The mechanism of wen jing tang in the treatment of endometriosis: Insights from network pharmacology and experimental validation.

Background: Endometriosis (EM) is a hormone-dependent condition marked by progressively severe secondary dysmenorrhea, significantly impacting patients' quality of life and overall health. Wen Jing Tang (WJT), a traditional Chinese medicinal formulation derived from the , has proven to be an effective therapeutic agent for EM. However, the precise molecular mechanisms underlying its efficacy remain unclear.

A Design Methodology for Fault-Tolerant Neuromorphic Computing Using Bayesian Neural Network.

Memristor crossbar arrays are a promising platform for neuromorphic computing. In practical scenarios, the synapse weights represented by the memristors for the underlying system are subject to process variations, in which the programmed weight when read out for inference is no longer deterministic but a stochastic distribution. It is therefore highly desired to learn the weight distribution accounting for process variations, to ensure the same inference performance in memristor crossbar arrays as the design value.

RNA sequencing profiles reveal dynamic signaling and glucose metabolic features during bone marrow mesenchymal stem cell senescence.

Background: Stem cell senescence is considered as a significant driver of organismal aging. As individuals age, the number of stem cells is declined, and the ability to proliferate and survive is also weakened. It has been reported that metabolism plays an important role in stem cell self-renewal, multilineage differentiation, senescence and fate determination, which has aroused widespread concerns.

Detection of aflatoxin B with a new label-free fluorescence aptasensor based on PVP-coated single-walled carbon nanohorns and SYBR Gold.

This paper describes a novel fluorescence label-free aptasensor to detect aflatoxin B (AFB) by utilizing SYBR Gold, aptamer, and single-walled carbon nanohorns (SWCNHs). In the presence of AFB, the conformation of AFB-specific aptamer went through and the spatial structure of this specific aptamer was transformed accordingly. Due to the resistance of the transformed aptamer when adsorbed on the surface of SWCNHs, the protection of the fluorescence of SYBR Gold was accomplished.

What Happens When People with Depression Gather Online?

Depression is a common mental disease that impacts people of all ages and backgrounds. To meet needs that cannot otherwise be met, people with depression or who tend to suffer from depression often gather in online depression communities. However, since joining a depression community exposes members to the depression of others, the impact of such communities is not entirely clear.

Novel nanomicelles based on rebaudioside A: A potential nanoplatform for oral delivery of honokiol with enhanced oral bioavailability and antitumor activity.

Honokiol (HK) has a variety of biological activities, but its poor solubility limits its application. Rebaudioside A (RA) is able to self-assemble into micelles, which can be used for oral delivery of anticancer drugs. This study aims to create and evaluate a nano-sized anticancer drug delivery system based on RA, as RA micelles are thought to strengthen the therapeutic effects of HK.

Stable Tensor Principal Component Pursuit: Error Bounds and Efficient Algorithms.

The rapid development of sensor technology gives rise to the emergence of huge amounts of tensor (i.e., multi-dimensional array) data.

Partial characterization, in vitro antioxidant and antiproliferative activities of patatin purified from potato fruit juice.

Patatin from potato fruit juice was purified by a combination of ultrafiltration and chromatographic techniques. The in vitro antioxidant and antiproliferative activity against mouse melanoma B16 cells of patatin were investigated. The results showed that the monosaccharide composition of patatin included rhamnose, mannose, glucose, and galactose with a molar ratio of 41 : 30 : 21 : 8, and patatin consisted of (1 → 3) linked α-mannose, (1 → 4) linked α-galactose, (1 → 4) linked β-glucose, and (1 → 2) linked α-rhamnose.