infection may increase the degrees of malignancy in lung adenocarcinoma.

Background: The early diagnosis and management of lung adenocarcinoma co-existing with tuberculosis (LAC-TB) presents significant challenges in clinical settings. This is compounded by a paucity of robust clinical evidence elucidating the interactions between these two conditions.

Methods: This study included 14 patients diagnosed with LAC-TB, with an equal distribution among those with pulmonary tuberculosis (TB) and those with peripheral lymph node TB.

The HTIRDB: A resource containing a transcriptional atlas for 105 different tissues from each of seven species of domestic herbivore.

Here, we describe the Herbivore Transcriptome Integrated Resource Database (HTIRDB, https://yanglab.hzau.edu.

Neoadjuvant pyrotinib and trastuzumab in HER2-positive breast cancer with no early response (NeoPaTHer): efficacy, safety and biomarker analysis of a prospective, multicentre, response-adapted study.

The potential benefits of pyrotinib for patients with trastuzumab-insensitive, HER2-positive early-stage breast cancer remain unclear. This prospective, multicentre, response-adapted study evaluated the efficacy and safety of adding pyrotinib to the neoadjuvant treatment of HER2-positive breast cancer patients with a poor response to initial docetaxel plus carboplatin and trastuzumab (TCbH). Early response was assessed using magnetic resonance imaging (MRI) after two cycles of treatment.

CRISPR/Cas12a with Universal crRNA for Indiscriminate Virus Detection.

Viruses, known for causing widespread biological harm and even extinction, pose significant challenges to public health. Virus detection is crucial for accurate disease diagnosis and preventing the spread of infections. Recently, the outstanding analytical performance of CRISPR/Cas biosensors has shown great potential and they have been considered as augmenting methods for reverse-transcription polymerase chain reaction (RT-PCR), which was the gold standard for nucleic acid detection.

Siamese comparative transformer-based network for unsupervised landmark detection.

Landmark detection is a common task that benefits downstream computer vision tasks. Current landmark detection algorithms often train a sophisticated image pose encoder by reconstructing the source image to identify landmarks. Although a well-trained encoder can effectively capture landmark information through image reconstruction, it overlooks the semantic relationships between landmarks.

Evaluation of CBCT reconstructed tooth models at different thresholds and voxels and their accuracy in fusion with IOS data: an in vitro validation study.

Background: This study aims to evaluate the impact of different thresholds and voxel sizes on the accuracy of Cone-beam computed tomography (CBCT) tooth reconstruction and to assess the accuracy of fused CBCT and intraoral scanning (IOS) tooth models using curvature continuity algorithms under varying thresholds and voxel conditions.

Methods: Thirty-two isolated teeth were digitized using IOS and CBCT at two voxel sizes and five threshold settings. Crown-root fusion was performed using a curvature continuity algorithm.

Core Payload of the Space Gravitational Wave Observatory: Inertial Sensor and Its Critical Technologies.

Since Einstein's prediction regarding the existence of gravitational waves was directly verified by the ground-based detector Advanced LIGO, research on gravitational wave detection has garnered increasing attention. To overcome limitations imposed by ground vibrations and interference at arm's length, a space-based gravitational wave detection initiative was proposed, which focuses on analyzing a large number of waves within the frequency range below 1 Hz. Due to the weak signal intensity, the TMs must move along their geodesic orbit with a residual acceleration less than 10 m/s/Hz.

Prevention of Food Waste in China: Role and Impact of China's Anti-Food Waste Law.

In recent years, despite global improvements in development, food scarcity and waste remain critical issues impacting food security, human health, and environmental sustainability. China's Ministry of Agriculture and Rural Affairs reports that China's food loss and waste rate is approximately 22.7%, amounting to 460 million tons annually, with the consumption and post-harvest processing stages facing the highest losses.

Understanding the effects of different transcranial magnetic stimulation control protocols: a behavioral and neural perspective.

Transcranial magnetic stimulation (TMS) is a noninvasive stimulation technique for modulating brain activity. However, selecting optimal control protocols to account for their neural and non-neural effects remains a challenge. To this end, the present event-related potential (ERP) study investigated the behavioral and neural effects of three commonly used control protocols, namely, sham stimulation and real stimulation with continuous theta burst stimulation (c-TBS) over the vertex and primary visual cortex (V1), on a given task manipulating pitch in voice auditory feedback.

Incremental Classification for High-Dimensional EEG Manifold Representation Using Bidirectional Dimensionality Reduction and Prototype Learning.

In brain-computer interface (BCI) systems, symmetric positive definite (SPD) manifold within Riemannian space has been frequently utilized to extract spatial features from electroencephalogram (EEG) signals. However, the intrinsic high dimensionality of SPD matrices introduces too much computational burden to hinder the real-time applications of such BCI, especially in handling dynamic tasks, like incremental learning. Directly reducing the dimensionality of SPD matrices with conventional dimensionality reduction (DR) methods will alter the fundamental properties of SPD matrices.

