Integrative bioinformatics analysis of miRNA and mRNA expression profiles and identification of associated miRNA-mRNA network in intracranial aneurysms.

Background: Intracranial aneurysms (IAs) represent protrusions in the vascular wall, with their growth and wall thinning influenced by various factors. These processes can culminate in the rupture of the aneurysm, leading to subarachnoid hemorrhage (SAH). Unfortunately, over half of the patients prove unable to withstand SAH, succumbing to adverse outcomes despite intensive therapeutic interventions, even in premier medical facilities.

Risk Factors for Cerebral Hyperperfusion Syndrome After Combined Revascularization in Adult Patients with Moyamoya Disease.

Background: Cerebral hyperperfusion syndrome (CHS) is known as a complication after bypass surgery for Moyamoya disease (MMD). However, the incidence of CHS has not been accurately reported, and there is no consensus on the risk factors associated with it.

Aim: The aim of this study was to determine the risk factors associated with postoperative CHS after surgical combined revascularization used to treat adult patients with MMD.

Outcomes after superficial temporal artery-middle cerebral artery anastomosis combined with multiple burr hole surgery and dural inversion synangiosis for moyamoya disease in adults.

Objective: Several forms of cerebral revascularization have been carried out to treat moyamoya disease, however, the existing methods are accompanied by a variety of complications. In this study, the authors aimed to evaluate the clinical and angiographic outcomes of a new surgical procedure: superficial temporal artery-middle cerebral artery (STA-MCA) anastomosis combined with multiple burr hole (MBH) surgery and dural inversion synangiosis for the treatment of moyamoya disease in adults.

Methods: Patients treated for moyamoya disease from August 2019 to July 2021 were retrospectively reviewed.

Flows and connections of metabolic nodes in Beijing-Tianjin-Hebei Region and its cities: A study at two scales.

The metabolic processes of cities and their embedded regions have received great attention, but it is still unclear how the metabolic processes change at the scale from cities to urban agglomerations. In view of the lack of multi-scale research in the field of urban metabolism, this study took Beijing-Tianjin-Hebei region, one of the urban agglomerations with largest economic scales in China, as a case to construct metabolic network models at two scales of city and urban agglomeration. The material transfers between nodes were calculated, and the connection degree index was put forward in the ecological network analysis to quantify the influence of a single node on the network when multi-level transfers were considered.

Ultrastable Zinc Anode by Simultaneously Manipulating Solvation Sheath and Inducing Oriented Deposition with PEG Stability Promoter.

Aqueous zinc-ion batteries are a low-cost and safe energy storage system, but suffer from detrimental side reactions and Zn dendrites due to the strong interactions between Zn and water molecules in the electrolytes, and random Zn deposition on the anode surface. Here, an electrolyte involving a dual-functional additive of polyethylene glycol (PEG) to bypass these issues is reported. The electrolyte can not only tailor the solvation sheath of Zn but also enable favorably oriented deposition of Zn on the anode surface.

A Polymer/Graphene Composite Cathode with Active Carbonyls and Secondary Amine Moieties for High-Performance Aqueous Zn-Organic Batteries Involving Dual-Ion Mechanism.

Aqueous zinc-ion batteries (AZIBs) are regarded as one of the most promising alternative technology to lithium-ion batteries on account of their low flammability and cost-benefits. Among various cathode materials in AZIBs, environment-friendly and sustainable organic electrode materials stand out owing to their structural diversity and tunability. However, their limited rate capability and cycle stability remain the obstacles to their further application in AZIBs.

Electrochemical Injection Oxygen Vacancies in Layered CaMnO for Boosting Zinc-Ion Storage.

Manganese-based compounds have emerged as attractive cathode materials for zinc-ion batteries owing to their high operating voltage, large specific capacity, and no pollution. However, the structural collapse and sluggish kinetics of manganese-based compounds are major obstacles that hinder their practical applications. Here, a kind of novel layered CaMnO with a low ion diffusion barrier and high structural stability has been achieved through an electrochemical charging process with in situ injecting oxygen vacancies.

