Impacts of planting structure adjustment on water saving in the Shiyang River Basin of Arid Region.

Planting structure adjustment (PSA) affects agricultural water saving, and is an essential part of water-saving agricultural construction. This study introduced virtual water theory and innovatively constructed a model to assess the water-saving effects of PSA in Shiyang River Basin over the past 38 years, explore the relationship between planting structure and water saving, and clarify the most water-saving planting structure. The results showed that the sown area of economic crops consistently increased as food crop areas decreased in the four counties (districts) from 1980 to 2017.

Screening for Fabry disease in patients with left ventricular hypertrophy in China: A multicentre and prospective study.

Aims: Left ventricular hypertrophy (LVH) is frequently detected via echocardiography in individuals with Fabry disease (FD), sometimes leading to confusion with hypertrophic cardiomyopathy (HCM) of other aetiologies. Considering this diagnosis challenge, FD should be included in the list of differential diagnosis for patients presenting with LVH. To address this concern, we conducted a prospective screening study in China, using dried blood spot (DBS) testing, to evaluate patients with unexplained LVH.

Knowledge, attitudes, and practice of physicians and pharmacists regarding the prevention and treatment of cardiovascular toxicity associated with cancer treatment.

This study aimed to explore physicians' and pharmacists' knowledge, attitudes, and practice (KAP) regarding the prevention and treatment of cardiovascular toxicity associated with cancer treatment. A multicenter cross-sectional study included physicians and pharmacists between April 2023 and June 2023. The study included 918 participants (514 physicians and 404 pharmacists).

Effects of Konjac Glucomannan and Its Oligosaccharides on Improvement of Lactose Intolerance as Gut Prebiotics.

Lactose intolerance (LI) is a widespread health issue affecting almost 70% of the world population. This study evaluates the potential prebiotic benefits of konjac glucomannan (KGM) and konjac oligogalactomannan (KOGM) in improving LI. Colonic fermentation results indicate that lactase groups of healthy subjects showed lower pH, higher lactic acid content, and lactase activity in fermentation broth compared with LI subjects.

Model prediction of radioactivity levels in the environment and food around the world's first AP 1000 nuclear power unit.

Objectives: Model prediction of radioactivity levels around nuclear facilities is a useful tool for assessing human health risks and environmental impacts. We aim to develop a model for forecasting radioactivity levels in the environment and food around the world's first AP 1000 nuclear power unit.

Methods: In this work, we report a pilot study using time-series radioactivity monitoring data to establish Autoregressive Integrated Moving Average (ARIMA) models for predicting radioactivity levels.

The regulation of chromatin configuration at AGAMOUS locus by LFR-SYD-containing complex is critical for reproductive organ development in Arabidopsis.

Switch defective/sucrose non-fermentable (SWI/SNF) chromatin remodeling complexes are evolutionarily conserved, multi-subunit machinery that play vital roles in the regulation of gene expression by controlling nucleosome positioning and occupancy. However, little is known about the subunit composition of SPLAYED (SYD)-containing SWI/SNF complexes in plants. Here, we show that the Arabidopsis thaliana Leaf and Flower Related (LFR) is a subunit of SYD-containing SWI/SNF complexes.

Mitophagy associated self-degradation of phosphorylated MAP4 guarantees the migration and proliferation responses of keratinocytes to hypoxia.

Our previous study has announced that phosphorylated microtubule-associated protein 4 (p-MAP4) accelerated keratinocytes migration and proliferation under hypoxia through depolymerizing microtubules. However, p-MAP4 should exhibit inhibitory effects on wound healing, for it also impaired mitochondria. Thus, figuring out the outcome of p-MAP4 after it impaired mitochondria and how the outcome influenced wound healing were far-reaching significance.

Dealloying Synthesis of Bimetallic (Au-Pd)/CeO Catalysts for CO Oxidation.

The nanorod-structured (Au-Pd)/CeO catalysts with different Au/Pd ratios were prepared from Al-Ce-Au-Pd precursor alloys through combined dealloying and calcination treatment. XRD, SEM, TEM, XPS, Raman spectroscopy, and N adsorption-desorption measurements were applied to test the structure and physicochemical properties of samples. Catalytic evaluation results imply that the (Pd-Au)/CeO catalyst calcined at 500 °C possesses optimal catalytic activity for CO oxidation when compared with other catalysts with different Au/Pd ratios or (Pd-Au)/CeO calcined at other temperatures, whose 50% and 99% reaction temperature can be reached as low as 50 and 85 °C, respectively.

Optimizing heterotrophic nitrification process: The significance of demand-driven aeration and organic matter concentration.

Heterotrophic nitrification and aerobic denitrification (HNAD) sludge were successfully acclimated. The effects of organics and dissolved oxygen (DO) on nitrogen and phosphorus removal by the HNAD sludge were investigated. The nitrogen can be heterotrophically nitrified and denitrified in the sludge at a DO of 6 mg/L.

Atrial fibrillation classification based on the 2D representation of minimal subset ECG and a non-deep neural network.

Atrial fibrillation (AF) is the most common cardiac arrhythmia, and its early detection is critical for preventing complications and optimizing treatment. In this study, a novel AF prediction method is proposed, which is based on investigating a subset of the 12-lead ECG data using a recurrent plot and ParNet-adv model. The minimal subset of ECG leads (II &V1) is determined a forward stepwise selection procedure, and the selected 1D ECG data is transformed into 2D recurrence plot (RP) images as an input to train a shallow ParNet-adv Network for AF prediction.

Cardiac Arrhythmia classification based on 3D recurrence plot analysis and deep learning.