AMIR: a multi-omics data platform for Asteraceae plants genetics and breeding research.

As the largest family of dicotyledon, the Asteraceae family comprises a variety of economically important crops, ornamental plants and numerous medicinal herbs. Advancements in genomics and transcriptomic have revolutionized research in Asteraceae species, generating extensive omics data that necessitate an efficient platform for data integration and analysis. However, existing databases face challenges in mining genes with specific functions and supporting cross-species studies.

Alternative Splicing Landscape of Head and Neck Squamous Cell Carcinoma.

Head and neck malignancies are a significant global health concern, with head and neck squamous cell carcinoma (HNSCC) being the sixth most common cancer worldwide accounting for > 90% of cases. In recent years, there has been growing recognition of the potential role of alternative splicing (AS) in the etiology of cancer. Increasing evidence suggests that AS is associated with various aspects of cancer progression, including tumor occurrence, invasion, metastasis, and drug resistance.

PRMT1 promotes Warburg effect by regulating the PKM2/PKM1 ratio in non-small cell lung cancer.

Abnormal epigenetic modifications are involved in the regulation of Warburg effect in tumor cells. Protein arginine methyltransferases (PRMTs) mediate arginine methylation and have critical functions in cellular responses. PRMTs are deregulated in a variety of cancers, but their precise roles in Warburg effect in cancer is largely unknown.

PCMD: A multilevel comparison database of intra- and cross-species metabolic profiling in 530 plant species.

Comparative metabolomics plays a crucial role in investigating gene function, exploring metabolite evolution, and accelerating crop genetic improvement. However, a systematic platform for intra- and cross-species comparison of metabolites is currently lacking. Here, we report the Plant Comparative Metabolome Database (PCMD; http://yanglab.

Classification and characterization of facial asymmetry in adult patients with skeletal Class III malocclusion using cluster analysis.

Introduction: This study aimed to analyze the comprehensive maxillofacial features of patients with skeletal Class III malocclusion and facial asymmetry to develop a classification system for diagnosis and surgical planning.

Methods: A total of 161 adult patients were included, with 121 patients in the asymmetry group (menton deviation >2 mm) and 40 patients in the symmetry group (menton deviation ≤2 mm). Twenty-eight variables were determined, including transverse translation, roll and yaw of each facial unit, transverse width, mandibular morphology, and transverse dental compensation.

De novo transcriptome assembly database for 100 tissues from each of seven species of domestic herbivore.

Domesticated herbivores are an important agricultural resource that play a critical role in global food security, particularly as they can adapt to varied environments, including marginal lands. An understanding of the molecular basis of their biology would contribute to better management and sustainable production. Thus, we conducted transcriptome sequencing of 100 to 105 tissues from two females of each of seven species of herbivore (cattle, sheep, goats, sika deer, horses, donkeys, and rabbits) including two breeds of sheep.

IL-10 and TGF-β1 may weaken the efficacy of preoperative anti-tuberculosis therapy in older patients with spinal tuberculosis.

Spinal tuberculosis is a common extrapulmonary type that is often secondary to pulmonary or systemic infections. infection often leads to the balance of immune control and bacterial persistence. In this study, 64 patients were enrolled and the clinicopathological and immunological characteristics of different age groups were analyzed.

Construction of aptamer-siRNA chimera and glutamine modified carboxymethyl-β-cyclodextrin nanoparticles for the combination therapy against lung squamous cell carcinoma.

Combination therapy has become the most important treatment for advanced non-small cell lung cancer (NSCLC), which can significantly improve the prognosis of patients. However, poor targeting and adverse reactions limited its clinical application. Here, we constructed an AS1411 aptamer-programmed cell death ligand-1 (PD-L1) siRNA chimera/polyethylenimine/glutamine/β-cyclodextrin/doxorubicin (Chimera/ PEI/Gln/β-CD/DOX) nanoparticle for the combination therapy (chemotherapy combined with immunotherapy).

Genetically predicted circulating levels of cytokines and the risk of oral cavity and pharyngeal cancer: a bidirectional mendelian-randomization study.

Epidemiological research has established associations between various inflammatory cytokines and the occurrence of oral cancer and oropharyngeal cancer (OCPC). We performed a Mendelian randomization (MR) analysis to systematically investigate the causal relationship between inflammatory cytokines and OCPC. We performed a bidirectional two-sample MR analysis using OCPC from 12 studies (6,034 cases and 6,585 controls) and genome-wide association study (GWAS) results for 41 serum cytokines from 8,293 Finns, respectively.

Dickkopf-related protein 1 as a biomarker of local immune status and worse prognosis of Oral squamous cell carcinoma.

Background: Oral squamous cell carcinoma (OSCC) is an infiltrative malignancy characterized by a significantly elevated recurrence rate. Dickkopf-related protein 1 (DKK1), which plays an oncogene role in many cancers, acts as an inhibitor of the Wingless protein (Wnt) signaling pathway. Currently, there is a lack of consensus regarding the role of DKK1 in OSCC or its clinical significance.