Publications by authors named "Dongxiao Song"
Article Synopsis
- Chronic pancreatitis (CP) is a serious condition marked by long-term inflammation of the pancreas, leading to issues with digestion and changes in gut bacteria.
- Research indicates a link between changes in gut bacteria (dysbiosis) and the development of CP, but it’s still unclear if dysbiosis actually causes the condition.
- In experiments with mice, using broad-spectrum antibiotics worsened CP symptoms and showed the importance of specific gut bacteria that produce short-chain fatty acids (SCFAs) in managing the disease, suggesting that dietary SCFAs or promoting these beneficial bacteria could offer new ways to treat CP.
Article Synopsis
- Acute pancreatitis (AP) is a complex inflammatory condition of the pancreas, currently lacking specific drug treatments.
- In a study, (R)-TML104, a synthetic analog of resveratrol, was found to significantly reduce symptoms of AP in mice induced by caerulein hyperstimulation, including lower pancreatic edema and serum enzyme levels.
- The mechanism of (R)-TML104's effect involves activating AMP-activated protein kinase and increasing the expression of sirtuin 1 (SIRT1), which in turn reduces inflammation by inhibiting the interleukin 6-STAT3 pathway and decreasing inflammatory cell infiltration in the pancreas.
Apios americana Medik flowers polysaccharide (AFP-2) attenuates HO induced neurotoxicity in PC12 cells.
Int J Biol Macromol
February 2019
Oxidative stress is a critical cause for the progression of neurodegenerative diseases, indicating that screening natural antioxidant and pharmacological targeting of mechanism need more attention. Natural plant polysaccharides are the primary group of natural antioxidants showing mighty antioxidant activity. Therefore, a polysaccharide (AFP-2) from flowers of Apios americana Medik was isolated, purified and characterized.
View Article and Find Full Text PDFTransplantation of bone-marrow-derived mesenchymal stem cells into a murine model of immune thrombocytopenia.
Blood Coagul Fibrinolysis
December 2017
: Several reports have demonstrated T regulatory cells may play an important role in the pathophysiology of immune thrombocytopenia (ITP). As the immunomodulator, bone-marrow-derived mesenchymal stem cells (MSCs) (BM-MSCs) regulate T regulatory cells and show therapeutic effects on autoimmune diseases. However, it is not clear how BM-MSCs affect ITP.
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