Uncertainty quantification of a three-dimensional in-stent restenosis model with surrogate modelling.

In-stent restenosis is a recurrence of coronary artery narrowing due to vascular injury caused by balloon dilation and stent placement. It may lead to the relapse of angina symptoms or to an acute coronary syndrome. An uncertainty quantification of a model for in-stent restenosis with four uncertain parameters (endothelium regeneration time, the threshold strain for smooth muscle cell bond breaking, blood flow velocity and the percentage of fenestration in the internal elastic lamina) is presented.