminescence efficiency is of vital importance for applications of rare-earth-doped upconversion materials. Herein, we present highly efficient upconversion nanocrystal, which is brighter than the state-of-the-art Er/Yb co-doped core-shell material, through Er heavily doping and 1530 nm excitation. Moreover, upconversion characteristics and mechanisms of Er heavily doped core nanocrystals and their core-shell counterparts are investigated carefully.

Identification of hub genes to regulate breast cancer metastasis to brain by bioinformatics analyses.

Breast cancer with metastasis especially brain metastasis represents a significant cause of morbidity and mortality in patients. In this study, we aimed to investigate the hub genes and potential molecular mechanism in brain metastasis breast cancer. Expression profiles of the genes were extracted from the Gene Expression Omnibus (GEO) database.

Facile preparation of biocompatible nanostructured lipid carrier with ultra-small size as a tumor-penetration delivery system.

Insufficient tumor penetration is one of the major obstacles for satisfactory cancer therapy. As a result, the ability to push the lower limits of size for nanoparticle platforms that have traditionally existed in larger forms is highly desirable. In our study, a facile solvent diffusion method was applied to prepare an ultra-small nanostructured lipid carrier (usNLC) which was capable of encapsulating hydrophobic molecules.

Metabolic engineering of Bacillus subtilis for biosynthesis of heparosan using heparosan synthase from Pasteurella multocida, PmHS1.

Heparosan, the capsular polysaccharide discovered in many pathogenic bacteria, is a promising material for heparin preparation. In this study, the Pasteurella multocida heparosan synthase 1 (PmHS1) module was used to synthesize heparosan with controlled molecular weight, while tuaD/gtaB module or gcaD module was responsible for UDP-precursors production in Bacillus subtilis 168. After metabolic pathway optimization, the yield of heparosan was as high as 237.

Metabolic engineering of Bacillus subtilis for the efficient biosynthesis of uniform hyaluronic acid with controlled molecular weights.

Bacillus subtilis was engineered into an efficient hyaluronic acid (HA) producer by introducing two inducible artificial operons carrying HA synthase gene from Pasteurella multocida and precursor genes encoding enzymes involved in synthesis of the sugar precursors. A two-stage induction strategy was established for metabolic engineering of recombinant B. subtilis to efficiently produce uniform HA with controlled molecular weights.