Gadolinium-Based Magnetic Resonance Theranostic Agent with Gallic Acid as an Anti-Neuroinflammatory and Antioxidant Agent.

Studies in the field have actively pursued the incorporation of diverse biological functionalities into gadolinium-based contrast agents, aiming at the amalgamation of MRI imaging and therapeutic capabilities. In this research, we present the development of Gd-Ga, an anti-neuroinflammatory MR contrast agent strategically designed to target inflammatory mediators for comprehensive imaging diagnosis and targeted lesion treatment. Gd-Ga is a gadolinium complex composed of 1,4,7-tris(carboxymethylaza)cyclododecane-10-azaacetylamide (DO3A) conjugated with gallic acid (3,4,5-trihydroxybenzoic acid).

The effect of backpack weight on the performance of basic short-term/working memory tasks while walking along a pre-determined route.

This study investigated possible backpack weight effects on the performance of three basic short-term/working memory (STM/WM) tasks conducted concurrently with the physical task of route walking. The STM/WM tasks were the Corsi block-tapping, digit span, and 3-back tasks, and, were employed to examine the visuo-spatial sketchpad, phonological loop and central executive components of the WM system. Four backpack weight levels (0%, 15%, 25% and 40% of body mass) were considered.

Severe obesity effect on low back biomechanical stress of manual load lifting.

Background: Little research is available on low back biomechanical stresses that obese and overweight workers experience from manual load lifting.

Objective: The study objective was to quantitatively evaluate low back biomechanical stresses of severely obese (BMI≥35 kg/m2) workers during manual lifts of moderate load weights.

Method: Twenty severely obese and 20 normal weight participants performed infrequent lifting in 16 task conditions.