Publications by authors named "Dongxia Qin"
Article Synopsis
- Diabetic hyperglycemia disrupts arterial smooth muscle function, causing complications due to enhanced vasoconstriction and altered Ca1.2 calcium channel activity.
- In diabetic rat models, it was found that specific splicing changes in the Ca1.2 channel occur, which increase its function and promote vasoconstriction.
- The study highlights that advanced glycation end-products (AGEs), rather than glucose, regulate these changes by affecting the splicing factor Rbfox1, offering a potential target for treating complications in diabetic patients.
Background: L-type Ca channel Ca1.2 is essential for cardiomyocyte excitation, contraction and gene transcription in the heart, and abnormal functions of cardiac Ca1.2 channels are presented in diabetic cardiomyopathy.
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