Artificial intelligence (AI) aided cardiac arrhythmia (CA) classification has been an emerging research topic. Existing AI-based classification methods commonly analyze electrocardiogram (ECG) signals in lower dimensions, using one-dimensional (1D) temporal signals or two-dimensional (2D) images, which, however, may have limited capability in characterizing lead-wise spatiotemporal correlations, which are critical to the classification accuracy. In addition, existing methods mostly assume that the ECG data are linear temporal signals.

Long-term investigation of environmental radioactivity levels and public health around the Qinshan Nuclear Power Plant, China.

To evaluate the impact of the Qinshan Nuclear Power Plant (Qinshan NPP) in normal operation on the surrounding environment and population, the radioactivity levels of drinking water and the ambient environment, as well as the residents' cancer incidence, were continuously monitored for a period of 9 years (2012-2020). All of the gross α and β radioactivity concentrations in drinking water were less than the WHO recommended values (0.5 Bq/L for gross α and 1 Bq/L for gross β).

Impaired Retrograde Transport Due to Lack of TBC1D5 Contributes to the Trafficking Defect of Lysosomal Cathepsins in Ischemic/Hypoxic Cardiomyocytes.

Lysosomal dysfunction has been found in many pathological conditions, and methods to improve lysosomal function have been reported to be protective against infarcted hearts. However, the mechanisms underlying lysosomal dysfunction caused by ischemic injury are far less well-established. The retromer complex is implicated in the trafficking of cation-independent mannose 6-phosphate receptor (CI-MPR), which is an important protein tag for the proper transport of lysosomal contents and therefore is important for the maintenance of lysosomal function.

Therapeutic Effects of Shikonin on Skin Diseases: A Review.

Shikonin is one of the primary active components extracted from the dried root of (), a traditional Chinese herbal medicine. Shikonin is known to not only exert anti-proliferative, anti-inflammatory, and anti-angiogenic activities, but also play a crucial role in triggering the production of reactive oxygen species, suppressing the release of exosomes, and inducing apoptosis. Increasing evidence suggests that shikonin has a protective effect against skin diseases, including psoriasis, melanoma, and hypertrophic scars.

Long-term variation of Sr and Cs in environmental and food samples around Qinshan nuclear power plant, China.

Environmental radioactivity monitoring in the surroundings of nuclear facilities is important to provide baseline data for effective detection in case of any radioactive release in the region. In this work, we report for the first time the long-term monitoring data of Cs and Sr in environmental and food samples around Qinshan nuclear power plant in 2012-2019. The distribution levels, temporal variations and source terms of Cs and Sr in the investigated samples were discussed.

Microtubule associated protein 4 (MAP4) phosphorylation reduces cardiac microvascular density through NLRP3-related pyroptosis.

Phosphorylation of MAP4 (p-MAP4) causes cardiac remodeling, with the cardiac microvascular endothelium being considered a vital mediator of this process. In the current study, we investigated the mechanism underlying p-MAP4 influences on cardiac microvascular density. We firstly confirmed elevated MAP4 phosphorylation in the myocardium of MAP4 knock-in (KI) mice.

Autophagy-Related LC3 Accumulation Interacted Directly With LIR Containing RIPK1 and RIPK3, Stimulating Necroptosis in Hypoxic Cardiomyocytes.

The exact relationships and detailed mechanisms between autophagy and necroptosis remain obscure. Here, we demonstrated the link between accumulated autophagosome and necroptosis by intervening with autophagic flux. We first confirmed that the LC3 interacting region (LIR) domain is present in the protein sequences of RIPK1 and RIPK3.

Clinical significance of hypertension in patients with different types of cancer treated with antiangiogenic drugs.

Hypertension is a common comorbidity in patients receiving antiangiogenic therapy. Prior studies have reported worsening or new-onset hypertension as an adverse event of antiangiogenetic therapy, which can be managed by dose reduction or discontinuation of the culprit medication. By contrast, other studies have found that the occurrence of hypertension is a potential biomarker associated with greater efficacy of antiangiogenic therapy and predicts improved survival.

H(+)/Cl(‑) exchange transporter 7 promotes lysosomal acidification‑mediated autophagy in mouse cardiomyocytes.

Autophagy protects cardiomyocytes in various pathological and physiological conditions; however, the molecular mechanisms underlying its influence and the promotion of autophagic clearance are not completely understood. The present study aimed to explore the role of H(+)/Cl(‑) exchange transporter 7 (CLC‑7) in cardiomyocyte autophagy. In this study, rapamycin was used to induce autophagy in mouse cardiomyocytes, and the changes in CLC‑7 were investigated.

CELSR1 Acts as an Oncogene Regulated by miR-199a-5p in Glioma.

Purpose: This study aimed to elucidate the biological function and upstream regulatory mechanism of CELSR1 in glioma.

Materials And Methods: We evaluated the expression of CELSR1 in glioma by TCGA_GEPIA tool, RT-qPCR, and Western blot assays. CCK-8, wound healing, and transwell invasion assays were, respectively, performed to detect the effect of CELSR1 on cell proliferation, migration, and invasion.

CD38 Causes Autophagic Flux Inhibition and Cardiac Dysfunction Through a Transcriptional Inhibition Pathway Under Hypoxia/Ischemia Conditions.

Induced autophagy is protective against myocardial hypoxia/ischemia (H/I) injury, but evidence regarding the extent of autophagic clearance under H/I and the molecular mechanisms that influence autophagic flux has scarcely been presented. Here, we report that CD38 knockout improved cardiac function and autophagic flux in mice and neonatal cardiomyocytes (CMs) under H/I conditions. Mechanistic studies demonstrated that overexpression of CD38 specifically downregulated the expression of Rab7 and its adaptor protein pleckstrin homology domain-containing protein family member 1 (PLEKHM1) through nicotinamide adenine dinucleotide (NAD)-dependent and non-NAD-dependent pathways, respectively.