Efficacy and Molecular Mechanisms of Nystatin Against on Postharvest Table Grape.

The primary cause of postharvest loss in table grape fruit is attributed to gray mold, which is caused by . The present study confirmed the inhibitory effects of nystatin on the growth and development of , which led to a remarkable reduction in the severity of gray mold on table grape fruits. Furthermore, the application of nystatin disrupted the membrane permeability of , causing increased cellular leakage and cell death.

Anti-hair loss effect of a shampoo containing caffeine and adenosine.

Background: Hair loss is a widespread health problem that affects numerous individuals and is associated with age, lack of sleep, stress, endocrine problems, and other problems. Caffeine exerts various pharmacological effects, particularly after ingestion. The caffeine-induced inhibition of phosphodiesterases can increase intracellular cAMP concentrations, ultimately resulting in stimulatory effects on cell metabolism and proliferation.

The impacts of sodium lauroyl sarcosinate in facial cleanser on facial skin microbiome and lipidome.

Background: The human skin microbiome and lipidome are essential for skin homeostasis and barrier function, and have become a focus in both dermatological and cosmetic fields. However, the influence of surfactants commonly used in cosmetic products on the skin resident microbiome and lipidome remains poorly characterized.

Methods: We conducted self-control experiments to systematically study the effects of surfactant (sodium lauroyl sarcosinate [SLS]) on facial skin.

An optimal Fe-C coordination ensemble for hydrocarbon chain growth: a full Fischer-Tropsch synthesis mechanism from machine learning.

Fischer-Tropsch synthesis (FTS, CO + H → long-chain hydrocarbons) because of its great significance in industry has attracted huge attention since its discovery. For Fe-based catalysts, after decades of efforts, even the product distribution remains poorly understood due to the lack of information on the active site and the chain growth mechanism. Herein powered by a newly developed machine-learning-based transition state (ML-TS) exploration method to treat properly reaction-induced surface reconstruction, we are able to resolve where and how long-chain hydrocarbons grow on complex formed Fe-carbide (FeC) surfaces from thousands of pathway candidates.

Clinical evidence of the efficacy and safety of a new multi-peptide anti-aging topical eye serum.

Background: Skin aging is a complex multifactorial progressive process. With age, intrinsic and extrinsic factors cause the loss of skin elasticity, with the formation of wrinkles, resulting in skin sagging through various pathways. A combination of multiple bioactive peptides could be used as a treatment for skin wrinkles and sagging.

The Regulatory Mechanisms and Control Technologies of Chilling Injury and Fungal Diseases of Postharvest Loquat Fruit.

Loquat is a popular fruit widely cultivated all over the world. It is rich in minerals and carotenoids and has high commercial value. At room temperature, loquat fruit is impressionable to water and nutritional losses, physical damage, and microbial decay, resulting in a short postharvest life.

Alleviates Intestinal Damage Induced by TiO Nanoparticles in Mice on a High-Fat Diet.

Titanium dioxide nanoparticles (TiO NPs) are generally added in considerable amounts to food as a food additive. Oral exposure to TiO NPs could induce intestinal damage, especially in obese individuals with a high-fat diet. The probiotic () exhibits good resistance in the gastrointestinal system and is beneficial to intestinal health.

Automated search for optimal surface phases (ASOPs) in grand canonical ensemble powered by machine learning.

The surface of a material often undergoes dramatic structure evolution under a chemical environment, which, in turn, helps determine the different properties of the material. Here, we develop a general-purpose method for the automated search of optimal surface phases (ASOPs) in the grand canonical ensemble, which is facilitated by the stochastic surface walking (SSW) global optimization based on global neural network (G-NN) potential. The ASOP simulation starts by enumerating a series of composition grids, then utilizes SSW-NN to explore the configuration and composition spaces of surface phases, and relies on the Monte Carlo scheme to focus on energetically favorable compositions.

Compassionate Conservation and the Challenge of Sustainable Wildlife Management: A Survey of the Urban Public of China.

Sustainable wildlife management (SWM) is based on a synergy of traditional/local knowledge, advances in scientific knowledge, and fast-evolving economic and social circumstances. A widely accepted cornerstone of SWM globally is that conservation and utilization need to be effectively integrated, emphasizing the benefits humans can derive from biodiversity, thereby further encouraging people to protect and value wildlife though its management. However, with demand from biological resources growing at an unprecedented rate and the emergence of social media, conservationists must respond quickly to new challenges and conflicts associated with species management and public policy.

Current Societal Views about Sustainable Wildlife Management and Conservation: A Survey of College Students in China.

Wildlife conservation and management has become a very complex public policy issue in China as concerns over on animal welfare and empathy for animals have grown. Science-based conservation strategies that are oriented toward sustainable wildlife management (SWM) are under threat as these new attitudes and values emerge and take hold. This study accesses the attitudes of college students towards SWM and wildlife conservation, and investigates demographic characteristics influencing their attitudes in China, a country that is traditionally associated with consumptive use of wildlife and SWM, but where new ideas about wildlife conservation are emerging.

