Chronobiological variations of acute aortic dissection in a Northwest Chinese population.

Background: The prevalence of acute aortic dissection (AAD) has been gradually increasing in recent years. This study aimed to investigate the circadian variations of AAD onset in a northwest Chinese population and provide scientific insights for AAD prevention.

Methods: The clinical data of 1,145 AAD patients admitted to our hospital between January 2010 and December 2020 were retrospectively collected, and the periodic features of AAD were analyzed.

Versatile functionalization of surface-tailorable polymer nanohydrogels for drug delivery systems.

Surface decoration of nanohydrogels with functional molecules as well as nanomaterials offers a facile approach for developing multifunctional drug nanocarriers. Herein, the surface-tailorable polymer nanohydrogels, with the catechol groups as a universal anchor, were prepared by simple reflux-precipitation polymerization for versatile functionalization as drug delivery systems. The resultant polymer nanohydrogels were not only capable of delivering doxorubicin (DOX) through electrostatic interactions, but also exhibited facile conjugation with magnetic Fe3O4 nanoparticles and anticancer drug bortezomib (BTZ) via the versatile catechol-based coupling chemistry.

Double-chambered left ventricle: A rare case in a child.

Double-chambered left ventricle (DCLV) is an extremely rare congenital heart disease. In this condition, the left ventricle is divided into two chambers by a septum or muscle fiber with abnormal proliferation. A symptomatic boy was diagnosed with DCLV at our hospital.

A rare case of biventricular myxoma.

Background: Cardiac myxoma is the most common primary cardiac tumor. Approximately 75-80% of myxomas are located in the left atrium. Occurrence of multiple myxomas is extremely rare.

MicroRNA array analysis of microRNAs related to systemic scleroderma.

MicroRNAs are short, 18- to 25-nt sequences of noncoding, single-stranded RNA that function as regulatory molecules and participate in a series of vital processes including early development, cell proliferation, cell differentiation, apoptosis, substance metabolism and the pathogenesis of human diseases. This study compared the microRNA profiles of patients with systemic scleroderma (SSc) and healthy control individuals to investigate the pathogenesis of SSc. Skin tissue was isolated from three patients with SSc and three healthy controls.

Chemical analysis of Agaricus blazei polysaccharides and effect of the polysaccharides on IL-1beta mRNA expression in skin of burn wound-treated rats.

Agaricus blazei polysaccharides were analyzed by GC-MS. Results indicated that the polysaccharides contained glucose (93.87%), mannose (3.

[Migratory and chemoattractant responses of mesenchymal stem cells to oxidative stress injury of endothelial cell in vitro].

Objective: To investigate the possibilities of human mesenchymal stem cells (hMSCs) migrating toward the oxidative stress injuries of endothelial cells.

Methods: hMSCs were isolated and cultured from human marrow in vitro and the multipotential differentiation of P3 hMSCs identified by specific medium induced to differentiate into osteoblasts, adipocytes and endothelial cells. And the marker antigen of P3 hMSCs was detected by flow cytometry (FCM) and immunohistochemistry.