Superior-Performance Aqueous Zinc-Ion Batteries Based on the Growth of MnO Nanosheets on VCT MXene.

Mn-based aqueous zinc-ion batteries (ZIBs) are promising candidate for large-scale rechargeable energy storage because of easy fabrication, low cost, and high safety. Nevertheless, the commercial application of Mn-based cathode is hindered by the challenging issues of low rate capability and poor cyclability. Herein, a manganese-vanadium hybrid, K-VC@MnO cathode, featured with MnO nanosheets uniformly formed on a VCT MXene surface, is elaborately designed and synthesized by metal-cation intercalation and following growth strategy.

LINC00662 sponges miR-107 accelerating the invasiveness and proliferation of glioma cells.

Increasing evidence revealed that the aberrant expression of long non-coding RNAs (lncRNAs) has been implicated in tumorigenesis. However, the role and mechanisms of LINC00662 in glioma have not been elucidated. Here, we show that upregulation of LINC00662 expression in glioma is associated with advanced clinical features and poor prognosis.

Growth Differentiation Factor 5 Improves Neurogenesis and Functional Recovery in Adult Mouse Hippocampus Following Traumatic Brain Injury.

The aim of this study was to investigate the therapeutic effect of growth differentiation factor 5 (GDF-5) on traumatic brain injury (TBI) in mice. We utilized a controlled cortical impact to establish a mouse TBI model, and then stereotaxically administered 25 or 100 ng GDF-5 into the bilateral hippocampal dentate gyrus (DG) of each of the animals. Seven days after the injury, some of the animals were sacrificed for immunohistochemical and immunofluorescence examination of 5-bromo-2'-deoxyuridine (BrdU), Sox-2, doublecortin (DCX) and phosphorylated cAMP response element binding protein (p-CREB).

The 37-kDa laminin receptor precursor regulates the malignancy of human glioma cells.

Glioma is one of the most common brain tumors and one of the most aggressive cancers. Although extensive progress has been made regarding to the diagnosis and treatment, the mortality in glioma patients is still high. Therefore, finding new therapeutic targets to the glioma is critical to the advancement in cancer treatment.

Metabolic coupling of two small-molecule thiols programs the biosynthesis of lincomycin A.

Low-molecular-mass thiols in organisms are well known for their redox-relevant role in protection against various endogenous and exogenous stresses. In eukaryotes and Gram-negative bacteria, the primary thiol is glutathione (GSH), a cysteinyl-containing tripeptide. In contrast, mycothiol (MSH), a cysteinyl pseudo-disaccharide, is dominant in Gram-positive actinobacteria, including antibiotic-producing actinomycetes and pathogenic mycobacteria.

Polyhydroxy cyclohexanols from a Dendrodochium sp. fungus associated with the sea cucumber Holothuria nobilis Selenka.

Four cyclohexanol analogues, dendrodochols A-D (1-4), were isolated from a Dendrodochium sp. fungus associated with the sea cucumber Holothuria nobilis Selenka collected from the South China Sea. The structures were elucidated by means of detailed spectroscopic analysis.

Structure, absolute configuration, and conformational study of 12-membered macrolides from the fungus Dendrodochium sp. associated with the sea cucumber Holothuria nobilis Selenka.

Dendrodolides A-M (1-13), 13 new 12-membered macrolides, were isolated from Dendrodochium sp., a fungus associated with the sea cucumber Holothuria nobilis Selenka, which was collected from the South China Sea. The structures of the dendrodolides were elucidated by means of detailed spectroscopic analysis and X-ray single-crystal diffraction.

Inhibition of heat shock protein response enhances PS-341-mediated glioma cell death.

Background: Previous study indicated that PS-341 induces cell death via JNK pathway in vitro in glioma. However, suppressing proteasome complex by PS-341 may induce expression of heat shock proteins (HSPs), which confer potential protection against cellular stress. In this study, we explored whether induction of HSPs could impair PS-341-induced cell death and whether inhibition of HSPs could enhance cell damage induced by PS-341 in glioma cells.