Boosting Catalysis of Pd Nanoparticles in MOFs by Pore Wall Engineering: The Roles of Electron Transfer and Adsorption Energy.

The chemical environment of metal nanoparticles (NPs) possesses significant influence on their catalytic performance yet is far from being well understood. Herein, tiny Pd NPs are encapsulated into the pore space of metal-organic frameworks (MOFs), UiO-66-X (X = H, OMe, NH , 2OH, 2OH(Hf)), affording Pd@UiO-66-X composites. The surface microenvironment of the Pd NPs is readily modulated by pore wall engineering, via the functional group and metal substitution in the MOFs.

Rational magnetic modification of N,N-dioxidized pyrazine ring expanded adenine and thymine: a diradical character induced by base pairing and double protonation.

Rational modification of biomolecules especially DNA base pairs for the theoretical design of molecular magnets has attracted extensive interest. In this work, we report a modification strategy for adenine/thymine-based magnets through introducing a N,N-dioxidized pyrazine ring to either adenine or thymine to form ring-expanded bases (noA/noT) based on their experimentally synthesized derivatives. Further functionalization is conducted by double protonation and pairing with a normal complementary base (nohA-T/nohT-A), respectively.

[Clinical trials of acupuncture treatment of post-stroke dysphagia by deep acupuncture of Tiantu (CV22) in combination with swallowing rehabilitation training].

Objective: To observe the effect of deep acupuncture of Tiantu (CV22), etc. in combination with rehabilitation training on swallowing function of patients with post-stroke dysphasia.

Methods: A total of 70 patients suffering from post-stroke dysphagia were randomly divided into control group (conventional acupuncture＋ swallowing rehabilitation training) and treatment group (deep acupuncture of CV22 ＋ rehabilitation training, ＝ 35 cases in each group).

Formulation, Pharmacokinetic Evaluation and Cytotoxicity of an Enhanced- penetration Paclitaxel Nanosuspension.

Background: Improving poorly soluble drugs into druggability was a major problem faced by pharmaceutists. Nanosuspension can improve the druggability of insoluble drugs by improving the solubility, chemical stability and reducing the use of additives, which provided a new approach for the development and application of the insoluble drugs formulation. Paclitaxel (PTX) is a well-known BCS class IV drug with poor solubility and permeability.

Formulation and characterization of biocompatible and stable I.V. itraconazole nanosuspensions stabilized by a new stabilizer polyethylene glycol-poly(β-Benzyl-l-aspartate) (PEG-PBLA).

Amphiphilic block copolymers, PEG-PBLA with different molecular weights, were synthesized and used as new stabilizers for Itraconazole nannosuspensions (ITZ-PBLA-Nanos). ITZ-PBLA-Nanos were prepared by the microprecipitation-high pressure homogenization method, and the particle size and zeta potential were measured using a ZetaSizer Nano-ZS90. Morphology and crystallinity were studied using TEM, DSC and powder X-ray.

Chemical Sensors Based on Metal-Organic Frameworks.

Metal-organic frameworks (MOFs) as chemical sensors have developed rapidly in recent years. There have been many papers concerning this field and interest is still growing. The reason is that the specific merits of MOFs can be utilized to enhance sensitivity and selectivity by various energy/charge transfers occurring among different ligands, ligand, and metal centers, such as from ligands to metal centers or metal centers to ligands, as well as from MOF skeletons to guest species.

The Neurochemical and Microstructural Changes in the Brain of Systemic Lupus Erythematosus Patients: A Multimodal MRI Study.

The diagnosis and pathology of neuropsychiatric systemic lupus erythematosus (NPSLE) remains challenging. Herein, we used multimodal imaging to assess anatomical and functional changes in brains of SLE patients instead of a single MRI approach generally used in previous studies. Twenty-two NPSLE patients, 21 non-NPSLE patients and 20 healthy controls (HCs) underwent 3.

Brain responses to acupuncture are probably dependent on the brain functional status.

In recent years, neuroimaging studies of acupuncture have explored extensive aspects of brain responses to acupuncture in finding its underlying mechanisms. Most of these studies have been performed on healthy adults. Only a few studies have been performed on patients with diseases.

Low-potential detection of endogenous and physiological uric acid at uricase-thionine-single-walled carbon nanotube modified electrodes.

This work develops and validates an electrochemical approach for uric acid (UA) determinations in both endogenous (cell lysate) and physiological (serum) samples. This approach is based on the electrocatalytic reduction of enzymatically generated H(2)O(2) at the biosensor of uricase-thionine-single-walled carbon nanotube/glassy carbon (UOx-Th-SWNTs/GC) with the use of Th-SWNTs nanostructure as a mediator and an enzyme immobilization matrix. The biosensor, which was fabricated by immobilizing UOx on the surface of Th-SWNTs, exhibited a rapid response (ca.